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Exploring the impact of sustainable value proposition on firm performance
2022
Considering the immense potential of sustainable business models in tackling the broader challenge of corporate sustainability, this paper integrates the literature streams on sustainability practices and organizational business models to analyze the performance implications of a firm's sustainable value proposition. Based on the analysis of a large panel dataset across different industries, consistent with the proposed theory, a sustainable value proposition has been found to have a positive impact on a firm's market-based financial performance (namely, Tobin's Q). Yet, this impact turns out to be highly context-dependent. In particular, the findings reveal that a firm's R&D capabilities i…
Stem cell populations in the heart and the role of Isl1 positive cells
2013
Cardiac progenitor cells are multipotent stem cells isolated from both embryonic and adult hearts in several species and are able to differentiate at least into smooth muscle cells, endothelial cells and cardiomyocytes. The embryonic origin of these cells has not yet been demonstrated, but it has been suggested that these cells may derive from the first and secondary heart fields and from the neural crest. In the last decade, two diffe-rent populations of cardiac progenitor or stem cells have been identified and isolated, i.e., the Islet1 positive (Isl1+) and c-Kit positive (c-Kit+)/Stem Cell Antigen-1 positive (Sca-1+) cells. Until 2012, these two populations have been considered two separ…
An antique lead coffin discovered in Évreux (Eure): a multidisciplinary study
2013
The Roman cemetery of le Clos au Duc in Évreux (Eure) lasted from the 1st to the 4th c. AD. The most common funerary practice in the 1st c. AD was cremation. From the beginning of the 2nd c. AD this rapidly gave place to inhumation burials. By the end of the 3rd c. lead coffins could be found in burials, but it remained a minority practice reserved for an elite. The 2010 excavation in Évreux allowed the recovery of an example of these. It was incomplete, but the good preservation of its remains made a multidisciplinary study possible. Apart from the bones of a young woman, the lead coffin contained coins, textile, fur, calcite (CaCO3) and insects. These results make it possible to retrace t…
Role of RNA Motifs in RNA Interaction with Membrane Lipid Rafts: Implications for Therapeutic Applications of Exosomal RNAs
2021
RNA motifs may promote interactions with exosomes (EXO-motifs) and lipid rafts (RAFT-motifs) that are enriched in exosomal membranes. These interactions can promote selective RNA loading into exosomes. We quantified the affinity between RNA aptamers containing various EXO- and RAFT-motifs and membrane lipid rafts in a liposome model of exosomes by determining the dissociation constants. Analysis of the secondary structure of RNA molecules provided data about the possible location of EXO- and RAFT-motifs within the RNA structure. The affinity of RNAs containing RAFT-motifs (UUGU, UCCC, CUCC, CCCU) and some EXO-motifs (CCCU, UCCU) to rafted liposomes is higher in comparison to aptamers withou…
Binding of RNA Aptamers to Membrane Lipid Rafts: Implications for Exosomal miRNAs Transfer from Cancer to Immune Cells
2020
Intraluminal vesicles (ILVs) are released into the extracellular space as exosomes after the fusion of multivesicular bodies (MVBs) with the plasma membrane. miRNAs are delivered to the raft-like region of MVB by RNA-binding proteins (RBPs). RNA loading into exosomes can be either through direct interaction between RNA and the raft-like region of the MVB membrane, or through interaction between an RBP&ndash
Valodu mācību jomas apguve pirmsskolas izglītības 2. posmā, integrējot literatūru
2022
Diplomdarba temats ir “valodu mācību jomu apguve pirmsskolas izglītības 2. posmā, integrējot literatūru”. Darba mērķis: pētīt valodu mācību jomas apguvi pirmsskolas izglītības 2. posmā, integrējot literatūru. Izmantotās metodes pētījuma veikšanai: literatūras analīze, bērnu novērošana, izmēģinājuma darbība, iegūto rezultātu analīze. Teorētiskā daļa sevī ietver literatūras analīzi par bērnu valodas attīstību, psiholoģiski pedagoģisko raksturojumu, valodu jomas un literatūras apguvi pirmsskolas programmā, kā arī valodas un literatūras integrācijas iespējām. Empīriskajā daļā iekļauti novērojumi un to analīze par bērnu valodas prasmēm pirms un pēc izmēģinājuma darbības, kuras laikā tika izstrād…
The Role of Reputation on Trust and Loyalty : A Cross-Cultural Analysis of Tablet E-Tailing
2018
The purpose of this article is to empirically examine the role of online retailer's website reputation on tablet commerce and to compare the trust arbitration between reputation and loyalty in two cultures - Finland and Nigeria. Data was collected from Finland and Nigeria, using purposive and snowball sampling methods. This article uses Structural Equation Modelling and mediation analysis. The results reveal that the reputation of online retailer's website is not a direct determinant of loyalty for online shopping while trust colligates with ease of use. The effect of an online retailer's website reputation is stronger in Nigeria than in Finland and trust is a strong predictor of ease of us…
Combining Sequence Analysis and Hidden Markov Models in the Analysis of Complex Life Sequence Data
2018
Life course data often consists of multiple parallel sequences, one for each life domain of interest. Multichannel sequence analysis has been used for computing pairwise dissimilarities and finding clusters in this type of multichannel (or multidimensional) sequence data. Describing and visualizing such data is, however, often challenging. We propose an approach for compressing, interpreting, and visualizing the information within multichannel sequences by finding (1) groups of similar trajectories and (2) similar phases within trajectories belonging to the same group. For these tasks we combine multichannel sequence analysis and hidden Markov modelling. We illustrate this approach with an …
Low-rank approximation based non-negative multi-way array decomposition on event-related potentials
2014
Non-negative tensor factorization (NTF) has been successfully applied to analyze event-related potentials (ERPs), and shown superiority in terms of capturing multi-domain features. However, the time-frequency representation of ERPs by higher-order tensors are usually large-scale, which prevents the popularity of most tensor factorization algorithms. To overcome this issue, we introduce a non-negative canonical polyadic decomposition (NCPD) based on low-rank approximation (LRA) and hierarchical alternating least square (HALS) techniques. We applied NCPD (LRAHALS and benchmark HALS) and CPD to extract multi-domain features of a visual ERP. The features and components extracted by LRAHALS NCPD…
El análisis marxista de las necesidades sociales
2018
The disappearance of the so-called «real socialism» has concealed the validity of the Marxist analysis of social reality. One of the sets of hypotheses that has best maintained its heuristic capacity is the Marxist theory of needs. The Marxist hypotheses have been developed in debate with other conventional conceptions. Currently, feminism and the ecological analysis of needs are renewing the views of Heller and Habermas.