Search results for "marker"
showing 10 items of 3799 documents
Liquid biomarkers for fibrotic NASH – progress in a complex field
2022
Inherited Neuromuscular Disorders: Which Role for Serum Biomarkers?
2021
Inherited neuromuscular disorders (INMD) are a heterogeneous group of rare diseases that involve muscles, motor neurons, peripheral nerves or the neuromuscular junction. Several different lab abnormalities have been linked to INMD: sometimes they are typical of the disorder, but they usually appear to be less specific. Sometimes serum biomarkers can point out abnormalities in presymtomatic or otherwise asymptomatic patients (e.g., carriers). More often a biomarker of INMD is evaluated by multiple clinicians other than expert in NMD before the diagnosis, because of the multisystemic involvement in INMD. The authors performed a literature search on biomarkers in inherited neuromuscular disord…
L’apport thérapeutique des approches protéomiques dans les cancers
2011
Up to now, there are no protein tumor markers with a specificity and sensitivity sufficient to have a utility in prognosis and early diagnosis of cancer. Recent advances in proteomics approaches have led to the identification of novel tumor markers of cancer that may have a utility in screening strategies and treatment. The purpose of the current review is to describe the major advances in cancer proteomics, especially those related to the study of serum biomarkers, immune-related responses (autoantibodies) and alterations in cellular proteins.
Ketone body 3-hydroxybutyrate: a biomarker of aggression?
2020
Human aggression is a complex behavior, the biological underpinnings of which remain poorly known. To gain insights into aggression biology, we studied relationships with aggression of 11 low-molecular-weight metabolites (amino acids, ketone bodies), processed using 1H nuclear magnetic resonance spectroscopy. We used a discovery sample of young adults and an independent adult replication sample. We studied 725 young adults from a population-based Finnish twin cohort born 1983-87, with aggression levels rated in adolescence (ages 12, 14, 17) by multiple raters and blood plasma samples at age 22. Linear regression models specified metabolites as the dependent and aggression ratings as indepen…
Cadmium, Copper and Tributyltin effects on fertilization of Paracentrotus lividus (Echinodermata)
2009
Marine environments are continuously being threatened by a large number of xenobi- otics from anthropogenic sources. The effect of chemical pollution on living organisms are numerous and may impair reproductive success of adults species of marine invertebrate and vertebrate through effects on gamete quality. Echinoderms are characterized by external fertilizzation and gametes, free of any type of protection, may be in contact with toxic substances so the reproductive success depends largely on the environment conditions. The purpose of this work is to assess the effects on the in vitro fertiliza- tion of exposure of sea urchin Paracentrotus lividus gametes to xenobiotic substances as CuSO4,…
Using discourse markers to negotiate epistemic stance: A view from situated language use
2021
Abstract In this paper, I analyse the usage of a discourse marker =mari, belonging to the epistemic paradigm attested in Upper Napo Kichwa (Quechuan, Ecuador). I show that the use of =mari indicates that the information is known well to the speaker, but also to some extent familiar to the addressee. In situated language use, the marker contributes to creating a knowing epistemic stance of the speaker. The analysis presented here is based on a 13-h documentary corpus of interactive Upper Napo Kichwa discourse, recorded on audio and video. For the purpose of the paper, the relevant utterances are analysed in their broad interactional context, including not only the surrounding text, but also …
Outlining a grammaticalization path for the Spanish formula en plan (de): A contribution to crosslinguistic pragmatics
2020
Abstract This article discusses the diachronic development of the Spanish multifunctional formula en plan (with its variant en plan de, literally ‘in plan (of)’ but usually equivalent to English like). The article has two main aims: firstly, to describe the changes that the formula has undergone since its earliest occurrences as a marker in the nineteenth century up to the early 21st century. The diachronic study evinces a process of grammaticalization in three steps: from noun to clause adverbial and then to discourse marker. Secondly, to conduct a contrastive analysis between en plan (de) and the English markers like and kind of/kinda so as to shed new light on the potential existence of …
Trajectories of stress biomarkers and anxious-depressive symptoms from pregnancy to postpartum period in women with a trauma history
2019
Background: Cross-sectional studies have found that a trauma history can be associated with anxious-depressive symptomatology and physiological stress dysregulation in pregnant women. Methods: This prospective study examines the trajectories of both anxiety and depressive symptoms and salivary cortisol and alpha-amylase biomarkers from women with (n = 42) and without (n = 59) a trauma history at (i) 38th week of gestation (T1), (ii) 48 hours after birth (T2), and (iii) three months after birth (T3). Results: The quantile regression model showed that trauma history was associated with higher cortisol levels at T1 and this difference was sustained along T2 and T3. Conversely, there were no si…
What genres tell us about evidentials and vice versa
2018
Abstract The aim of this paper is twofold. First, it aims to delve into the influence of contextual discursive factors in determining the type of evidential chosen and the pragmatic functions developed by evidentials in Spanish parliamentary discourse; second, it shows how evidentials can also provide useful new insight on the genre. A corpus study has been carried out studying the Spanish evidential discourse marker al parecer in parliamentary debates. The analysis shows how real examples of al parecer hardly fit any category of evidentials posited previously; data also illustrates how factors such as the discursive role or the part of the parliamentary process do affect the meaning of al …
Clinical utility of biochemical markers for the prediction of COVID-19-related mortality in kidney transplant recipients
2021
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