Search results for "medicinal"

Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 5. Mitt. Imidazo[4,5-h]isochinoline

1975

Es werden zwei Wege zur Darstellung des neuen Heterotricyclus Imidazo[4,5-h]isochinolin (7a) sowie zwei seiner partiell hydrierten Derivate 6, 7, 8, 9-Tetrahydro-imidazo[4,5-h]isochinolin (7b) und 4,5,5a,6,7,8,9,9a-Octahydro-imidazo-[4,5-h]isochinolin (7c) beschrieben. Imidazo[4,5-h]isoquinolines Two ways for the preparation of the new heterotricycle imidazo[4,5-h]isoquinoline (7a) and two of its partially reduced derivatives, 6,7,8,9-tetrahydro-imidazo[4,5-h]isoquinoline (7b) and 4,5,5a,6,7,8,9,9a-octahydro-imidazo[4,5-h]isoquinoline (7c), are described.

Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 7. Mitt. Pyridyl- und Piperidyl-histamine

1975

Es wurden die drei isomeren 2-substituierten Piperidyl-(7) und Pyridyl-histamine (6) aus den entsprechenden 2-substituierten 4-Hydroxymethyl-imidazolen (8) oder 4-(2-Hydroxy-athyl)-imidazolen (3) auf 2 verschiedenen Wegen dargestellt und auf ihre histaminartige Wirksamkeit untersucht. Pyridyl- and Piperidyl-histamines The three 2-substituted histamine isomers of piperidyl-(7) as well as pyridyl-histamines (6) were synthesized from the corresponding 2-substituted 4-hydroxymethyl-imidazoles (8) or 4-(2-hydroxyethyl)-imidazoles (3) by two different ways and tested for their histamine-like activity.

Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 12 Mitt.: Imidazo[4,5-g]chinoline

1975

Es werden zwei Wege zur Darstellung des Heterotrizyklus Imidazo[4,5-g]chinolin (8b) sowie zwei seiner partiell reduzierten Derivate 5,6,7,8-Tetrahydro-imidazo[4,5-g]chinolin (8c) und 4,4a,5,6,7,8,8a,9-Octahydro-imidazo[4,5-g]chinolin (8d) beschrieben. Imidazo[4,5-g]quinolines. Two ways for the preparation of the heterotricycle imidazo[4,5-g]quinoline (8b) and two of its partially reduced derivatives, 5,6,7,8-tetrahydro-imidazo[4,5-g]quinoline (8c) and 4,4a,5,6,7,8,8a,9-octahydro-imidazo[4,5-g]quinoline (8d), are described.

2(S)-Amino-3-[1H-imidazol-4(5)-yl]propyl cyclohexylmethyl ether dihydrochloride and 2(S)-amino-3-[1H-imidazol-4(5)-yl]propyl 4-bromobenzyl ether dihy…

2000

(Cyclohexylmethyloxymethyl)(1H-imidazol-4-iomethyl)-(S)-ammonium dichloride, C(13)H(25)N(3)O(+).2Cl(-), and (4-bromobenzyl)(1H-imidazol-4-iomethyl)-(S)-ammonium dichloride, C(13)H(18)BrN(3)O(+).2Cl(-), are model compounds with different biological activities for evaluation of the histamine H3-receptor activation mechanism. Both title compounds occur in almost similar extended conformations.

The Preparation of 1,3-Divinylparabanic Acid (1,3-Divinylimidazoletrione) and its 4-Imino Derivative

1962

4-Bromophenyl 2,4-dibromophenyl ether

2002

The title compound, C12H7Br3O, belongs to a group of flame retardants known as polybrominated di­phenyl ethers (PBDE). Salient features of the packing of the title compound are infinite intermolecular Br⋯Br contact chains along the b direction.

Intramolecular cyclization of chloral allyl hemiacetal under the action of the Fe(CO)5-DMF system

1999

Chloral allyl hemiacetal undergoes cyclization in the presence of the Fe(CO)5-DMF system to form 3,3,5-trichloro-2-hydroxytetrahydropyran rather than a butyrolactone derivative.

ChemInform Abstract: Reaction of Diphenyldiazomethane with N-Methyloxy- and N-Ethyloxycarbonyl-N-(2,2,2-trichloroethylidene)amines.

2010

Reaction of the title imines with diphenyldiazomethane gives a Δ3-1,3,4-triazoline, which leads, after loss of dinitrogen, to a transient azomethine ylide. Subsequent elimination of ethyl or methyl chloroformate gives the unexpected 1,1-diphenyl-4,4-dichloro-2-aza-1,3-butadiene.

Bis[indanyl]- and bis[indenyl]arylmethanes: New molecular three-bladed propellers

1991

Proton-catalyzed arylmethylation of indan and indene derivatives with 4-methoxybenzaldehyde yield novel triarylmethanes bearing indan or indene substituents. According to Mislow's definition, these molecules belong to the class of molecular three-bladed propellers and exhibit an interesting stereochemistry.

NMR-Spektroskopie an Heterocyclen, 2. Mitt. Kernalkylierte und isomere Nicethamidderivate

1976

Von kernalkylierten und isomeren Nicethamidderivaten wurden die 13C-NMR-Shiftwerte ermittelt und mit Hilfe der 1H-NMR-Spektroskopie die Energiebarriere bei der gehinderten Rotation der Amidgruppe bestimmt. Ringalkylated and Isomeric Nicethamide Derivatives The 13C-n.m.r. shifts were determined for ringalkylated and isomeric nicethamide derivatives and the energy barrier of the hindered rotation of the amide group was evaluated by means of 1H-n.m.r.