Search results for "misoprostol"
showing 8 items of 8 documents
Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cro…
2023
The aim of this study was to evaluate the effect of maternal age and body mass index (BMI) on induction of labor with oral misoprostol for premature rupture of membrane (PROM) at term. We have conducted retrospective cross-sectional study, including only term (37 weeks or more of gestation) PROM in healthy nulliparous women with a negative vaginal-rectal swab for group B streptococcus, a single cephalic fetus with normal birthweight, and uneventful pregnancy that were induced after 24 h from PROM. Ninety-one patients were included. According to the multivariate logistic regression, age and BMI odds ratio (OR) for induction success were 0.795 and 0.857, respectively. The study population was…
The protective role ofOcimum basilicumL. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor defic…
2018
The gastroprotective effect of Ocimum basilicum L. (Basil) hexane extract (OBHE) in aspirin-induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were determined. Pretreatment with OBHE (100 or 200 mg kg-1) or misoprostol (50 μg kg-1) alleviated the aspirin-induced oxidative stress by significantly decreasing (p < 0.001) gastric ulcer index scores (57, 76 and 79%), gastric TBARS (by 49, 51 and 52%), NO (21, 28 and 29%), H2O2 (24, 42 and 45%), and the serum pro-inflammatory mediator TNF-α (21, 53 and 53%) and IL-6 (29, 30 and 31%), as well as by markedly increasing gastric GSH (41, 61 and 70%), GSH-Px (21, 32 and 34%), GST (33, 63 and 70%), GR (90, 99 and 112%)…
Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
2020
A healthy intestinal barrier prevents uptake of allergens and toxins, whereas intestinal permeability increases following chemotherapy and in many gastrointestinal and systemic diseases and disorders. Currently, there are no approved drugs that target and repair the intestinal epithelial barrier while there is a medical need for such treatment in gastrointestinal and related conditions. The objective of this single-pass intestinal perfusion study in rats was to investigate the preventive cytoprotective effect of three mucosal protective drugs&mdash
Missed abortion etioloģija, gestācijas laiks un terapijas izvēle
2021
Ievads: Nenoticis aborts (NA) ir embrija vai augļa bojāeja pirms pilnām 22 gestācijas nedēļām bez augļa olas izstumšanas no dzemdes. Tā ir bieži sastopama agrīnas grūtniecības komplikācija, kas skar sievietes reproduktīvā vecumā gan Latvijā, gan visā pasaulē. NA ir sastopams aptuveni 15 % no visām klīniski diagnosticētajām grūtniecībām un sastāda aptuveni 30 % no kopējā abortu skaita un tas ir otrais biežāk reģistrētais aborta veids Latvijas slimnīcās pēc legāla aborta. Pētījuma mērķis: Izpētīt vai pacientēm, kuras saņēma misoprostolu pēc shēmas, kas rekomendēta NA ārstēšanai pēc FIGO, pozitīvs ārstēšanas rezultāts tiks sasniegts biežāk, nekā pacientēm, kas misoprostolu saņēma pēc citas lie…
Dzemdību indukcijas iznākumi prolongētas grūtniecības gadījumā
2018
Ievads. Apmēram 20% dzemdību Latvijā tiek inducētas, un biežākā indikācija ir pārnesta grūtniecība. Klīniskās vadlīnijas rekomendē dzemdību indukciju (DzI) sasniedzot 41+0 gestācijas nedēļu, tomēr speciālistu vidū ir domstarpības, kādā veidā mākslīga dzemdību ierosināšana var ietekmēt māti un jaundzimušo. Darba mērķis. Salīdzināt inducēto un dabīgi sākušos dzemdību iznākumus mātei un jaundzimušajam pārnestas grūtniecības gadījumā. Materiāli un metodes. Prospektīvs kohorta pētījums laika posmā no 2017.gada janvāra līdz 2018.gada martam Paula Stradiņa Klīniskās universitātes slimnīcā. Iekļaušanas kritēriji: ≥ 40+0 gestācijas nedēļām, pirmdzemdētāja, vienaugļa grūtniecība ar galvas priekšguļoš…
Medical abortion: Teratogenic effects of misoprostol.
2015
Some 40 million abortions are performed around the world every year. In Spain, this figure reached 112,390 in 2011. Of these, approximately 5% were medical abortions. This percentage varies widely ...
Instability of misoprostol tablets stored outside the blister: a potential serious concern for clinical outcome in medical abortion.
2014
IntroductionMisoprostol (Cytotec) is recognised to be effective for many gynaecological indications including termination of pregnancy, management of miscarriage and postpartum haemorrhage. Although not licensed for such indications, it has been used for these purposes by millions of women throughout the world. Misoprostol tablets are most often packaged as multiple tablets within an aluminium strip, each within an individual alveolus. When an alveolus is opened, tablets will be exposed to atmospheric conditions.ObjectiveTo compare the pharmaco technical characteristics (weight, friability), water content, misoprostol content and decomposition product content (type A misoprostol, type B mis…
Maduración pre-inducción de parto. Comparación entre dinoprostona y misoprostol con objetivación de dinámica uterina mediante electrohisterografía: U…
2019
La inducción del parto y la maduración cervical son temas de gran interés dentro de la obstetricia, llegando a alcanzar el 30% del total de nacimientos. Además, su inadecuada indicación conlleva una iatrogenia considerable respecto a los resultados neonatales, el aumento de la tasa de cesáreas y los costes. Si bien disponemos de muchos métodos con una efectividad y seguridad contrastada, la investigación en busca del método óptimo para la maduración cervical en cuellos uterinos desfavorables continúa en marcha. Actualmente las prostaglandinas Dinoprostona y Misoprostol son los agentes maduradores de primera elección en nuestro medio. Entre los diferentes estudios publicados, existe heteroge…