Search results for "modification"

Uptake of silica covered Quantum Dots into living cells: Long term vitality and morphology study on hyaluronic acid biomaterials

2015

Quantum Dots (QDs) are promising very bright and stable fluorescent probes for optical studies in the biological field but water solubility and possible metal bio-contamination need to be addressed. In this work, a simple silica-QD hybrid system is prepared and the uptake in bovine chondrocytes living cells without any functionalization of the external protective silica shield is demonstrated. Moreover, long term treated cells vitality (up to 14 days) and the transfer of silica-QDs to the next cell generations are here reported. Confocal fluorescence microscopy was also used to determine the morphology of the so labelled cells and the relative silica-QDs distribution. Finally, we employ sil…

Jet correlations: opportunities and pitfalls

2014

The simplest observables used to probe the interaction of hard partons with a QCD medium in ultrarelativistic heavy ion collisions measure disappearance, such as the nuclear modification factor R_AA. The information content of such observables is however limited. More differential information is obtained from triggered correlation observables where a trigger condition ensures that a hard event has taken place and the correlation of other objects in the event with the trigger contains information about the nature of parton-medium interaction. By construction, triggered correlation observables are conditional probabilities, i.e. they measure events biased by the trigger condition. The presenc…

Modeling the Impact Parameter Dependence of the nPDFs With EKS98 and EPS09 Global Fits

2013

So far the nuclear PDFs (nPDFs) in the global DGLAP fits have been taken to be spatially independent. In this work, using the $A$-dependence of the globally fitted sets EPS09 and EKS98, we have determined the spatial dependence of the nPDFs in terms of powers of the nuclear thickness functions. New spatially dependent nPDF sets EPS09s (NLO, LO, error sets) and EKS98s (LO) are released. As an application, we consider the nuclear modification factor $R_{dAu}^{\pi^0}$ at midrapidity for neutral pion production in deuteron-gold collisions at RHIC in NLO. Comparison with the PHENIX data in different centrality classes is also shown. In addition, predictions for the corresponding nuclear modifica…

Recent results from PHENIX on the evolution of hot QCD

2014

The Relativistic Heavy Ion Collider’s (RHIC) energy scan program explores the phase transition between the hadron gas and the quark gluon plasma phases by varying center-of-mass energies from √sNN = 7.7 to 200 GeV and using various system sizes. The nuclear modification factor of π0 and the azimuthal anisotropy of charged hadrons were measured in Au+Au collisions at c.m. energies √sNN = 39, 62.4 and 200 GeV. In addition, we present recent results of direct photon yield and anisotropy measurements in Au+Au collisions at c.m. energy √sNN = 200 GeV.

From RHIC to LHC

2007

Measurements of the nuclear modification factor of inclusive yields of $\pi^0$, $p\bar{p}$, non-phtonic electrons and prompt photon measured at RHIC are reviewed. Some of the difficulties arising from interpretation of these measurements such as similarity of the suppression pattern of light and heavy quarks, quarks and gluons, light quarks and prompt photon are discussed. The potential of two-particle and promt photon correlation technique to unravel some of these open questions is presented. An emphasis is given to the influence of partonic transverse momentum on the prompt-photon correlations. The smearing between the trigger photon and back-to-back jet at LHC energy is discussed.

Pseudouridine: Still mysterious, but never a fake (uridine)!

2014

International audience; Pseudouridine () is the most abundant of >150 nucleoside modifications in RNA. Although was discovered as the first modified nucleoside more than half a century ago, neither the enzymatic mechanism of its formation, nor the function of this modification are fully elucidated. We present the consistent picture of synthases, their substrates and their substrate positions in model organisms of all domains of life as it has emerged to date and point out the challenges that remain concerning higher eukaryotes and the elucidation of the enzymatic mechanism.

Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine

2015

Dnmt2 enzymes are cytosine-5 methyltransferases that methylate C38 of several tRNAs. We report here that the activities of two Dnmt2 homologs, Pmt1 from Schizosaccharomyces pombe and DnmA from Dictyostelium discoideum, are strongly stimulated by prior queuosine (Q) modification of the substrate tRNA. In vivo tRNA methylation levels were stimulated by growth of cells in queuine-containing medium; in vitro Pmt1 activity was enhanced on Q-containing RNA; and queuine-stimulated in vivo methylation was abrogated by the absence of the enzyme that inserts queuine into tRNA, eukaryotic tRNA-guanine transglycosylase. Global analysis of tRNA methylation in S. pombe showed a striking selectivity of Pm…

Editorial: The Role of Protein Post-Translational Modifications in Protein-RNA Interactions and RNP Assemblies

2022

Influence of the e-beam irradiation and photo-oxidation aging on the structure and properties of LDPE-OMMT nanocomposite films

2012

Abstract In this paper two systems, polyethylene (LDPE) and polyethylene/commercial organo-modified montmorillonite (LDPE/OMMT) nanocomposite, were subjected to e-beam irradiation at different doses and both the molecular modifications and mechanical properties have been investigated through solubility, FT-IR, calorimetric and tensile tests. Moreover, in some of the irradiated systems photo-oxidation aging was performed and its effects were studied. The results show an enhancement with irradiation of the positive effect of the nano-filler loading, related to the increase of the mechanical properties, due to the increase of the nano-filler polymer interaction. Nevertheless calorimetric and F…

Unravelling Radicals Reactivity Towards Carbon Nanotubes Manipulation/Functionalization

2016

Carbon Nanotubes (CNTs) chemistry is under constant evolution, as a consequence of the deep interest of the scientific community in finding new applications for these versatile materials. New and old synthetic protocols are used for improving the control of the functionalization degree of the final materials and for offering to scientists the possibility to fine-tune their final properties. In this Review, we focus the attention on radical reactions, a class of protocols characterized by small number of steps, different degrees of functionalization and enhanced solubility of the final modified CNTs, in the desired environment. The most well-known protocols are analysed providing some releva…