Search results for "moral"
showing 10 items of 1471 documents
Usted no, señor Kissinger
2001
RECENSIONE DI MASSIMO LA TORRE, NOSTRA LEGGE È LA LIBERTÀ. ANARCHISMO DEI MODERNI, DERIVE APPRODI, ROMA 2017
2018
Il testo qui recensito costituisce un sasso nello stagno del dibattito sulla giustificazione delle istituzioni giuridiche, sasso lanciato da uno dei più eminenti filosofi del diritto italiani. Il sasso è costituito dalla dottrina politica “anti-giuridica” per definizione: l’anarchismo. E che tale sasso sia lanciato in uno “stagno”, e non in un “torrente” di idee, ci sembra dato dal fatto che ormai sembra cristallizzato un consenso generale tra i filosofi del diritto circa il primato del liberalismo politico (J. Rawls), o di forme di repubblicanesimo parassitarie del liberalismo politico (J. Habermas), su altre dottrine politiche alternative quando si discute dell’obbligo di obbedire al diri…
IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
2012
Vγ9Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and display pleiotropic features. Here we report that coculture of Vγ9Vδ2 cells with phosphoantigen and IL-21 leads to selective expression of the transcription repressor Bcl-6 and polarization toward a lymphocyte subset displaying features of follicular B-helper T (T(FH)) cells. T(FH) like Vγ9Vδ2 cells have a predominant central memory (CD27(+)CD45RA(-)) phenotype and express ICOS, CD40L and CXCR5. Upon antigen activation, they secrete IL-4, IL-10 and CXCL13, and provide B-cell help for antibody production in vitro. Our findings delineate a subset of human Vγ9Vδ2 lymphocytes, which, upon interaction w…
Study of the antitumor effect of inducible nitric oxide synthase in a breast cancer model : analysis of molecular mechanisms
2013
The anti -tumor effect of a lipid A, OM -174 (lipid portion of LPS) was studied in a model of breast cancer in mice. In vivo, OM- 174 increases the survival of mice whereas in vitro it is not toxic to cancer cells. OM -174 binds to TLR4 immune cells inducing the production of cytokines such as IFNγ. In vitro, the combination of IFNγ to lipid A is cytotoxic. The objective of this thesis is to analyze those molecular mechanisms. We have shown both in vitro and in vivo that the cytotoxicity of the lipid A / IFNγ is dependent of TLR4 and of the receptor for IFNγ, and the NOS II expression. We also showed that the radical species, NO and superoxide anion forming peroxynitrite play a crucial role…
Microarray analysis of antibodies induced with synthetic antitumor vaccines : specificity against diverse mucin core structures
2017
Glycoprotein research is pivotal for vaccine development and biomarker discovery. Many successful methodologies for reliably increasing the antigenicity toward tumor-associated glycopeptide structures have been reported. Deeper insights into the quality and specificity of the raised polyclonal, humoral reactions are often not addressed, despite the fact that an immunological memory, which produces antibodies with cross-reactivity to epitopes exposed on healthy cells, may cause autoimmune diseases. In the current work, three MUC1 antitumor vaccine candidates conjugated with different immune stimulants are evaluated immunologically. For assessment of the influence of the immune stimulant on a…
Vivere è amare. La dignità dell'uomo nella prospettiva cristologica di Augustin Guillerand
2010
La antropología como ciencia libidinosa. Diderot y el viaje de Bougainville
2005
Son innumerables los estudios que han abordado, desde temprano, la historia de la constitución de la antropología como disciplina empírica con vocación 'científica', como una de las ciencias humanas. Se muestra así una cierta obsesión por los orígenes, quizá síntoma de una frágil identidad. Uno de esos textos, de los más tempranos, The History of Anthropology} 1 fue escrito por Boas justo al principio del siglo pasado (1904) y tiene por objeto -fue una conferencia dada ante un publico académico variopintoreflexionar históricamente sobre una disciplina que todavía se debate para delimitar cuál es su objeto y método epistemológicos. Boas advierte desde el principio que no va a proceder dicien…
Temporal Trends in Transcatheter Aortic Valve Replacement in France
2017
Background - Transcatheter aortic valve replacement (TAVR) is standard therapy for patients with severe aortic stenosis who are at high surgical risk. However, national data regarding procedural characteristics and clinical outcomes over time are limited. Objectives - The aim of this study was to assess nationwide performance trends and clinical outcomes of TAVR during a 6-year period. Methods - TAVRs performed in 48 centers across France between January 2013 and December 2015 were prospectively included in the FRANCE TAVI (French Transcatheter Aortic Valve Implantation) registry. Findings were further compared with those reported from the FRANCE 2 (French Aortic National CoreValve and Edwa…
Filosofia, alterità, democrazia
2021
This article intends to analyze the link existing in Apel between ethics of communication, democracy and difference. In the German author, the argumentative reason is not circumventable. The communicative and intersubjective nature of human identity founds democracy as a form of life and just coexistence. Democracy allows the individual to discover himself as tied to a common history. The paradigm of communicative philosophy overcomes both social nihilism and the dogmatism of some versions of liberalism. This rediscovery of philosophy is connected to the possibility of a social ethics and a free, equal and democratic public discourse.The problems facing today's world cannot find an adequate…