Search results for "nucleus"
showing 10 items of 1803 documents
Intra- and extra-cellular DNA damage by harmine and 9-methyl-harmine
2014
It is known that b-carbolines are able to produce photosensitized damage in cell-free DNA, but there is little information on their effects on cellular DNA. Therefore, we have analyzed the DNA damage produced by harmine and 9-methyl-harmine under UVA irradiation in V79 cells, together with the associated generation of micronuclei and photocytotoxicity. The results indicate that the most frequent photoproducts generated in the cellular DNA are modified purines such as 8-oxo-7,8-dihydroguanine. Only relatively few single-strand breaks were observed. CPDs were absent, although they were generated in cell-free DNA irradiated under the same conditions. The overall extent of DNA damage in the cel…
Place de l’imagerie dans l’évaluation de l’efficacité des traitements dans le cancer du sein
2010
Resume Cette revue decrit le role de differentes methodes d’imagerie pour evaluer la reponse au traitement dans le cancer du sein. Deux situations sont envisageables : celle de la chimiotherapie neoadjuvante du cancer du sein et celle des metastases. Beaucoup de donnees cliniques sont disponibles pour trois criteres : le volume de la tumeur, la captation du fluorodeoxyglucose mesuree en TEP et la perfusion de la tumeur evaluee soit par IRM dynamique, soit en TEP. La TEP au 2-18F fluoro-2-desoxy-D-glucose (FDG) permet la prediction de la reponse apres une ou deux cures de chimiotherapie. De nouvelles approches pourraient prochainement affiner le role de l’imagerie. Ainsi, la TEP a la thymidi…
The diagnostic significance of intrahepatocellular hepatitis-B-surface-antigen (HB s Ag), hepatitis-B-core-antigen (HB c Ag) and IgG for the classifi…
1975
Liver biopsies of patients with inflammatory liver diseases and clinically healthy HBsAg-carriers were examined for presence of intracellular HBsAg, HBcAg and IgG by direct immunofluorescence. The studies revealed the following results: 1. In most cases healthy HBsAg-carriers had HBsAg in the cytoplasm, but they did never show HBcAg in the nuclei of hepatocytes. 2. In the early phase some patients with HBsAg-positive acute hepatitis had HBcAg and/or HBsAg in their hepatocytes. In a normal course with complete recovery the immunoelimination may clear either phenomenon at variable stages of the disease. 3. Cases one year after complete recovery of acute virus B-hepatitis had no HB-components …
Gamow-Teller response in the configuration space of a density-functional-theory–rooted no-core configuration-interaction model
2018
Background: The atomic nucleus is a unique laboratory in which to study fundamental aspects of the electroweak interaction. This includes a question concerning in medium renormalization of the axial-vector current, which still lacks satisfactory explanation. Study of spin-isospin or Gamow-Teller (GT) response may provide valuable information on both the quenching of the axial-vector coupling constant as well as on nuclear structure and nuclear astrophysics.Purpose: We have performed a seminal calculation of the GT response by using the no-core configuration-interaction approach rooted in multireference density functional theory (DFT-NCCI). The model treats properly isospin and rotational sy…
Searches for transverse momentum dependent flow vector fluctuations in Pb-Pb and p-Pb collisions at the LHC
2017
The measurement of azimuthal correlations of charged particles is presented for Pb-Pb collisions at $\sqrt{s_{\rm NN}}=$ 2.76 TeV and p-Pb collisions at $\sqrt{s_{\rm NN}}=$ 5.02 TeV with the ALICE detector at the CERN Large Hadron Collider. These correlations are measured for the second, third and fourth order flow vector in the pseudorapidity region $|��|<0.8$ as a function of centrality and transverse momentum $p_{\rm T}$ using two observables, to search for evidence of $p_{\rm T}$-dependent flow vector fluctuations. For Pb-Pb collisions at 2.76 TeV, the measurements indicate that $p_{\rm T}$-dependent fluctuations are only present for the second order flow vector. Similar results hav…
A search for anisotropy in the arrival directions of ultra high energy cosmic rays recorded at the Pierre Auger Observatory
2012
Observations of cosmic ray arrival directions made with the Pierre Auger Observatory have previously provided evidence of anisotropy at the 99% CL using the correlation of ultra high energy cosmic rays (UHECRs) with objects drawn from the Véron-Cetty Véron catalog. In this paper we report on the use of three catalog independent methods to search for anisotropy. The 2pt–L, 2pt+ and 3pt methods, each giving a different measure of selfclustering in arrival directions, were tested on mock cosmic ray data sets to study the impacts of sample size and magnetic smearing on their results, accounting for both angular and energy resolutions. If the sources of UHECRs follow the same large scale structu…
Soft-dielectron excess in proton-proton collisions at $\sqrt{s}$ = 13 TeV
2021
Physical review letters 127(4), 042302 (2021). doi:10.1103/PhysRevLett.127.042302
Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds
1990
Activities of various xenobiotic-metabolizing enzymes were determined in 18 cell lines. Activities of cytochrome P450 reductase, microsomal epoxide hydrolase and glutathione transferase were detectable in all lines. The highest values were similar to the activities found in freshly isolated rat hepatocytes. Catalase activity was also present in all 12 investigated cell lines. Activity of UDP-glucuronosyl transferase was high in some lines, but low or undetectable in others. Activity of cytosolic epoxide hydrolase was not measurable in most lines, and was low in the others. Metabolism of benzo[a]pyrene was observed in eight out of nine examined lines, no activity being found in V79 cells. V7…
The effect of the in-medium Θ+ pentaquark on the kaon optical potential
2005
The kaon nuclear optical potential is studied including the effect of the $\Theta^+$ pentaquark. The one-nucleon contribution is obtained using an extension of the J\"ulich meson-exchange potential as bare kaon-nucleon interaction. Significant differences between a fully self-consistent calculation and the usually employed low-density $T\rho$ approach are observed. The influence of the one-nucleon absorption process, $K N \to \Theta^+$, on the kaon optical potential is negligible due to the small width of the pentaquark. In contrast, the two-nucleon mechanism, $K N N \to \Theta^+ N$, estimated from the coupling of the pentaquark to a two-meson cloud, provides the required amount of addition…
Overlooked cryptic endemism in copepods: Systematics and natural history of the calanoid subgenus Occidodiaptomus Borutzky 1991 (Copepoda, Calanoida,…
2012
Abstract Our comprehension of the phylogeny and diversity of most inland–water crustaceans is currently hampered by their pronounced morphological bradytely, which contributed to the affirmation of the “Cosmopolitanism Paradigm” of freshwater taxa. However, growing evidence of the existence of cryptic diversity and molecular regionalism is available for calanoid copepods, thus stressing the need for careful morphological and molecular studies in order to soundly investigate the systematics, diversity and distribution patterns of the group. Diaptomid copepods were here chosen as model taxa, and the morphological and molecular diversity of the species belonging to the west-Mediterranean diapt…