Search results for "oie"
showing 10 items of 1669 documents
Hacia una metodología del análisis crítico del discurso desde la enacción aplicada al género y la traducción: Una visión liminar en Bridget Jones. Ma…
2023
En esta investigación se abordan los presupuestos biológico-cognitivos de la Enacción y se refieren a un sistema lingüístico-perceptivo mediante la Gramática Liminar (GL) y el Análisis Crítico del Discurso (ACD) aplicado al estudio enactivo entre Bridget Jones. Mad about The Boy (2013) y Bridget Jones. Loca por él, de H. Fielding. Analizamos cómo la enacción sexista resulta de la forma sistémica de comunicarnos, incardinada en el cuerpo como matriz cognitiva biológica-cultural, donde el lenguaje actúa como bucle de retroalimentación en perpetua intratraducción entre el ser/mundo y viceversa, y se configura en lenguas de cuya intertraducción depende el grado de connotación sexista. This rese…
Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors
2016
Novel rhodesain inhibitors were developed by combining an enantiomerically pure 3-bromoisoxazoline warhead with a 1,4-benzodiazepine scaffold as specific recognition moiety. All compounds were proven to inhibit rhodesain with Ki values in the low-micromolar range. Their activity towards rhodesain was found to be coupled to an in vitro antitrypanosomal activity, with IC50 values ranging from the mid-micromolar to a low-micromolar value for the most active rhodesain inhibitor (R,S,S)-3. All compounds showed a good selectivity against the target enzyme since all of them were proven to be poor inhibitors of human cathepsin L. Novel rhodesain inhibitors were developed by combining an enantiomeri…
Agroresursu un ekonomikas institūta saimnieciskās darbības analīze un produktu noieta veicināšana.
2018
Agroresursu un ekonomikas institūts ir reorganizācijas rezultāts, konsolidējot divus institūtus ar specializāciju selekcijas un laukkopības pētījumu jomā un pievienojot institūtu, kurš specializējies starpnozaru pētījumos ekonomikā, t.sk. bioekonomikā. Tādējādi ir samazināta līdzšinējā sadrumstalotība laukaugu selekcijas pētījumos Latvijā, turpmāk tos attīstot AREI, kā vienīgajā pētniecības centrā Latvijā. Darba nosaukums ir “Agroresursu un ekonomikas institūta saimnieciskās darbības analīze un produktu noieta veicināšana”. Darba autore Dace Maizīte. Darba mērķis ir izpētīt saimnieciskās darbības efektivitāti, analizēt AREI darbību un vidi, kurā uzņēmums darbojas, kā arī noteikt tālāko pasā…
Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(
2019
The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. These lipid-like 1,4-DHPs have been earlier proposed as promising nanocarriers for DNA delivery. We have revealed that the mean diameter of freshly prepared nanoparti…
Compte rendu de : Delphine Cano et Nathalie Foron-Dauphin (dir.), Habiter l’usine. Voyage au cœur du logement ouvrier, Paris-Bourg-en-Bresse, Somogy-…
2019
International audience
BODIPY atropisomer interconversion, face discrimination, and superstructure appending
2016
International audience; A strategy was developed to append sterically hindered apical pickets on both faces of the BODIPY platform to prevent stacking and aggregation. Ortho-substitution of both the meso-phenyl ring and the boron-bound catechol affords the right directionality to append pickets, achieve face discrimination, featuring two inter-convertible atropisomers, and is reminiscent of the picket-fence strategy in porphyrins.
Realizzazione di una stazione di misura delle aree proiettate del corpo umano
2003
Ergonomiskie un psihosociālie riski autoiekrāvēju vadītājiem un to samazināšanas iespējas
2019
Maģistra darba nosaukums: “Ergonomiskie un psihosociālie riski autoiekrāvēju vadītājiem un to samazināšanas iespējas”. Darba autore: Jekaterina Semenihina. Darba zinātniskā vadītāja: asoc. prof., Dr.med. Ženija Roja. Darbs izklāstīts uz 64. lpp., ietver 19. attēlus, 14. tabulas, 5. pielikumus, 31. informatīvs avots. Pētijumā tiek apskatīti transporta nozarē nodarbinātie - frontālo autoiekrāvēju vadītāji, kas strādā ostu teritorijās. Tēmas aktualitāti nosaka Latvijas ostu darbības nepartrauktā attīstība, par ko liecinā transportējāmo krāvu apjomu izaugsme pēdējos gados. Līdz ar to, Latvijas apstākļos nodarbināto speciālistu darbspēju uzturēšana, saglabāšana un uzlabošana ir aktuālas darba de…
Studies in organic mass spectrometry. Part 23. Role of the aroyl group on the competitive fragmentation reactions of the molecular ion of aroylanilid…
1999
The 70 eV and mass-analysed ion kinetic energy (MIKE) spectra of some thiophenecarboxanilides and benzoylanilides (1–10) have been compared in order to investigate the role of the aroyl (or heteroaroyl) moiety on the abundance of the competitive fragmentation reactions occurring in their molecular ions (amide–bond cleavage and phenol radical ion formation). It has been shown that the electron ionisation induced decompositions with high (70 eV) and low (MIKE) internal energy excess are qualitatively similar, but remarkable quantitative differences have been observed that can be accounted for in terms of the different effectiveness in the transmission of electronic effects of substituents in …
Sulfonamide moiety as "molecular chimera" in the design of new drugs.
2021
Background: The -SO2NH- group is of great significance in modern pharmaceutical use since, in sulfa-drugs, it is possible to introduce easily chemical modifications, and even small changes may lead to an improved version of an already existing drug. Objective: This paper aims to describe updated information in the sulfonamide field with a particular focus on new mechanisms of action, especially if discovered by employing computational approaches. Methods: Research articles that focused on the use of the sulfonamide moiety for the design, synthesis, and in vitro/in vivo tests of various diseases were collected from various search engines like PubMed, Science Direct, Google Scholar, and Scop…