Search results for "perspective"
showing 10 items of 1523 documents
On the Locality of Standard Search Operators in Grammatical Evolution
2014
Offspring should be similar to their parents and inherit their relevant properties. This general design principle of search operators in evolutionary algorithms is either known as locality or geometry of search operators, respectively. It takes a geometric perspective on search operators and suggests that the distance between an offspring and its parents should be less than or equal to the distance between both parents. This paper examines the locality of standard search operators used in grammatical evolution (GE) and genetic programming (GP) for binary tree problems. Both standard GE and GP search operators suffer from low locality since a substantial number of search steps result in an o…
Radiomics and Prostate MRI: Current Role and Future Applications
2021
Multiparametric prostate magnetic resonance imaging (mpMRI) is widely used as a triage test for men at a risk of prostate cancer. However, the traditional role of mpMRI was confined to prostate cancer staging. Radiomics is the quantitative extraction and analysis of minable data from medical images; it is emerging as a promising tool to detect and categorize prostate lesions. In this paper we review the role of radiomics applied to prostate mpMRI in detection and localization of prostate cancer, prediction of Gleason score and PI-RADS classification, prediction of extracapsular extension and of biochemical recurrence. We also provide a future perspective of artificial intelligence (machine …
Blockchain-Based Decentralized Business Models in the Sharing Economy: A Technology Adoption Perspective
2018
Recently, blockchain technology has increasingly been deemed to enable novel “decentralized” business models for the sharing economy and thereby potentially provide an alternative to extant “centralized” sharing economy business models. Using a technology adoption perspective, our chapter explores under which circumstances such blockchain-based decentralized sharing economy business models may be widely adopted. Building on extant research, we theorize on the factors that are relevant for adoption from the individual users’ perspective. We then derive eight potential adoption scenarios of blockchain-based decentralized sharing economy business models and explore adoption using an agent-base…
Bipolar disorder: A neural network perspective on a disorder of emotion and motivation
2013
Bipolar disorder (BD) is a severe, chronic disease with a heritability of 60-80%. BD is frequently misdiagnosed due to phenomenological overlap with other psychopathologies, an important issue that calls for the identification of biological and psychological vulnerability and disease markers. Altered structural and functional connectivity, mainly between limbic and prefrontal brain areas, have been proposed to underlie emotional and motivational dysregulation in BD and might represent relevant vulnerability and disease markers. In the present laboratory review we discuss functional and structural neuroimaging findings on emotional and motivational dysregulation from our research group in BD…
Rhizosphere: achievements and challenges
2009
Reprinted from Plant and Soil, Vol.321, nos 1-2; International audience
L'assistente alla comunicazione nella scuola è solo un mediatore linguistico? Problemi, specificità, formazione di una nuova figura professionale.
2009
In seguito all’applicazione della L.104/92 sull’integrazione dei soggetti in situazione di handicap, sono presenti nelle scuole italiane gli “assistenti alla comunicazione” per gli alunni sordi: si tratta di una nuova figura professionale che, all’interno dei servizi educativi, si propone di far da ponte tra sordi e udenti, in quanto esperto delle principali problematiche degli alunni sordi ed esperto nella LIS (Lingua dei Segni Italiana). Ma di che tipo di mediazione si tratta? Quali problemi solleva e quali riflessioni dal punto di vista pedagogico, sociale, linguistico e antropologico? Questi i principali ambiti di riflessione trattati all’interno dell’articolo, in termini problematici e…
Investigación inter e intra-variable del valor percibido: un modelo causal de segundo orden y satisfacción cognitiva y afectiva
2017
El valor percibido es axiomática y epistemológicamente clave para el Marketing. Su investigación es rica y profunda respecto a su dimensionalidad (análisis intra-variable) y a su relación con satisfacción y lealtad (inter-variable). Como contribución a la abundante literatura sobre medición del valor percibido en servicios turísticos, este trabajo propone un modelo causal que abarca las perspectivas inter e intra-variable, y propone el valor percibido como segundo orden y la cadena valor-satisfacción-lealtad, con una bifurcación de la satisfacción en afectiva y cognitiva. El modelo es testado con PLS sobre una muestra de 340 huéspedes de hotel en la Comunidad Valenciana, hallando contribuci…
Precision sampling fuels precision oncology: an evolutionary perspective.
2021
Intratumor heterogeneity (ITH) develops in malignant tumors. Precision sampling that captures this tumor variability is essential for the implementation of precision oncology. We highlight the necessity to update current sampling protocols and implement a strategy to ensure ITH detection and characterization. A cost-effective strategy for such sampling has been modeled in clear cell renal cell carcinoma (CCRCC).
EML4-ALK translocation identification in RNA exosomal cargo (ExoALK) in NSCLC patients: A novel role for liquid biopsy
2019
Abstract: The introduction of druggable targets has significantly improved the outcomes of non-small cell lung cancer patients (NSCLC). EML4-ALK translocation represents 4-6% of the druggable alterations in NSCLC. With the approval of Crizotinib, first discovered drug for the EML4-ALK translocation, on first line treatment for patients with detected mutation meant a complete change on the treatment landscape. The current standard method for EML4-ALK identification is immunohistochemistry or FISH in a tumor biopsy. However, a big number of NSCLC patients have not tissue available for analysis and others are not suitable fir biopsy due to their physical condition or the location of the tumor.…
Targeting cancer with peptide aptamers
2011
Renaud Seigneuric 1,2 , Jessica Gobbo 1,2 , Pierre Colas 3 , Carmen Garrido 1,2 1 Heat Shock Proteins and Cancer, INSERM, UMR 866 IFR 100, Faculty of Medicine, 7 Boulevard Jeanne D'Arc, 21000 Dijon, France 2 Universite de Bourgogne, Dijon, France 3 CNRS USR 3151, P2I2 Group, Station Biologique, Roscoff, Bretagne, France Received: June 22, 2011; Accepted: June 24, 2011; Published: June 24, 2011; Correspondence: Renaud Seigneuric, email: // // Abstract A major endeavour in cancer chemotherapy is to develop agents that specifically target a biomolecule of interest. There are two main classes of targeting agents: small molecules and biologics. Among biologics (e.g.: antibodies), DNA, RNA but al…