Search results for "quine"
showing 10 items of 140 documents
Efficacy of Caplacizumab in Patients with aTTP in the HERCULES Study According to Initial Immunosuppression Regimen
2019
Background: Acquired thrombotic thrombocytopenic purpura (aTTP) is an acute, life-threatening thrombotic microangiopathy that requires urgent and specialized treatment. Prior to the introduction of caplacizumab, the treatment for aTTP was based on daily therapeutic plasma exchange (TPE; to replenish functional ADAMTS13 enzyme) plus immunosuppression (mainly corticosteroids and rituximab; to suppress anti-ADAMTS13 autoantibody production). TPE combined with immunosuppressive therapy improved outcomes in patients; however, episodes of aTTP are still associated with an acute mortality of up to 20% as these therapies do not have an immediate effect on the pathologic microvascular thrombosis. Th…
Hyperpigmentation of hard palate induced by chloroquine therapy
2017
The antimalarials are one of the most commonly prescribed drugs for conditions such as lupus erythematosus and rheumatoid arthritis, and the side effects, though infrequent, are well known. The antimalarial agent chloroquine diphosphate usually causes pigmentary changes in the oral mucosa characterized by a bluish-grey to black discolorations mainly in the hard palate. Considering only the hard palate hyperpigmentation caused by chloroquine, to the best of our knowledge, only 13 cases have been reported in the English language literature. We described an additional case of palate hyperpigmentation related to the chronic use of chloroquine diphosphate in a 60-year-old Mexican woman. Although…
High-Speed Video Microscopy for Primary Ciliary Dyskinesia Diagnosis: A Study of Ciliary Motility Variations with Time and Temperature
2021
Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2075-4418/11/7/1301 Este artículo de investigación pertenece al número especial "Progress in Diagnosing and Managing Primary Ciliary Dyskinesia". Primary ciliary dyskinesia (PCD) is a rare disease resulting from a defect in ciliary function that generates, among other issues, chronic upper and lower respiratory tract infections. European guidelines recommend studying ciliary function (pattern (CBP) and frequency (CBF)), together with characteristic clinical symptoms, as one of the definitive tests. However, there is no “gold standard”. The present study aims to use high-speed video microscopy to describe how CBF…
Clinical characteristics of patients hospitalized with COVID-19 in Spain: results from the SEMI-COVID-19 Network
2020
ABSTRACTBackgroundSpain has been one of the countries most affected by the COVID-19 pandemic.ObjectiveTo create a registry of patients with COVID-19 hospitalized in Spain in order to improve our knowledge of the clinical, diagnostic, therapeutic, and prognostic aspects of this disease.MethodsA multicentre retrospective cohort study, including consecutive patients hospitalized with confirmed COVID-19 throughout Spain. Epidemiological and clinical data, additional tests at admission and at seven days, treatments administered, and progress at 30 days of hospitalization were collected from electronic medical records.ResultsUp to April 30th 2020, 6,424 patients from 109 hospitals were included. …
Systemic immunosuppression in times of COVID‐19: Do we need to rethink our standards?
2020
Summary The current SARS‐CoV‐2 pandemic particularly endangers older people with pre‐existing cardiopulmonary and metabolic conditions. However, it is also currently under discussion whether patients under immunosuppressive therapy also have a higher risk of suffering a severe course of the COVID‐19 disease. In principle though, there is currently no data available for a general reduction or pause of immunosuppression in patients with autoimmune diseases because of the SARS‐CoV‐2 pandemic. However, since there is currently neither an effective therapy nor corresponding vaccination protection, the indication for a prolonged immunosuppressive therapy should be made with special care. In parti…
Neonatal Respiratory Insufficiency Caused by an (Homozygous) ABCA3-Stop Mutation: a Systematic Evaluation of Therapeutic Options
2014
Background Autosomal recessive ABCA3 (ATP-binding cassette protein A3) gene mutations have been associated with neonatal respiratory distress and pediatric interstitial lung disease. The clinical course of the disease depends on the underlying mutations. Therefore, knowledge of course, symptoms and treatment of the disease is important. Patient and methods A term newborn suffered from progressive respiratory insufficiency, which led to death at the age of 4.8 months. The girl developed interstitial lung disease. Infections as well as structural and functional disorders of the lung were systematically excluded. A homozygous c.4681C > T (Arg 1561 Stop) mutation of the ABCA3 gene was identifie…
Amphoteric polyamidoamines in the treatment of malaria
2012
The present invention relates to the use of amphoteric polyamidoamines with MW of 10-100 kDa as antimalarial agents or carriers of antimalarial drugs and to formulations thereof.
Problemes epistemològics dels condicionants prelingüístics
1994
Les reflexions que segueixen se situen en les fronteres entre ontologia, epistemologia i filosofia del llenguatge. No pot sorprendre aquesta situació: el més habitual és que els problemes filosòfics siguen problemes fronterers o, dit d'altra manera, que la reflexió filosòfica situe sempre els seus problemes allà on més s'emboliquen. The object of this paper is to carry out a criticat anatysls of the epistemological foundations of those extralinguistic elements to which it is necessary to resort in order to give an account of communication, both intratinguistic and interlinguistic. The paint of view adopted is exclusively philosophical, within the field of problems of philosophy of language,…
Role of p38α in the regulation of hepatocyte cytokinesis with age and during liver regeneration
2015
La familia p38 MAPK está constituida por un grupo de quinasas trasductoras de señales que responden a la hiperosmolaridad, la radiación ultravioleta, el choque térmico, la inhibición de la sínteis de proteínas, el estrés oxidativo y los mediadores de la inflamación. El papel de la ruta p38 MAPK durante la apoptosis, la respuesta inflamatoria y la inhibición del crecimiento y diferenciación celular es muy conocido, y ha sido objeto de revisión en numerosas ocasiones. Sin embargo, la función que desempeñan las p38 MAPKs en la regulación de la última etapa de la mitosis, es decir, la citoquinesis, es todavía desconocido. Las células poliploides son las que contienen más de dos comjuntos de cro…
Quine’s conflicts with truth deflationism
2022
AbstractCompared to the extensive amount of literature on various themes of W.V.O. Quine’s philosophy, his immanent concept of truth remains a relatively unexplored topic. This relative lack of research contributes to a persistent confusion on the deflationary and inflationary details of Quine’s truth. According to a popular reading, Quine’s disquotational definition of the truth predicate exhausts the topic of truth, thus amounting to a deflationary view. Others promote opposing interpretations. I argue that by relying on Tarski’s semantic conception of truth, Quine’s disquotational account inherits a commitment to classical correspondence intuitions. Based on this, Quine posits a firm con…