Search results for "reduction"

Functionality transfer from C8 to C9 in sesquiterpenes. Synthesis of the named Herbolide E from artemisin.

1992

Abstract The key intermediate 6 was obtained in five steps from artemisin (1). The spectroscopic characteristics of the synthetic product 7a reveal that the proposed structure for the natural herbolide E must be revised.

Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines

2004

The antimalarial artemisinins also reveal profound cytotoxic activity against tumor cells. Artemisinins harbor an endoperoxide bridge whose cleavage results in the generation of reactive oxygen species (ROS) and/or artemisinin carbon-centered free radicals. Established cancer drugs such as anthracyclines also form ROS and free radicals that are responsible for the cardiotoxicity of anthracyclines. In contrast, artemisinins do not reveal cardiotoxicity. In the present investigation, we compared the cytotoxic activities of different artemisinins (artemisinin, artesunate, arteether, artemether, artemisitene, dihydroartemisinylester stereoisomers) in 60 cell lines of the National Cancer Institu…

Stability of impulsive differential systems

2013

The asymptotic phase property and reduction principle for stability of a trivial solution is generalized to the case of the noninvertible impulsive differential equations in Banach spaces whose linear parts split into two parts and satisfy the condition of separation.

Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilis

2011

Mutant strain of the facultatively anaerobic, ethanol-producing bacteriumZymomonas mobilis, deficient in the Fe-containing alcohol dehydrogenase isoenzyme (ADH II), showed impaired homeostasis of the intracellular NAD(P)H during transition from anaerobic to aerobic conditions, and also in steady-state continuous cultures at various oxygen supplies. At the same time, ADH II deficiency in aerobically grown cells was accompanied by a threefold increase of catalase activity and by about 50% increase of hydrogen peroxide excretion. It is concluded that ADH II under aerobic conditions functions to maintain intracellular redox homeostasis and to protect the cells from endogenous hydrogen peroxide.

Biodegradability Prediction of Fragrant Molecules by Molecular Topology

2016

Biodegradability is a key property in the development of safer fragrances. In this work we present a green methodology for its preliminary assessment. The structure of various fragrant molecules is characterized by computing a large set of topological indices. Those relevant to biodegradability are selected by means of a hybrid stepwise selection method to build a linear classifier. This model is compared with a more complex artificial neural network trained with the indices previously found. After validation, the models show promise for time and cost reduction in the development of new, safer fragrances. The methodology presented could easily be adapted to many quasi-big data problems in R…

A Neural Architecture for 3D Segmentation

2003

An original neural scheme for segmentation of range data is presented, which is part of a more general 3D vision system for robotic applications. The entire process relies on a neural architecture aimed to perform first order image irradiance analysis, that is local estimation of magnitude and orientation of the image irradiance gradient.

Outer boundary conditions for Einstein's field equations in harmonic coordinates

2007

We analyze Einstein's vacuum field equations in generalized harmonic coordinates on a compact spatial domain with boundaries. We specify a class of boundary conditions which is constraint-preserving and sufficiently general to include recent proposals for reducing the amount of spurious reflections of gravitational radiation. In particular, our class comprises the boundary conditions recently proposed by Kreiss and Winicour, a geometric modification thereof, the freezing-Psi0 boundary condition and the hierarchy of absorbing boundary conditions introduced by Buchman and Sarbach. Using the recent technique developed by Kreiss and Winicour based on an appropriate reduction to a pseudo-differe…

Spatial diversity of chlorine residual in a drinking water distribution system: application of an integrated fuzzy logic technique

2014

A reduction in the concentration of chlorine, which is used as a chemical disinfectant for water in drinking water distribution systems, can be considered to be an index of the progressive deterioration of water quality. In this work, attention is given to the spatial distribution of the residual chlorine in drinking water distribution systems. The criterion for grouping the water-quality parameters normally used is highly subjective and often based on data that are not correctly identified. In this paper, a cluster analysis based on fuzzy logic is applied. The advantage of the proposed procedure is that it allows a user to identify (in an automatic way and without any specific assumption) …

2013

To identify factors limiting performance in multitone intensity discrimination, we presented sequences of five pure tones alternating in level between loud (85 dB SPL) and soft (30, 55, or 80 dB SPL). In the “overall-intensity task”, listeners detected a level increment on all of the five tones. In the “masking task”, the level increment was imposed only on the soft tones, rendering the soft tones targets and loud tones task-irrelevant maskers. Decision weights quantifying the importance of the five tone levels for the decision were estimated using methods of molecular psychophysics. Compatible with previous studies, listeners placed higher weights on the loud tones than on the soft tones i…

Video preprocessing for audiovisual indexing

2003

We address the problem of detecting shots of subjects that are interviewed in news sequences. This is useful since usually these kinds of scenes contain important and reusable information that can be used for other news programs. In a previous paper, we presented a technique based on a priori knowledge of the editing techniques used in news sequences which allowed a fast search of news stories (see Albiol, A. et al., 3rd Int. Conf. on Audio and Video-based Biometric Person Authentication, p.366-71, 2001). We now present a new shot descriptor technique which improves the previous search results by using a simple, yet efficient, algorithm, based on the information contained in consecutive fra…