Search results for "refractive errors"

showing 10 items of 57 documents

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

2018

Skin affections after sulfur mustard (SM) exposure include erythema, blister formation and severe inflammation. An antidote or specific therapy does not exist. Anti-inflammatory compounds as well as substances counteracting SM-induced cell death are under investigation. In this study, we investigated the benzylisoquinoline alkaloide berberine (BER), a metabolite in plants like berberis vulgaris, which is used as herbal pharmaceutical in Asian countries, against SM toxicity using a well-established in vitro approach. Keratinocyte (HaCaT) mono-cultures (MoC) or HaCaT/THP-1 co-cultures (CoC) were challenged with 100, 200 or 300 mM SM for 1 h. Post-exposure, both MoC and CoC were treated with 1…

0301 basic medicineAdultMaleCell typeResearchInstitutes_Networks_Beacons/MICRAIn silicotaittovirheetGenome-wide association studyRetinal Pigment EpitheliumBiologyBlindnessPolymorphism Single NucleotideSensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]ArticleRetinaWhite People03 medical and health sciencesHIGH-GRADE MYOPIA ; RETINAL-PIGMENT EPITHELIUM ; SEROTONIN PATHWAY GENES ; FORM-DEPRIVATION MYOPIA ; COMMON VARIANTS ; OCULAR GROWTH ; RETINITIS-PIGMENTOSA ; GENOTYPE IMPUTATION ; MISSENSE MUTATIONS ; DOPAMINE-RECEPTORSAsian Peoplerefractive errorsRetinitis pigmentosaGeneticsmedicineMyopiaJournal ArticleHumansGenetic Predisposition to Disease610 Medicine & healthRegulation of gene expressionRetinaRetinal pigment epitheliummedicine.diseaseRefractive Errors030104 developmental biologymedicine.anatomical_structureManchester Institute for Collaborative Research on AgeingGene Expression Regulationgenetic factorsEye disorderFemalesense organsgeneettiset tekijätNeuroscienceGenome-Wide Association StudySignal Transduction
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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

2016

Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG…

0301 basic medicineRefractive errorgenetic structuresGeneral Physics and AstronomyGenome-wide association studyVARIANTSrefractive error ; geneEYEBioinformaticsINCIDENT MYOPIAGenome-wide association studiesSensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]0302 clinical medicinePolymorphism (computer science)10. No inequalityPOPULATIONeducation.field_of_studyMultidisciplinaryQACTIVATED PROTEIN-KINASEta3142single-nucleotide polymorphismRETINAL-PIGMENT EPITHELIUMOUTDOOR ACTIVITY3142 Public health care science environmental and occupational health3. Good healthRefractive errorsMeta-analysislociEducational StatusSciencePopulation610 Medicine & healthEnvironmentBiologyta3111Polymorphism Single NucleotideArticleWhite PeopleGeneral Biochemistry Genetics and Molecular BiologyEducation03 medical and health sciencesAsian PeopleSDG 3 - Good Health and Well-beingGenetic variationmedicineHumansSNPGenetic Predisposition to Diseasemyopia3125 Otorhinolaryngology ophthalmologyGenetic variationeducationRECEPTORGene Expression Profilingta1184General ChemistryHeritabilitymedicine.diseaseeye diseasesta3125TIME OUTDOORS030104 developmental biologyGenetic LociEvolutionary biologyRISK-FACTORS030221 ophthalmology & optometryREsense organs3111 BiomedicineGenome-Wide Association StudyNature Communications
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Anisometropia of ocular refractive and biometric measures among 66- to 79-year-old female twins

2016

Purpose To examine the prevalence of anisometropia of spherical refraction (AnisoSR), astigmatism (AnisoAST) and spherical equivalent (AnisoSE) and their associations with spherical refraction (SR), refractive astigmatism (AST), spherical equivalent (SE) and interocular differences of ocular biometric parameters among elderly female twins. Methods Refraction of 117 monozygotic (MZ) and 116 dizygotic (DZ) female twin subjects aged 66–79 years was assessed with an auto-refractor (Topcon AT) and controlled by subjective refraction. Corneal refraction, anterior chamber depth and axial length were measured with a Zeiss IOL Master. Participants with eyes operated for cataract or glaucoma were exc…

0301 basic medicinemedicine.medical_specialtyBiometryemmetropizationgenetic structuresAnterior ChamberGlaucomaaxial lengthAstigmatismRefraction OcularanisometropiaelderlyocularCorrelation03 medical and health sciences0302 clinical medicineOphthalmologyDiseases in TwinsTwins DizygoticmedicineHumansAgedMathematicsAnisometropiaanisometropia of biometric measuresAstigmatismta3141Twins Monozygoticta3142General MedicineAxial lengthRefractive Errorsmedicine.diseaseSubjective refractionRefractioneye diseasesta3125corneal refractionAxial Length EyeOphthalmology030104 developmental biology030221 ophthalmology & optometryFemaleanisoastigmatismCorneal astigmatismActa Ophthalmologica
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Accuracy and accommodation capability of a handheld autorefractor

2000

Purpose: To determine the accuracy of measurement by the Nikon Retinomax handheld autorefractor and its ability to relax accommodation. Setting: Pediatric Section, Department of Ophthalmology, University of Mainz, Germany. Methods: To perform a series of comparative measurements, autorefractor readings were obtained on healthy young adults (students) and on children aged 2 to 12 years. The autorefractor readings were compared with subjective refractions of the young adults and with cycloplegic retinoscopy of the children. Results: In adults, the accuracy of the handheld autorefractor measurements was comparable to that of conventional tabletop autorefractors. In children, the autorefractor …

AdultAgingmedicine.medical_specialtygenetic structuresOcular refractionRefraction OcularOcular physiologyReference ValuesOphthalmologymedicineHumansChildDioptreRetinoscopyElectronic Data Processingmedicine.diagnostic_testbusiness.industryVision TestsAutorefractorsAccommodation OcularReproducibility of ResultsCycloplegiaRefractive ErrorsSensory SystemsOphthalmologyAutorefractorChild PreschoolOptometrySurgerymedicine.symptombusinessAccommodationJournal of Cataract and Refractive Surgery
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Depth of focus through different intraocular lenses in patients with different corneal profiles using adaptive optics visual simulation

2011

PURPOSE: To evaluate the depth of focus with monofocal intraocular lenses (IOLs) in patients with different corneal profiles using adaptive optics (AO) visual simulation. METHODS: An AO visual simulator (crx1, Imagine Eyes) was used to simulate the aberration pattern of three monofocal IOLs (Acrysof IQ SN60WF [Alcon Laboratories Inc]; Akreos Adapt AO [Bausch & Lomb]; and Triplato [AJL Ophthalmic]) of different optic designs. Five groups were considered: patients without any corneal refractive surgery (normal cornea group) and with prior low and high myopic and hyperopic ablations (low myopic ablation, high myopic ablation, low hyperopic ablation, and high hyperopic ablation groups). De…

AdultDepth of focusVisual acuityCorneal Wavefront AberrationPseudophakiagenetic structuresmedicine.medical_treatmentVisual AcuityCorneaYoung AdultLens Implantation IntraocularCorneaRefractive surgerymedicineHumansDioptreLenses IntraocularDepth Perceptionbusiness.industryAblationRefractive Errorseye diseasesOphthalmologySpherical aberrationmedicine.anatomical_structureOptometryOftalmologíaSurgerysense organsmedicine.symptomDepth perceptionbusiness
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Dynamic accommodation without feedback does not respond to isolated blur cues

2016

Highlights • A new methodology is used to study a potential cue for dynamic accommodation. • We show that human accommodation is not driven correctly by defocus alone. • Accommodation is most efficient using changes in stimulus vergence with feedback.

AdultMaleAccommodationmedicine.medical_specialtygenetic structuresComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISIONAudiologyStimulus (physiology)Article050105 experimental psychologyPupilDynamic accommodationYoung Adult03 medical and health sciences0302 clinical medicineOpticsVergencemedicineHumans0501 psychology and cognitive sciencesMaltese crossbusiness.industry05 social sciencesHealthy subjectsAccommodation OcularBiofeedback PsychologyRefractive ErrorsSensory SystemsOphthalmologyAberrations of the eyeSpherical aberration030221 ophthalmology & optometryFemalesense organsCuesbusinessPsychologyHigher-order aberrationsAccommodationVision Research
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Corrigendum to “Short-term changes in light distortion in orthokeratology subjects"

2015

Artigo completo publicado na revista "BioMed Research International, (2015), 1-7" e disponível no RepositóriUM em: http://hdl.handle.net/1822/33375

AdultMaleAdolescentLightmedicine.medical_treatmentVisual AcuityLentes de contactolcsh:MedicineBioinformaticsGeneral Biochemistry Genetics and Molecular BiologyContrast SensitivityCorneaYoung AdultDistortionMyopiamedicineHumansÓpticaScience & TechnologyGeneral Immunology and Microbiologybusiness.industrylcsh:ROrthokeratologyCorneal TopographyGeneral MedicineRefractive ErrorsTerm (time)OptometryFemaleCorrigendumbusinessOrthokeratologic Procedures
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Curvature of iris profile in spectral domain optical coherence tomography and dependency to refraction, age and pupil size - the MIPH Eye&Health …

2016

Purpose Optical coherence tomography (OCT) of the anterior segment allows quantitative analysis of the geometry of the iris. We performed spectral domain OCT examinations in healthy emmetropic, hyperopic and myopic subjects to investigate iris curvature and its associations. Methods In a cross-sectional study, out of 4617 eyes (2309 subjects) those with refractive errors of +3 dioptres were identified by objective refraction. The iris was examined using the anterior segment mode of a spectral domain 3D OCT-2000 (Topcon Inc., Japan) in the temporal meridian, and OCT scans were investigated with respect to presence and amount of convex and concave iris configuration. Ninety-three eyes of 50 s…

AdultMaleAdolescentgenetic structuresGonioscopyIrisEmmetropiaSpectral domainRefraction OcularCurvatureYoung Adult03 medical and health sciences0302 clinical medicineOptical coherence tomographyAnterior Eye SegmentGermanyEye healthHumansMedicineIntraocular PressureAgedmedicine.diagnostic_testbusiness.industryIncidenceAge FactorsPupil sizePupilGeneral MedicineMiddle AgedRefractive ErrorsRefractioneye diseasesOphthalmologyCross-Sectional StudiesMeridian (perimetry visual field)030221 ophthalmology & optometryOptometryFemalesense organsbusinessTomography Optical Coherence030217 neurology & neurosurgeryActa Ophthalmologica
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Repeatability assessment of biometric measurements with different refractive states and age using a swept-source biometer

2018

Background We aim to assess if refractive error or age may influence the repeatability of measurements using a swept-source biometer. Methods A total of 61 subjects were evaluated with IOLMaster 700 acquiring measurements of axial length (AL), central corneal thickness (CCT), white-to-white distance (WTW), anterior aqueous depth (AQD), lens thickness (LT), and keratometry (K) readings. Repeatability was evaluated classifying the sample according to the refractive state and age by the calculation of the within-subject standard deviation (Sw), coefficient of repeatability, and intraclass correlation coefficient. Results Very similar Sw was acquired among groups for AL, CCT, and WTW. Differenc…

AdultMaleAgingRefractive errormedicine.medical_specialtyBiometryIntraclass correlationBiomedical Engineering030204 cardiovascular system & hematologyAstigmatismStandard deviationlaw.inventionYoung Adult03 medical and health sciences0302 clinical medicineLens thicknessAge groupslawOphthalmologyLens CrystallinemedicineHumansMathematicsKeratometerAge FactorsReproducibility of ResultsGeneral MedicineRepeatabilityMiddle AgedRefractive Errorsmedicine.diseaseAxial Length EyeFemaleSurgeryTomography Optical Coherence030217 neurology & neurosurgeryExpert Review of Medical Devices
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Interchangeability among five devices that measure anterior eye distances.

2014

The aim was to study the interchangeability of various devices that measure anterior chamber depth (ACD) and white-to-white (WTW) distance.Eighty right eyes of eighty patients aged 20 to 40 years were included. Their spherical equivalent ranged from -4.25 to +1.00 dioptres. Each eye's ACD and the WTW distance were measured using the following devices: a Castroviejo surgical calliper, CA-200F Corneal Analyser, Orbscan II, Pentacam HR and IOLMaster 500.The Pentacam HR measured significantly greater ACD (p0.01) than the other two devices, whereas IOLMaster 500 and Orbscan II yielded comparable (p0.01) distances. Nonetheless, in every device comparison, the mean difference was within clinically…

AdultMaleBiometrybusiness.industryAnterior ChamberMeasure (physics)Corneal TopographyReproducibility of ResultsEquipment DesignRefraction OcularRefractive ErrorsInterchangeabilityCorneaOphthalmologyYoung AdultOpticsOptometryMedicineHumansFemaleProspective StudiesbusinessOptometryFollow-Up StudiesClinicalexperimental optometry
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