6533b820fe1ef96bd127a3fb

RESEARCH PRODUCT

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Nicholas G. MartinRené HöhnRené HöhnNagahisa YoshimuraJonathan H. LassIlkka SeppäläMasahiro MiyakeKay-tee KhawPirro G. HysiRhys FogartyYi LuZoran VatavukCécile DelcourtAndrew D. PatersonJohn P. KempJeremy A. GuggenheimJaakko KaprioJaakko KaprioRobert P. IgoJames F. WilsonStuart MacgregorAnthony P KhawajaBeate St PourcainMargaret M. DeangelisJing Hua ZhaoCornelia M. Van DuijnOlavi PärssinenTerho LehtimäkiRoger W. BeuermanLeslie J. RaffelEranga N. VithanaCaroline HaywardCathy WilliamsThomas MeitingerLei ZhouCandice E H HoOzren PolasekHoi Suen WongJie Jin WangNicholas J. TimpsonNorbert PfeifferToomas HallerAkira MeguroWei ChenChing-yu ChengChing-yu ChengVishal JhanjiJohannes R. VingerlingMika KähönenPuya GharahkhaniSheng FengNobuhisa MizukiMaurice YapKatie M. WilliamsVincent TanPaul MitchellTaina RantanenSudha K. IyengarSeang-mei SawChristopher J HammondKathryn P. BurdonHarry CampbellSarayut JanmahasatianAndres MetspaluCaroline C W KlaverJugnoo S RahiJugnoo S RahiKenji YamashiroLaura PortasCéline BellenguezIgor RudanRobert LubenVirginie J. M. VerhoevenMary Frances CotchPaul N. BairdQiao FanQiao FanNajaf AminDavid A. MackeyDavid A. MackeyJenifer E. HuffmanEmily Y. ChewVeluchamy A. BarathiTien Yin WongRonald KleinJeremy FondranMario PirastuAlan F. WrightJamie E CraigBrian W FleckPaul J. FosterAlvin L. YoungAlex W. HewittAlex W. HewittTin AungTin AungMaurizio FossarelloKari-matti MäkeläTanja ZellerMaria BlettnerXu WangEileen Tai-hui BohTerri L. YoungMingguang HeJoan E. Bailey WilsonOlli T. RaitakariShea Ping YipM. Kamran IkramM. Kamran IkramSeyhan YazarSeyhan YazarAlbert HofmanAlireza MirshahiTae Hwi Schwantes-anCharumathi SabanayagamCharumathi SabanayagamPancy O. S. TamGinevra BiinoXiaobo GuoAngela DöringAudrey Cougnard-gregoireDavid M. EvansDavid M. EvansXiaohui LiChristian GiegerSonghomitra Panda-jonasJost B. JonasJost B. JonasJan Willem L TidemanMaria SchacheChi Pui PangBarbara E.k. KleinSimona VaccargiuVeronique VitartJing XieClaire L. SimpsonS. Mohsen HosseiniChiea Chuen KhorChiea Chuen KhorChiea Chuen KhorDwight StambolianE. Shyong TaiXiangtian ZhouLi Jia ChenMilly S. TedjaMargaux A. MorrisonJanina S. RiedYik Ying TeoKonrad OexleRobert WojciechowskiRobert WojciechowskiNicholas J. WarehamAndré G. UitterlindenPeter K. JoshiYa Xing WangJean-françois KorobelnikJean-françois KorobelnikGeorge McmahonVinay NangiaElisabeth M. Van LeeuwenLindsay A. FarrerPreeti GuptaJohanna MazurEvelin MihailovWan’e. LimGeorge Davey SmithLiang XuRosalynn Grace SiantarRosalynn Grace SiantarJuho WedenojaCristina VenturiniCristina VenturiniFernando Rivadeneira

subject

0301 basic medicineRefractive errorgenetic structuresGeneral Physics and AstronomyGenome-wide association studyVARIANTSrefractive error ; geneEYEBioinformaticsINCIDENT MYOPIAGenome-wide association studiesSensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]0302 clinical medicinePolymorphism (computer science)10. No inequalityPOPULATIONeducation.field_of_studyMultidisciplinaryQACTIVATED PROTEIN-KINASEta3142single-nucleotide polymorphismRETINAL-PIGMENT EPITHELIUMOUTDOOR ACTIVITY3142 Public health care science environmental and occupational health3. Good healthRefractive errorsMeta-analysislociEducational StatusSciencePopulation610 Medicine & healthEnvironmentBiologyta3111Polymorphism Single NucleotideArticleWhite PeopleGeneral Biochemistry Genetics and Molecular BiologyEducation03 medical and health sciencesAsian PeopleSDG 3 - Good Health and Well-beingGenetic variationmedicineHumansSNPGenetic Predisposition to Diseasemyopia3125 Otorhinolaryngology ophthalmologyGenetic variationeducationRECEPTORGene Expression Profilingta1184General ChemistryHeritabilitymedicine.diseaseeye diseasesta3125TIME OUTDOORS030104 developmental biologyGenetic LociEvolutionary biologyRISK-FACTORS030221 ophthalmology & optometryREsense organs3111 BiomedicineGenome-Wide Association Study

description

Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10−5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

yearjournalcountryeditionlanguage
2016-04-06Nature Communications
10.1038/ncomms11008https://doi.org/10.1038/ncomms11008