Search results for "regeneration"
showing 10 items of 889 documents
Agrin in the Developing CNS: New Roles for a Synapse Organizer
2002
The heparan sulfate proteoglycan agrin is responsible for the formation, maintenance, and regeneration of the neuromuscular junction. In the central nervous system, agrin is widely expressed and concentrated at interneuronal synapses, but its function during synaptogenesis remains controversial. Instead, evidence for additional functions of agrin during axonal growth, establishment of the blood-brain barrier, and Alzheimer’s disease is accumulating.
Improved technique for stereotactic placement of nerve grafts between two locations inside the rat brain
2008
Peripheral nerve grafts have shown the ability to facilitate central axonal growth and regenerate the adult central nervous system. However, the detailed description of a technique for atraumatic graft placement within the brain is lacking. We present a stereotactic procedure to implant a peripheral nerve graft within a rat's brain with minimal brain tissue damage. The procedure permits a correct graft placement joining two chosen points, and the survival and integration of the graft in the host tissue with a light glial reaction, with evidence of central axonal growth inside the graft, at least up to 8 weeks after its implantation. (C) 2008 Elsevier B.V. All rights reserved.
Semaphorin 6A Improves Functional Recovery in Conjunction with Motor Training after Cerebral Ischemia
2010
Stroke is a major health problem in industrialized societies. Despite numerous attempts at developing acute stroke therapies aimed at minimizing acute infarct development, the only approved therapy so far is recombinant tissue plasminogen activator (rtPA). In recent years, the attention of the stroke community has therefore also put increased emphasis on understanding processes of post-stroke recovery, and their potential exploitability for therapeutic purposes. The brain has a remarkable ability to adapt to changes after stroke. Mechanisms that contribute to this plasticity are re-mapping and expansion of cortical areas to neighboring regions of functional motor cortex areas after injury […
Recovery of Bioactive Compounds from Marine Organisms: Focus on the Future Perspectives for Pharmacological, Biomedical and Regenerative Medicine App…
2023
Marine environments cover more than 70% of the Earth’s surface and are among the richest and most complex ecosystems. In terms of biodiversity, the ocean represents an important source, still not widely exploited, of bioactive products derived from species of bacteria, plants, and animals. However, global warming, in combination with multiple anthropogenic practices, represents a serious environmental problem that has led to an increase in gelatinous zooplankton, a phenomenon referred to as jellyfish bloom. In recent years, the idea of “sustainable development” has emerged as one of the essential elements of green-economy initiatives; therefore, the marine environment has been re-evaluated …
Protoplasts fromPodospora anserina: Isolation, purification, and transformation
1985
Protoplasts fromPodospora anserina mycelium were produced using the commercially available enzyme Novozym 234. Different parameters involved in protoplast isolation were analyzed in order to establish optimal conditions, and protoplast production was notably increased. For the purification of protoplasts, several techniques based on both centrifugation and filtration were assayed, with filtration yielding the best results. Regeneration of protoplasts was studied on different media and osmostic stabilizers, and about 80% regeneration was obtained. The good physiological condition of the protoplasts produced with this method is demonstrated by the lack of cell wall and high regeneration rate …
Genetic instability in calamondin (Citrus madurensis Lour.) plants derived from somatic embryogenesis induced by diphenylurea derivative
2007
Somatic embryos were regenerated in vitro from calamondin style-stigma explants cultured in the presence of N (6)-benzylaminopurine (BAP) cytokinin and three synthetic phenylurea derivatives, N-(2-chloro-4-pyridyl)-N-phenylurea (4-CPPU), N-phenyl-N'-benzothiazol-6-ylurea (PBU) and N,N'-bis-(2,3-methilendioxyphenyl)urea (2,3-MDPU). The phenylurea derivative compounds tested at micromolar level (12 muM) were able to induce a percentage of responsive explants significantly higher from that obtained with BAP and hormone-free (HF) conditions. In order to verify the genetic stability of the regenerants, 27 plants coming from different embryogenic events were randomly selected from each different …
Thermodynamic characterisation of novel solutions for closed-loop reverse electrodialysis
2018
Closed-loop reverse electrodialysis is a novel technology to convert low-grade heat directly into electricity. It consists of a reverse electrodialysis unit coupled with a regeneration unit in which the waste-heat is used to restore the initial conditions of the two solutions. One of the most impor- tant advantages of closed-loop system is the possibility to select an ad-hoc salt solution to obtain high efficiency. In this regard, it is important to assess how the salt solution properties affect the performance of the energy generation and solution regeneration processes. The aim of this study is to analyse the effect of thermodynamic properties of non-conventional salt solutions within a R…
Salinity gradient engines
2016
Abstract This chapter is devoted to the description of a new class of heat engines based on salinity gradient technology and able to convert low-grade heat into power. The salinity gradient power (SGP) process is employed within a closed loop composed of two different sections: (i) the SGP unit devoted to the energy production, and (ii) a regeneration unit fed by the solutions exiting from the SGP unit and able to restore the initial concentration, thus regenerating the salinity gradient. The main features, limits and perspectives of this novel heat engine are described along with an overview of the state of the art presented in the literature and an example of exergetic analysis of the cyc…
The Urban Landscape and the Real Estate Market. Structures and Fragments of the Axiological Tessitura in a Wide Urban Area of Palermo
2016
The proposed study deals with the urban landscape of Palermo and its possible representation from the perspective of the real estate market analysis. Real estate is one of the most significant types of capital asset and the wide range of its possible utilizations makes complex the interpretation of the market phenomena. The multi-layered reality of such a large city (represented through the sample of 500 properties) needs to be articulated into a significant set of sub-markets in order to outline the complexity and to map the distribution of homogeneous groups of properties within the whole city area. The comparison between quality and price within each cluster allows us to elicit the degre…
Plant facilitation and phylogenetics
2013
The relationship between facilitation and evolutionary ecology is poorly understood. We review five issues elucidating how the phylogenetic relatedness of species provides insight into the role of facilitation in community assembly: (a) Are the facilitative interactions more common between species that differ in a regeneration niche? (b) Are facilitative interactions more common between distantly related species? (c) Do communities governed by facilitation (rather than competition) have higher phylogenetic diversity? (d) As facilitated juvenile plants mature, do they compete with their nurses more often if they are closely related to them? (e) How does the phylogenetic signature in a commun…