Search results for "registries"

showing 10 items of 615 documents

Efficacy and safety of rituximab with and without methotrexate in the treatment of rheumatoid arthritis patients: Results from the GISEA register

2014

Abstract Introduction Rituximab (RTX) is a monoclonal anti-CD20 antibody approved for the treatment of rheumatoid arthritis (RA) in association with methotrexate (MTX). Objectives To evaluate the efficacy and safety of RTX–MTX combination therapy compared with RTX alone in the treatment of RA. Methods We analyzed data from a prospective cohort study, the Italian biologic register GISEA, to investigate the efficacy and safety of rituximab. Moreover, the adverse events (AE) and the causes of discontinuation therapy were analyzed. Results We identified 338 RA patients, 162 treated with RTX and 176 with RTX–MTX. After 52 and 104 weeks of therapy the disease activity score in 28 joints and the H…

RegistrieMaleanti-CD20 rituximab; rheumatoid arthritis; GISEArheumatoid arthritisSettore MED/16 - REUMATOLOGIAAnti-CD20Arthritis RheumatoidAntibodies Monoclonal Murine-DerivedRheumatoidMonoclonalRegistriesProspective cohort studyGISEAAnti-CD20; Methotrexate; Rheumatoid arthritis; Rituximab; Adult; Aged; Antibodies Monoclonal; Antibodies Monoclonal Murine-Derived; Antirheumatic Agents; Arthritis Rheumatoid; Drug Therapy Combination; Female; Humans; Male; Methotrexate; Middle Aged; Treatment Outcome; RegistriesAntirheumatic AgentAntibodies MonoclonalMiddle AgedTreatment OutcomeRituximab rheumatoid arthritisAntirheumatic AgentsRheumatoid arthritisCombinationMonoclonalDrug Therapy CombinationFemaleRituximabRituximabHumanmedicine.drugmusculoskeletal diseasesAdultMurine-Derivedmedicine.medical_specialtyCombination therapyAntibodiesNOAnti-CD20; Methotrexate; Rheumatoid arthritis; RituximabDrug TherapyRheumatologyanti-CD20 rituximabInternal medicinemedicineHumansRheumatoid arthritisAdverse effectRheumatoid arthritiAnti-CD20; Methotrexate; Rheumatoid arthritis; Rituximab; Adult; Aged; Antibodies Monoclonal; Antibodies Monoclonal Murine-Derived; Antirheumatic Agents; Arthritis Rheumatoid; Drug Therapy Combination; Female; Humans; Male; Methotrexate; Middle Aged; Rituximab; Treatment Outcome; Registries; RheumatologyAgedbusiness.industryArthritismedicine.diseaseSurgeryDiscontinuationMethotrexateMethotrexatebusinessJoint Bone Spine
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Hospital, local palliative care network and public health: how do they involve terminally ill patients?

2017

Background: Over one quarter of the health care expenditures is estimated to be spent for patients in the last year of life (LYL). For these patients, palliative care (PC) has been suggested as a response for improving the standards of care and reducing health costs. The aim of this study was to analyze a cohort of LYL people, in terms of comparing hospitalised patients who had been referred for PC to patients receiving usual care (UC). Methods: Retrospective study carried out on patients resident in Lecco (Italy) who died between 2012 and 2013. Records of patients were obtained from the Death certificate registry and cross-linked with Regional Healthcare Information System, Hospital Discha…

RegistrieMalemedicine.medical_specialtyPalliative careMEDLINETerminally illHospital03 medical and health sciencesPalliative Care Hospital Public Health costs0302 clinical medicineRetrospective StudieHealth caremedicineHumansTerminally Ill030212 general & internal medicineCommunity Health ServicesRegistriesCommunity Health ServiceAgedRetrospective StudiesAged 80 and overbusiness.industryPublic healthPalliative CarePublic Health Environmental and Occupational HealthRetrospective cohort studyHospitalsItaly030220 oncology & carcinogenesisEmergency medicineCohortFemaleDeath certificatePublic HealthHealth Services ResearchbusinessHumanEuropean journal of public health
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Collected World Experience About the Performance of the Snorkel/Chimney Endovascular Technique in the Treatment of Complex Aortic Pathologies

2015

OBJECTIVES: We sought to analyze the collected worldwide experience with use of snorkel/chimney endovascular aneurysm repair (EVAR) for complex abdominal aneurysm treatment. BACKGROUND: EVAR has largely replaced open surgery worldwide for anatomically suitable aortic aneurysms. Lack of availability of fenestrated and branched devices has encouraged an alternative strategy utilizing parallel or snorkel/chimney grafts (ch-EVAR). METHODS: Clinical and radiographic information was retrospectively reviewed and analyzed on 517 patients treated by ch-EVAR from 2008 from 2014 by prearranged defined and documented protocols. RESULTS: A total of 119 patients in US centers and 398 in European centers …

RegistrieMalemedicine.medical_treatmentKaplan-Meier EstimateGlobal HealthSettore MED/22 - Chirurgia VascolareSeverity of Illness IndexEndovascular aneurysm repairAortic aneurysmRetrospective StudieStentRegistriesAbdominal aortic aneurysm; Endovascular; Fenestrated; Thoracoabdominal; Vascular; Aortic Aneurysm Abdominal; Aortography; Blood Vessel Prosthesis Implantation; Endovascular Procedures; Europe; Female; Follow-Up Studies; Global Health; Humans; Kaplan-Meier Estimate; Male; Prosthesis Design; Prosthesis Failure; Retrospective Studies; Risk Assessment; Severity of Illness Index; Stents; Survival Rate; Treatment Outcome; United States; Blood Vessel Prosthesis; RegistriesEndovascularmedicine.diagnostic_testMedicine (all)Endovascular ProceduresAbdominal aortic aneurysmAortic AneurysmProsthesis FailureEuropeSurvival RateBlood Vessel ProsthesiTreatment OutcomeFemaleStentsHumanUnited Statemedicine.medical_specialtyAortographyProsthesis DesignAortographyRisk AssessmentFenestratedFollow-Up StudieBlood Vessel Prosthesis ImplantationBlood vessel prosthesisVascularmedicineHumansAbdominalSurvival rateRetrospective StudiesEndovascular Procedurebusiness.industryRetrospective cohort studymedicine.diseaseUnited StatesBlood Vessel ProsthesisSurgeryAbdominal aortic aneurysm; Endovascular; Fenestrated; Thoracoabdominal; Vascular; Aortic Aneurysm Abdominal; Aortography; Blood Vessel Prosthesis Implantation; Endovascular Procedures; Europe; Female; Follow-Up Studies; Global Health; Humans; Kaplan-Meier Estimate; Male; Prosthesis Design; Prosthesis Failure; Retrospective Studies; Risk Assessment; Severity of Illness Index; Stents; Survival Rate; Treatment Outcome; United States; Blood Vessel Prosthesis; Registries; Surgery; Medicine (all)Abdominal aortic aneurysmSurgeryThoracoabdominalbusinessAortic Aneurysm AbdominalFollow-Up StudiesAbdominal surgeryAnnals of Surgery
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Pattern of in-hospital changes in drug use in the older people from 2010 to 2016

2017

Purpose: To assess the pattern of in-hospital changes in drug use in older patients from 2010 to 2016. Methods: People aged 65 years or more acutely hospitalized in those internal medicine and geriatric wards that did continuously participate to the REgistro POliterapie Società Italiana di Medicina Interna register from 2010 to 2016 were selected. Drugs use were categorized as 0 to 1 drug (very low drug use), 2 to 4 drugs (low drug use), 5 to 9 drugs (polypharmacy), and 10 or more drugs (excessive polypharmacy). To assess whether or not prevalence of patients in relation to drug use distribution changed overtime, adjusted prevalence ratios (PRs) was estimated with log-binomial regression mo…

RegistrieMalepharmacoepidemiologyEpidemiologyDischarged alive030204 cardiovascular system & hematologyinternal medicine and geriatric warddrug use; excessive polypharmacy; internal medicine and geriatric wards; older people; pharmacoepidemiology; polypharmacyexcessive polypharmacyolder people0302 clinical medicineDrug PrescriptionRisk Factors80 and overPharmacology (medical)030212 general & internal medicineRegistriesAt-Risk Populationmedia_commonAged 80 and overOvertimedrug use excessive polypharmacy internal medicine and geriatric wards older people pharmacoepidemiology polypharmacyinternal medicine and geriatric wardsPharmacoepidemiologyHospitalizationItalyFemaleMedical emergencyHumanDrugmedicine.medical_specialtymedia_common.quotation_subjectSocio-culturaleDrug Prescriptions03 medical and health sciencesHospital dischargemedicineInternal MedicineHumanspolypharmacyAgeddrug usePolypharmacyInpatientsbusiness.industryRisk Factormedicine.diseasedrug use; excessive polypharmacy; internal medicine and geriatric wards; older people; pharmacoepidemiology; polypharmacy; Aged; Aged 80 and over; Drug Prescriptions; Female; Hospitalization; Humans; Internal Medicine; Italy; Male; Polypharmacy; Registries; Risk Factors; InpatientsEmergency medicinePolypharmacyOlder peoplebusiness
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Latent tubercolosis infection in patients with cronic plaque psoriasis: evidence from the Italian Psocare Registry

2015

SummaryBackground The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. Objectives To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. Methods Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. Results Latent tuberculosis infection was diagnosed in…

RegistrieMaletaiwanAntitubercular AgentsBiological Factorquantiferon-tb-goldAntitubercular AgentBiological FactorsexperienceResidence Characteristics80 and overPrevalenceRegistriesYoung adultriskAged 80 and overLatent TuberculosiLatent tuberculosispsoriasisMiddle AgedItalyFemaletubercolosistubercolosiAdolescent; Adult; Age Distribution; Aged; Aged 80 and over; Antitubercular Agents; Biological Factors; Chronic Disease; Female; Humans; Italy; Latent Tuberculosis; Male; Middle Aged; PUVA Therapy; Prevalence; Psoriasis; Registries; Residence Characteristics; Sex Distribution; Tuberculin Test; Young Adult; 2708Humanmedicine.drugAdultmedicine.medical_specialtyAdolescentchronic plaque psoriasisTuberculinconsensus statementtubercolosis; psoriasisDermatology.Young Adulttuberculosis infectionSettore MED/35Age DistributionLatent TuberculosisInternal medicinePsoriasismedicineAdalimumabfactor antagonistsHumansPsoriasisnecrosis-factor blockers; quantiferon-tb-gold; consensus statement; factor antagonists; systemic treatment; therapy; experience;taiwan; assay; risknecrosis-factor blockersSex DistributionAdolescent; Adult; Age Distribution; Aged; Aged 80 and over; Antitubercular Agents; Biological Factors; Chronic Disease; Female; Humans; Italy; Latent Tuberculosis; Male; Middle Aged; PUVA Therapy; Prevalence; Psoriasis; Registries; Residence Characteristics; Sex Distribution; Tuberculin Test; Young AdultPUVA TherapyAgedPsoriasiHistory of tuberculosistherapytuberculosis infection chronic plaque psoriasisItalian Psocare Registrybusiness.industryTuberculin TestOdds ratiosystemic treatmentassaymedicine.diseasebacterial infections and mycosesConfidence intervalSurgeryResidence CharacteristicChronic DiseaseItalian Psocare Registrybusiness2708
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Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Resear…

2021

Abstract Background Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients’ clinical phenotypes and analyse the differential clinical course. Methods We performed a hierarchical cluster analysis based on Ward’s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results A total of 9363 were available for this analysis. We identified three …

RegistrieResearch Reportmedicine.medical_specialtyMajor adverse outcomeCardiovascular risk factorsCluster analysisRisk FactorsInternal medicineClinical phenotypeAtrial FibrillationEpidemiologyHumansMedicineRegistriesCluster analysiAtrial fibrillation; Clinical management; Clinical phenotypes; Cluster analysis; Major adverse outcomes; Humans; Phenotype; Registries; Research Report; Risk Factors; Atrial FibrillationClinical managementbusiness.industryProportional hazards modelRisk FactorHazard ratioRAtrial fibrillationClinical phenotypesMajor adverse outcomesGeneral Medicinemedicine.diseaseAtrial fibrillationConfidence intervalPhenotypeCohortMedicineObservational studybusinessResearch ArticleHumanBMC Medicine
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Prophylaxis in congenital factor VII deficiency: indications, efficacy and safety. Results from the Seven Treatment Evaluation Registry (STER)

2013

WOS: 000319897700018

RegistrieSevere bleedingAdultMalePediatricsmedicine.medical_specialtyTime FactorsTime FactorAdolescentFactor VII DeficiencyPROPHYLAXIS FACTOR VII DEFICIENCYFactor VIIachemistry.chemical_compoundPlasmaYoung AdultMedicineHumansRegistriesYoung adultFactor VII deficiencyChildFactor VIIbusiness.industryInfantHematologyRecombinant ProteinFactor VIIMiddle Agedmedicine.diseaseThrombosisRecombinant ProteinsClinical trialTreatment OutcomechemistryTreatment evaluationWeekly doseChild PreschoolFemaleOriginal Articles and Brief ReportsbusinessHuman
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Soft tissue sarcoma in Italy: From epidemiological data to clinical networking to improve patient care and outcomes

2019

Sarcomas are rare malignant neoplasms that develop from mesenchymal cells and include a heterogeneous and large group of histological subtypes that may occur at any anatomical site. Soft tissue sarcomas (STS), the focus of this review, account for ≈70‒80% of sarcomas and represent <1% of all cancers. The heterogeneity of STS applies to both their topography and morphology, and 5-year survival can vary widely depending on disease stage and the complex interplay between anatomical site and histology for different STS subtypes. The rarity and heterogeneity of STS, together with other factors, such as the lack of clinical expertise often lead to difficulties and delays in making an accurate …

Registriemedicine.medical_specialtyCancer ResearchHistologyEpidemiologyCancer registrieSoft Tissue NeoplasmsDiseaseEuropean reference networkPatient careClinical expertise03 medical and health sciences0302 clinical medicineEpidemiologymedicinePrevalenceHumansCancer registriesRegistries030212 general & internal medicineStage (cooking)Intensive care medicineSoft tissue sarcomaReference centresbusiness.industrySoft tissue sarcomaCancer registries; Epidemiology; European reference network; Histology; Incidence; Italian rare cancer network; Prevalence; Reference centres; Regional variability; Soft tissue sarcoma; Epidemiology; Oncology; Cancer ResearchIncidenceReference centreCancerSarcomaRegional variabilitymedicine.diseaseItalyOncology030220 oncology & carcinogenesisItalian rare cancer networkPatient CarebusinessLarge groupHuman
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The Challenges of the European Anorectal Malformations-Net Registry

2015

Item does not contain fulltext Anorectal malformations (ARM) have a low prevalence, patients need specialized surgical care, and in many cases, patients born with ARM even need life-long aftercare. Due to its low prevalence most patients are still treated in low-volume pediatric surgical centers without any adequate monitoring of the outcome. Data on prevalence, comparison of different surgical techniques, and prospective outcome measurements are still scarce and difficult to interpret. In 2010, a consortium was founded (ARM-Net consortium) including several European pediatric surgical centers to collaborate more in research and share knowledge on ARM. One of the structures started by the c…

Registrymedicine.medical_specialtyPediatricsOutcome measurementsbusiness.industryGeneral surgerySurgical careRectumAnal CanalNetworkAnorectal malformationAnorectal MalformationsRare diseasesAnorectal malformation; Network; Rare diseases; RegistryReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]Anus ImperforateEuropeReconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10]Pediatrics Perinatology and Child HealthStill facemedicineHumansSurgeryRegistriesbusinessEuropean Journal of Pediatric Surgery
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A cardiovascular educational intervention for primary care professionals in Spain: positive impact in a quasi-experimental study

2015

Background Routine general practice data collection can help identify patients at risk of cardiovascular disease. Aim To determine whether a training programme for primary care professionals improves the recording of cardiovascular disease risk factors in electronic health records. Design and setting A quasi-experimental study without random assignment of professionals. This was an educational intervention study, consisting of an online-classroom 1-year training programme, and carried out in the Valencian community in Spain. Method The prevalence rates of recording of cardiovascular factors (recorded every 6 months over a 4-year period) were compared between intervention and control group. …

Relative risk reductionMalePediatricsmedicine.medical_specialtyEducation ContinuingInservice TrainingCardiologyRisk AssessmentDiabetes mellitushealth educationMedicineElectronic Health RecordsHumansprevention and controlPrimary Health Carebusiness.industryRandom assignmentResearchAbsolute risk reductionregistriesMiddle Agedmedicine.diseaseQuality ImprovementConfidence intervalcardiovascular diseasesBlood pressureBasal (medicine)Cardiovascular DiseasesSpainFemaleEducational MeasurementFamily PracticeRisk assessmentbusiness
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