Search results for "signe"
showing 10 items of 145 documents
Influence of CYP2D6 polymorphism on the cytotoxicity of the designer drug 4-methylthioamphetamine (4-MTA)
2007
Strongly invertible links and divides
2008
Abstract To a proper generic immersion of a finite number of copies of the unit interval in a 2-disc, called a divide, A’Campo associates a link in S 3 . From the more general notion of ordered Morse signed divides, one obtains a braid presentation of links of divides. In this paper, we prove that every strongly invertible link is isotopic to the link of an ordered Morse signed divide. We give fundamental moves for ordered Morse signed divides and show that strongly invertible links are equivalent if and only if we can pass from one ordered Morse signed divide to the other by a sequence of such moves. Then we associate a polynomial to an ordered Morse signed divide, invariant for these move…
On a representation theorem for finitely exchangeable random vectors
2016
A random vector $X=(X_1,\ldots,X_n)$ with the $X_i$ taking values in an arbitrary measurable space $(S, \mathscr{S})$ is exchangeable if its law is the same as that of $(X_{\sigma(1)}, \ldots, X_{\sigma(n)})$ for any permutation $\sigma$. We give an alternative and shorter proof of the representation result (Jaynes \cite{Jay86} and Kerns and Sz\'ekely \cite{KS06}) stating that the law of $X$ is a mixture of product probability measures with respect to a signed mixing measure. The result is "finitistic" in nature meaning that it is a matter of linear algebra for finite $S$. The passing from finite $S$ to an arbitrary one may pose some measure-theoretic difficulties which are avoided by our p…
Simultaneous determination of traditional and emerging illicit drugs in sediments, sludges and particulate matter
2015
An analytical method for determining traditional and emerging drugs of abuse in particulate matter, sewage sludge and sediment has been developed and validated. A total of 41 drugs of abuse and metabolites including cocainics, tryptamines, amphetamines, arylcyclohexylamines, cathinones, morphine derivatives, pyrrolidifenones derivatives, entactogens, piperazines and other psychostimulants were selected. Samples were ultrasound extracted with McIlvaine buffer and methanol, and the extracts were cleaned up by solid phase extraction (SPE) using Strata-X cartridges. Drugs were eluted using methanol and methanol-dichloromethane and determined by liquid chromatography tandem mass spectrometry. Th…
A multicriteria extension of the efficient market hypothesis
2021
Challenging the Efficient Market Hypothesis (EMH) has been a recurrent topic for researchers and practitioners since its formulation. Hundreds of empirical studies claim to either prove or disprove the EMH by means of a number of heterogeneous methods. Even though the EMH is usually adjusted to a measure of risk, there is a lack of a formal analysis within a multiple-criteria context. In this paper, we propose a extension of the EMH that accommodates the foundations of multiple-criteria decision analysis. To this end, we rely on a family of parametric signed dissimilarity measures to assess multidimensional performance differences. Since normalization is a critical step in our approach to a…
Many languages, many modalities : Finnish Sign Language signers as learners of English
2015
For a multilingual person, language learning is a process which requires and makes use of many varied characteristics that have developed in multilingual environments. This study deals with the learner beliefs of Finnish Sign Language (FinSL) signers who study at the university. The data for this study consist of student interviews and essays collected in connection with an English course at the Language Centre. In this article, we focus on discussing how the linguistic background and learner beliefs of FinSL signers form a basis for exploring features that affect their learning of English. Based on the socio-cultural framework, the learner beliefs these students have formed have been exami…
Ernesto Basile: dal progetto integrale al disegno industriale
2020
The design in the various sectors of decorative and industrial arts for Ernesto Basile represents a unitary fact linked to architectural composition. His activity in the different artistic sectors stands out above all for his ability to identify autonomous fields of research and experimentation. The truly innovative scope of Basile’s role lies above all in his being probably the only Italian architect of international level consciously devoted to the principle of integral design and to an effective leveling of the arts. This will lead him in the arc of his entire activity, from the integral project to industrial design, to anticipate the birth of the figure of the designer.
CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA)
2006
4-Methylthioamphetamine (4-MTA) belongs to a group of new amphetamine derivatives that is usually sold as "ecstasy" or "flatliners" on the illicit drug market. Large interindividual differences in 4-MTA mediated toxicity have been reported in humans. Therefore, we tested whether CYP2D6 or its variant alleles as well as CYP3A4 influence the susceptibility to 4-MTA. For this purpose, we used the colony formation assay with Chinese hamster lung fibroblast V79 cells expressing human wild-type CYP2D6 (CYP2D6*1), the low activity alleles CYP2D6*2, CYP2D6*9, as well as human CYP3A4. The obtained results showed that the expression of wild type CYP2D6*1 clearly enhanced the susceptibility to the cyt…
Challenging management of gingival squamous cell carcinoma: a 10 years single-center retrospective study on Northern-Italian patients.
2020
Background Aim of this study was to describe the outcome of patients with gingival squamous cell carcinoma (GSCC), and to recognize aspects affecting clinical course and to consider survival rate. Material and Methods The case records of patients, over a 10-year period, were retrospectively examined. Differences in distribution of the potential risk factors by prognosis were investigated through non-parametrical tests (Wilcoxon Rank-Sum and Fisher’s Exact). Survival curves for age, therapy and stage were built by the Kaplan-Meier method and compared with Log-Rank test. Results 79 patients were analysed. Significant increase in mortality for patients older than 77 and for those with advanced…
G-quadruplex recognition by DARPIns through epitope/paratope analogy
2022
AbstractWe investigated the mechanisms leading to the specific recognition of Guanine Guadruplex (G4) by DARPins peptides, which can lead to the design of G4s specific sensors. To this end we carried out all-atom molecular dynamic simulations to unravel the interactions between specific nucleic acids, including human-telomeric (h-telo), Bcl-2, and c-Myc, with different peptides, forming a DARPin/G4 complex. By comparing the sequences of DARPin with that of a peptide known for its high affinity for c-Myc, we show that the recognition cannot be ascribed to sequence similarity but, instead, depends on the complementarity between the three-dimensional arrangement of the molecular fragments invo…