Search results for "significance"
showing 10 items of 532 documents
Application of the Morris method for screening the influential parameters of fuzzy controllers applied to wastewater treatment plants
2011
In this paper,we evaluate the application of a sensitivity analysis to help fine-tuning a fuzzy controller for a biological nitrogen and phosphorus removal (BNPR) plant. TheMorris Screeningmethod is proposed and evaluated as a prior step to obtain the parameter significance ranking. First, an iterative procedure has been performed in order to find out the proper repetition number of the elementary effects (r) of the method. The optimal repetition number found in this study (r = 60) is in direct contrast to previous applications of the Morris method, which usually use low repetition number, e.g. r = 10 ~ 20. Working with a non-proper repetition number (r) could lead to Type I error (identify…
Internal Quality Assurance for Higher Education Study Programme
2015
<p>Quality assurance for study programme is necessary precondition to realize qualitative higher education. Quality assessment is important part of quality assurance cycle. There are used different methodologies, assessment criteria and indicators to assess the higher education quality. It is clear that the assessment results which study programme will be better or worse are detected by the choice of criteria. It is difficult to find objective criteria which could be used universally for all study programme types. The aim of the research is to investigate quality assurance cycle for study programme quality and pay main attention to assessment part. The aim of assessment part is to sel…
90Y radioembolization in the treatment of neuroendocrine neoplasms: Results of an international multicenter retrospective study.
2021
In neuroendocrine neoplasms (NEN), the presence of distant metastases has a severe impact on survival leading to a relevant decrease of the 5-year survival rate. Here, 90Y radioembolization (RE) might be an important treatment option, however, data to support clinical benefits for RE are scarce. Therefore, the purpose of this study was to analyze the use of RE in NEN patients with hepatic metastases in an international, multi-center retrospective analysis and assess the potential role of RE in a multimodal treatment concept. Methods: 297 angiographic evaluations in NEN patients prior to RE were analyzed. Baseline characteristics and parameters derived from imaging evaluation and RE were ana…
Comparison between whole blood viscosity measured and calculated in subjects with monoclonal gammopathy of undetermined significance and in patients …
2021
BACKGROUND: in this study, with a re-evaluation of the hemorheological determinants previously described in MGUS subjects and in MM patients, we have detected the calculated whole blood viscosity, according whether to the hematocrit and total plasma protein concentration (de Simone formula) or to the haematocrit and plasma fibrinogen level (Merrill formula), and a marker of the erythrocyte aggregation (albumin/fibrinogen level). METHODS: data were expressed as means±standard deviation. Student’s t test for unpaired data was used to compare MGUS subjects and MM patients. The correlation coefficient between mean erythrocyte aggregation (MEA) and hematocrit (Ht) was evaluated in MGUS, MM and M…
Infant mortality gap in the Baltic region - Latvia, Estonia, and Lithuania - in relation to macroeconomic factors in 1996-2010.
2013
Background and Objective. A constant gap has appeared in infant mortality among the 3 Baltic States - Latvia, Estonia, and Lithuania – since the restoration of independence in 1991. The aim of the study was to compare infant mortality rates in all the 3 Baltic countries and examine some of the macro- and socioeconomic factors associated with infant mortality. Material and Methods. The data were obtained from international databases, such as World Health Organization and EUROSTAT, and the national statistical databases of the Baltic States. The time series data sets (1996–2010) were used in the regression and correlation analysis. Results. In all the 3 Baltic States, a strong and significant…
Corrigendum: ExGUtils: A Python Package for Statistical Analysis With the ex-Gaussian Probability Density
2018
The study of reaction times and their underlying cognitive processes is an important field in Psychology. Reaction times are usually modeled through the ex-Gaussian distribution, because it provides a good fit to multiple empirical data. The complexity of this distribution makes the use of computational tools an essential element in the field. Therefore, there is a strong need for efficient and versatile computational tools for the research in this area. In this manuscript we discuss some mathematical details of the ex-Gaussian distribution and apply the ExGUtils package, a set of functions and numerical tools, programmed for python, developed for numerical analysis of data involving the ex…
Falacias sobre el valor p compartidas por profesores y estudiantes universitarios
2017
Resumen La “Práctica Basada en la Evidencia” exige que los profesionales valoren de forma crítica los resultados de las investigaciones psicológicas. Sin embargo, las interpretaciones incorrectas de los valores p de probabilidad son abundantes y repetitivas. Estas interpretaciones incorrectas afectan a las decisiones profesionales y ponen en riesgo la calidad de las intervenciones y la acumulación de un conocimiento científico válido. Identificar el tipo de falacia que subyace a las decisiones estadísticas es fundamental para abordar y planificar estrategias de educación estadística dirigidas a intervenir sobre las interpretaciones incorrectas. En consecuencia, el objetivo de este estudio e…
Functional Significance of Microsatellite Markers
2014
The review summarizes literature data on the positive results of association studies between the length of microsatellite repeats and predisposition to pathologies. Actually, the data can be classified according to the localization of the microsatellite: in the gene promoter, in the part of exon 1 coding the signal sequence, in gene introns, in the coding areas of genes, and in 3'-untranslated regions. The functional significance of microsatellite length changes can be evaluated in many cases. The authors came up to the conclusion that further studies on microsatellite associations with diseases remain prospective as they reflect changes in the gene functional activity.
Clinical relevance of polymorphic markers of arterial thrombosis.
1997
Case-control and cross-sectional studies show that some common molecular variations (polymorphisms) of genes coding for proteins involved in atherosclerosis and thrombosis are often present in subjects who have experienced cerebrovascular or cardiovascular events. The clinical impact of the majority of polymorphic markers is disputed by prospective reports. In contrast, their pathophysiological implications and their role in monitoring parameters that are difficult to be checked by alternative means, are documented by the large majority of the reports. From the evidence available, there may be suggestion for further impact of polymorphic markers in vascular medicine. To substantiate this, n…
The Clinical Significance of Unknown Sequence Variants in BRCA Genes.
2010
Abstract: Germline mutations in BRCA1/2 genes are responsible for a large proportion of hereditary breast and/or ovarian cancers. Many highly penetrant predisposition alleles have been identified and include frameshift or nonsense mutations that lead to the translation of a truncated protein. Other alleles contain missense mutations, which result in amino acid substitution and intronic variants with splicing effect. The discovery of variants of uncertain/unclassified significance (VUS) is a result that can complicate rather than improve the risk assessment process. VUSs are mainly missense mutations, but also include a number of intronic variants and in-frame deletions and insertions. Over …