Search results for "silica"

showing 10 items of 1092 documents

Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells

2015

In recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming common issues such as poor water solubility and poor stability of some drugs. In particular, redox-responsive delivery systems have attracted the attention of scientists because of the intracellular reductive environment related to a high concentration of glutathione (GSH). In this context, we describe herein the development of a GSH-responsive delivery system based on poly(ethylene glycol)- (PEG-)…

INGENIERIA DE LA CONSTRUCCIONCell SurvivalIntracellular SpaceNanoparticleNanotechnologyAntineoplastic AgentsCONTROLLED-RELEASETRIGGERED RELEASEPolyethylene Glycolschemistry.chemical_compoundINORGANIC NANOPARTICLESQUIMICA ORGANICASYSTEMSPEG ratioQUIMICA ANALITICAElectrochemistrymedicinePOLYMER HYBRID NANOPARTICLESGLUTATHIONEBIOQUIMICA Y BIOLOGIA MOLECULARHumansGeneral Materials ScienceDoxorubicinSpectroscopyDrug CarriersENHANCED PERMEABILITYQUIMICA INORGANICASurfaces and InterfacesGlutathioneIN-VITROMesoporous silicaCondensed Matter PhysicsSilicon DioxideControlled releaseGUEST MOLECULESBioavailabilityDrug LiberationchemistryDoxorubicinDelayed-Action PreparationsDrug DesignNanoparticlesPhenazinesSUPPORTSEthylene glycolOxidation-ReductionPorositymedicine.drugHeLa Cells
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Cathepsin-B Induced Controlled Release from Peptide-Capped Mesoporous Silica Nanoparticles

2014

New capped silica mesoporous nanoparticles for intracellular controlled cargo release within cathepsin B expressing cells are described. Nanometric mesoporous MCM-41 supports loaded with safranin O (S1-P) or doxorubicin (S2-P) containing a molecular gate based on a cathepsin B target peptidic sequence were synthesized. Solids were designed to show "zero delivery" and to display cargo release in the presence of cathepsin B enzyme, which selectively hydrolyzed in vitro the capping peptide sequence. Controlled delivery in HeLa, MEFs WT, and MEFs lacking cathepsin B cell lines were also tested. Release of safranin O and doxorubicin in these cells took place when cathepsin B was active or presen…

INGENIERIA DE LA CONSTRUCCIONCell Survivalgated mesoporous materialsPeptideAntineoplastic AgentsCatalysisCathepsin BCell LineCathepsin BHeLaQUIMICA ORGANICAHumansCytotoxicityPeptide sequencechemistry.chemical_classificationDrug CarriersbiologyOrganic ChemistryQUIMICA INORGANICAGeneral ChemistryMesoporous silicabiology.organism_classificationSilicon DioxideControlled releasechemistryBiochemistryDoxorubicinBiophysicspeptidesnanoparticlescontrolled releasePorosityIntracellularHeLa Cells
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Glucose-triggered release using enzyme-gated mesoporous silica nanoparticles.

2013

[EN] A new gated nanodevice design able to control cargo delivery using glucose as a trigger and cyclodextrin-modified glucose oxidase as a capping agent is reported.

INGENIERIA DE LA CONSTRUCCIONDelivery SystemGuest moleculesSupportsSilicon dioxideCarbon nanotubesResponsive controlled releaseNanoparticleNanotechnologyCatalysischemistry.chemical_compoundGlucose OxidaseQUIMICA ORGANICAQUIMICA ANALITICAMaterials ChemistryOrganometallic CompoundsTriggered releaseGlucose oxidaseHydrogen peroxideColoring AgentsNanodevicechemistry.chemical_classificationbiologyQUIMICA INORGANICAMetals and AlloysGeneral ChemistryMesoporous silicaHydrogen peroxideSilicon DioxideSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsEnzymeGlucosechemistryCeramics and Compositesbiology.proteinBiophysicsNanoparticlesPorosityChemical communications (Cambridge, England)
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Modulation of folic acid bioaccessibility by encapsulation in pH-responsive gated mesoporous silica particles

2015

[EN] A study on the controlled release of folic acid (FA) from pH-responsive gated mesoporous silica particles (MSP) is reported. The MCM-41 support was synthesized using tetraethyl orthosilicate (TEOS) as hydrolytic inorganic precursor and the surfactant hexadecyltrimethylammonium bromide (CTAB) as porogen species. Calcination of the mesostructured phase resulted in the starting solid. This solid was loaded with FA to obtain the initial support S0. Moreover, this FA-loaded material was further functionalized with 3-[2-(2-aminoethylamino)ethylamino]propyltrimethoxysilane (N3) in order to obtain the gated polyamine-functionalised material S1. Solids S0 and S1 were characterized using standar…

INGENIERIA DE LA CONSTRUCCIONFolic acidTECNOLOGIA DE ALIMENTOSBioaccessibilityMesoporous silica particleslaw.inventionchemistry.chemical_compoundHydrolysisQUIMICA ORGANICAPulmonary surfactantlawControlled releaseGeneral Materials ScienceCalcinationLoading optimizationChromatographyChemistryQUIMICA INORGANICAGeneral ChemistryMesoporous silicaCondensed Matter PhysicsControlled releaseTetraethyl orthosilicateMechanics of MaterialsSurface modificationMesoporous materialNuclear chemistry
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Protective effect of mesoporous silica particles on encapsulated folates.

2016

Mesoporous silica particles (MSPs) are considered suitable supports to design gated materials for the encapsulation of bioactive molecules. Folates are essential micronutrients which are sensitive to external agents that provoke nutritional deficiencies. Folates encapsulation in MSPs to prevent degradation and to allow their controlled delivery is a promising strategy. Nevertheless, no information exists about the protective effect of MSPs encapsulation to prevent their degradation. In this work, 5-formyltetrahydrofolate (FO) and folic acid (FA) were entrapped in MSPs functionalized with polyamines, which acted as pH-dependent molecular gates. The stability of free and entrapped vitamins af…

INGENIERIA DE LA CONSTRUCCIONFolic acidTECNOLOGIA DE ALIMENTOSLightSilicon dioxideBioactive moleculesPharmaceutical Science02 engineering and technology010402 general chemistry01 natural sciencesMesoporous silica particleschemistry.chemical_compoundFolic AcidMicroscopy Electron TransmissionControlled deliveryControlled releasechemistry.chemical_classificationChromatographyBiomoleculeQUIMICA INORGANICATemperatureGeneral Medicine5-FormyltetrahydrofolateMesoporous silicaHydrogen-Ion Concentration021001 nanoscience & nanotechnologySilicon DioxideControlled release0104 chemical sciencesBioavailabilitychemistryFolic acidChemical engineeringMicroscopy Electron ScanningEncapsulation0210 nano-technologyStabilityPorosityPowder DiffractionBiotechnologyEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
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Hydrolysis of DCNP (a Tabun mimic) catalyzed by mesoporous silica nanoparticles

2015

[EN] The hydrolysis of diethylcyanophosphonate, DCNP (a Tabun simulant) in the presence of mesoporous silica nanoparticles (MSN) has been studied in acetonitrile:water (99.5:0.5 v/v) mixtures using 31P NMR as a suitable technique to follow the DCNP hydrolysis. MSN alone was not capable to induce DCNP hydrolysis, yet MSN in combination with the presence of the bases potassium carbonate, triethylamine or DABCO enhanced DCNP degradation. When MSN was used combined with K2CO3, a hydrolysis of ca. 95% of the initial DCNP after 60 min was observed. In the presence of DABCO, MSN was able to induce the hydrolysis of ca. 90% of DCNP after the same time. However, the DCNP hydrolysis using MSN in the …

INGENIERIA DE LA CONSTRUCCIONHydrolysisQUIMICA INORGANICAGeneral ChemistryDABCOMesoporous silicaCondensed Matter PhysicsCatalysisPotassium carbonatechemistry.chemical_compoundHydrolysisQUIMICA ORGANICAchemistryMechanics of MaterialsNerve agent simulantsOrganic chemistryNanoparticlesGeneral Materials ScienceAcetonitrilePhosphoric acidTriethylamineMesoporous silicaTabunNuclear chemistry
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Enhanced antifungal efficacy of tebuconazole using gated pH-driven mesoporous nanoparticles

2014

Núria Mas,1–3 Irene Galiana,3 Silvia Hurtado,† Laura Mondragón,1–3 Andrea Bernardos,1–3 Félix Sancenón,1–3 María D Marcos,1–3 Pedro Amorós,4 Nuria Abril-Utrillas,5 Ramón Martínez-Máñez,1–3 José Ramón Murguía1,3 1Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Valencia, Spain; 2Departamento de Química, Universidad Politécnica de Valencia, Valenci…

INGENIERIA DE LA CONSTRUCCIONMaterials scienceAntifungal AgentsPH-responsive nanoparticlesCell Survivalmedia_common.quotation_subjectCapped mesoporous nanoparticlesBiophysicsPharmaceutical ScienceNanoparticleBioengineeringSaccharomyces cerevisiaeNanocapsulesBiomaterialsDiffusionchemistry.chemical_compoundNanoporesQUIMICA ORGANICANanocapsulesInternational Journal of NanomedicineDrug DiscoveryQUIMICA ANALITICABIOQUIMICA Y BIOLOGIA MOLECULARFluoresceinParticle SizeCytotoxicityInternalizationmedia_commonTebuconazoleOriginal ResearchIntracellular releaseOrganic ChemistryQUIMICA INORGANICADrug SynergismGeneral MedicineMesoporous silicaHydrogen-Ion ConcentrationTriazoleschemistryBiochemistryDelayed-Action PreparationsBiophysicsTebuconazole loadingMesoporous materialPorosityInternational Journal of Nanomedicine
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Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles

2012

MCM-41 silica nanoparticles were used as inorganic scaffolding to prepare a nanoscopic-capped hybrid material S1, which was able to release an entrapped cargo in the presence of certain enzymes, whereas in the absence of enzymes, a zero release system was obtained. S1 was prepared by loading nanoparticles with Safranine O dye and was then capped with a gluconamide derivative. In the absence of enzymes, the release of the dye from the aqueous suspensions of S1 was inhibited as a result of the steric hindrance imposed by the bulky gluconamide derivative, the polymerized gluconamide layer and the formation of a dense hydrogen-bonded network around the pore outlets. Upon the addition of amidase…

INGENIERIA DE LA CONSTRUCCIONMaterials scienceCell SurvivalNanoparticleAntineoplastic AgentsElectron Microscopy Service of the UPVGluconatesAmidaseAmidohydrolasesHydrolysisQUIMICA ORGANICAEnzymatic hydrolysisPeptide bondOrganic chemistryHumansGeneral Materials ScienceDrug effectsMicroscopy ConfocalQUIMICA INORGANICAHydrogen BondingMesoporous silicaSilicon DioxideControlled releaseCombinatorial chemistryMCF-7 CellsNanoparticlesCamptothecinHybrid materialLysosomesPorosityHeLa Cells
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Tetrathiafulvalene-Capped Hybrid Materials for the Optical Detection of Explosives

2013

[EN] Mesoporous silica microparticles capped with TTF moieties and containing a ruthenium dye in the pores were used for the turn-on optical detection of the nitroaromatic explosives Tetryl and TNT via a selective pore uncapping and release of the entrapped dye.

INGENIERIA DE LA CONSTRUCCIONMaterials scienceExplosive materialInorganic chemistrychemistry.chemical_elementChemistry Techniques AnalyticalNitroaromatic explosivesMolecular Gateschemistry.chemical_compoundQUIMICA ORGANICANitroaromatic explosivesExplosive AgentsHeterocyclic CompoundsQUIMICA ANALITICAControlled releaseGeneral Materials ScienceChemosensorsQUIMICA INORGANICAMesoporous solidsMesoporous silicaSilicon DioxideTetrylControlled releaseRutheniumchemistryTetrathiafulvaleneHybrid materialPorosityTetrathiafulvaleneTrinitrotolueneACS Applied Materials & Interfaces
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Ceramic foam supported active materials for boron remediation in water

2015

Due to the narrowrange between boron necessities and toxicity in the environment, there is a high interest in the design of effective boron remediation procedures. We have previously reported a promising boron adsorptionmaterial based on the affinity of boron aqueous species for cis-diol groups that were anchored on differentmesoporous silica matrices.However, the small particle size of these systemsmakes themdifficult to be applied on real remediation situations. In this context we report herein a novel systemfor boron adsorption fromaqueous solutions inwhich the high boron affinity for functionalized mesoporousmaterials is combined with themechanical properties of ceramic foams as macrosc…

INGENIERIA DE LA CONSTRUCCIONMaterials scienceGeneral Chemical Engineeringchemistry.chemical_elementContext (language use)QUIMICA ORGANICAAdsorptionGeneral Materials ScienceCeramicBoronWater Science and TechnologyFunctionalized mesoporous adsorbentsCeramic foamAqueous solutionMechanical EngineeringQUIMICA INORGANICACeramic monoliths supported mesoporous adsorbentsGeneral ChemistryMesoporous silicaCeramic monoliths as supporting matricesBoron remediationchemistryChemical engineeringvisual_artvisual_art.visual_art_mediumMesoporous materialDesalination
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