Search results for "soin"
showing 10 items of 600 documents
Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lym…
2022
Lymphomas are among the ten most common cancers, and, although progress has been achieved in increasing survival, there is still an unmet need for more effective therapeutic approaches, including better options for patients with refractory tumors that initially respond but then relapse. The lack of effective alternative treatment options highlights the need to develop new therapeutic strategies capable of improving survival prospects for lymphoma patients. Herein, we describe the identification and exploration of the SAR of a series of [1,2]oxazolo[5,4-e]isoindoles as potent small molecules that bind to the colchicine site of tubulin and that have promise for the treatment of refractory lym…
Synthesis of 2H-Imidazo[2',1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myelo…
2022
Despite progressive advances in understanding the molecular biology of acute myeloid leukemia (AML), the conventional therapeutic approach has not changed substantially, and the outcome for most patients is poor. Thus, continuous efforts on the discovery of new compounds with improved features are required. Following a multistep sequence, we have identified a new tetracyclic ring system with strong antiproliferative activity towards several haematological cell lines. The new compounds possess structural properties typical of inactive-state-binding kinase inhibitors and are structurally related to quizartinib which is known as type-II tyrosine kinase inhibitor. In particular, the high activi…
The Reactivity of 4’-Substituted Spiro[Isoindole-1,3’-pyrazoles] Derivatives: Substitution/Elimination Reactions and Access to Biaryl Derivatives
2017
This paper describes aspects of the chemistry of 4’-substituted spiro [indole-1,3’-pyrazoles]. These compounds underwent substitution and/or elimination reactions to afford some new spiro- as well as biaryl derivatives of potential pharmaceutical relevance. Mechanistic considerations are discussed as well.
2-(2-Iodoethyl)isoindole-1,3-dione
2007
The title compound, C10H8INO2, is an N-substituted phthalimide derivative in which the crystallographic intermolecular contact pattern consists of I⋯I, C—H⋯I, C—H⋯O and aromatic π–π interactions.
Methodological Guide for the Analysis of Teacher Issues : : Teacher Training Initiative for Sub-Saharan Africa (TTISSA) : Teacher Policy Development …
2011
This guide aims to permit an analysis of the different dimensions of the teacher issue in various countries, with the objective of building a global vision of this issue. The work that it aims to support is thus not descriptive but rather analytical. In essence, the goal is not to describe how this or that aspect of the system, such as teacher deployment or training, functions, but rather to analyze existing situations and the results obtained and to attempt to identify the range of options possible in the country. The analysis allows the identification of spaces for dialogue to define teacher policy
A novel pro-apoptotic role of zinc octacarboxyphthalocyanine in melanoma me45 cancer cell's photodynamic therapy (PDT)
2018
Abstract Zn-based phthalocyanine acts as drug or photosensitizer in photodynamic therapy (PDT) for the treatment of cancer cells. The activated zinc octacarboxyphthalocyanine (ZnPcOC) reacts with oxygen, to generate reactive oxygen species for the damage of melanoma cancer cells, Me45. This in vitro study aimed at investigating the cytotoxic effects of different concentrations of ZnPcOC activated with a diode laser (λ = 685 nm) on Me45, and normal human fibroblast cells, NHDF. To perform this study 104 cells/ml were seeded in 96-well plates and allowed to attach overnight, after which cells were treated with different concentrations of ZnPcOC (10, 20 and 30 μM). After 4 h, cells were irradi…
Forecasting Training Needs in the Hotel, Catering and Tourism Sector : A Comparative Analysis of Results from Regional Studies in Three European Coun…
2001
International audience; The European Union's recent LABOURatory project on "Regular Forecasting of Training Needs" was intended to explore labour-market information systems and methods in four EU Member States (France, Germany, Ireland and the Netherlands) and to compare them with data availability and applicable methods in three candidate countries (Czech Republic, Poland and Slovenia). The ultimate goal of the project, which was carried out under the Leonardo da Vinci programme, was the elaboration of a methodology for forecasting training needs that would be applicable in the context of labour markets in transition economies, as well as the improvement of existing prognostic approaches i…
Hypoxia-induced dysfunction of rat diaphragm
2004
Contains fulltext : 47331.pdf (Publisher’s version ) (Closed access) Oxidants may play a role in hypoxia-induced respiratory muscle dysfunction. In the present study we hypothesized that hypoxia-induced impairment in diaphragm contractility is associated with elevated peroxynitrite generation. In addition, we hypothesized that strenuous contractility of the diaphragm increases peroxynitrite formation. In vitro force-frequency relationship, isotonic fatigability, and nitrotyrosine levels were assessed under hypoxic (Po(2) approximately 6.5 kPa) and hyperoxic (Po(2) approximately 88.2 kPa) control conditions and also in the presence of authentic peroxynitrite (60 min), ebselen (60 min), and t…
Quels sont les besoins d'accompagnement pédagogique exprimés par les enseignants-chercheurs ?: Des pistes pour documenter le développement d'un centr…
2010
La formation pédagogique des enseignants universitaires s'installe en France, même s'il subsiste encore des conceptions de l'enseignement à l'université qui n'envisagent pas le métier comme une " métaprofession " (Arreaola et al., 2003) qui demanderait des expertises autres que disciplinaires. Dans le modèle de développement des Structures Universitaires de Pédagogie, questionner et analyser les besoins est une étape incontournable de la démarche d'ingénierie de formation. Il s'agit notamment d'éviter les lacunes relevées par Shulman (2000) et de ne proposer qu'un modèle additif de formation ou, au mieux, un modèle transformatif imparfait. Cette communication présente la démarche mise en ou…
Identification of patterns og change on mongitudinal data, illustrated by two exemples : study of hospital pathways in the management of cancer. Cons…
2014
Context In healthcare domain, data mining for knowledge discovery represent a growing issue. Questions about the organisation of healthcare system and the study of the relation between treatment and quality of life (QoL) perceived could be addressed that way. The evolution of technologies provides us with efficient data mining tools and statistical packages containing advanced methods available for non-experts. We illustrate this approach through two issues: 1 / What organisation of healthcare system for cancer diseases management? 2 / Exploring in patients suffering from metastatic cancer, the relationship between health-related QoL perceived and treatment received as part of a clinical tr…