Search results for "terase"

Frequencies of pseudocholinesterase variants in Icelanders, Greeks and Pakistanis.

1968

THE formation of the human pseudocholinesterase variants is controlled by at least four alleles at one autosomal locus termed E1 (ref. 1). The four alleles are , , and (refs. 2–5). The heterozygotes have been found in remarkably uniform frequencies, about 3 to 6 per cent, in Caucasians from Europe and North America3,8–11, and also in Australian aborigines12 and Mexican Indians13, but are relatively rare among Negroes11 and Mongoloids10,11,14.

STOP 8: Morphology and arrangement of glaciokarst kettles at Vietalva village

2014

Thiobencarb-Induced Changes in Acetylcholinesterase Activity of the Fish Anguilla anguilla

2002

Abstract European eels (Anguilla anguilla) were exposed to sublethal thiobencarb concentrations in a continuous flow-through system for 4 days. Brain, muscle, and gill acetylcholinesterase (AChE) activities were evaluated after 2, 12, 24, 48, 72, and 96 h herbicide exposure. Thiobencarb induced significant inhibitory effects on the total and specific AChE activity of A. anguilla, ranging from >30–40% inhibition in eel brain and gills to >50% inhibition in muscle tissue 2 h after the initial exposure. In a second experiment, eels were exposed to thiobencarb for 96 h and then allowed a period of recovery in pesticide-free water. Following 1 week of recovery, the AChE activity of affected eels…

Metal concentrations and detoxification mechanisms in Solea solea and Solea senegalensis from NW Mediterranean fishing grounds

2013

10 pages, 5 figures, 4 tables

New biodegradable hydrogels based on a photocrosslinkable modified polyaspartamide: synthesis and characterization

1999

Abstract α,β-Poly( N -2-hydroxyethyl)- dl -aspartamide (PHEA), a synthetic water-soluble biocompatible polymer, was derivatized with glycidyl methacrylate (GMA), in order to introduce in its structure chemical residues having double bonds and ester groups. The obtained copolymer (PHG) contained 29 mol% of GMA residues. PHG aqueous solutions at various concentrations ranging from 30 to 70 mg/ml were exposed to a source of UV rays at λ 254 nm in the presence or in the absence of N , N ′-methylenebisacrylamide (BIS); the formation of compact gel phases was observed beginning from 50 mg/ml. The obtained networks were characterized by FT-IR spectrophotometry and swelling measurements which evide…

Extracellular cyclic GMP and its derivatives GMP and guanosine protect from oxidative glutamate toxicity.

2013

Cell death in response to oxidative stress plays a role in a variety of neurodegenerative diseases and can be studied in detail in the neuronal cell line HT22, where extracellular glutamate causes glutathione depletion by inhibition of the glutamate/cystine antiporter system xc(-), elevation of reactive oxygen species and eventually programmed cell death caused by cytotoxic calcium influx. Using this paradigm, we screened 54 putative extracellular peptide or small molecule ligands for effects on cell death and identified extracellular cyclic guanosine monophosphate (cGMP) as a protective substance. Extracellular cGMP was protective, whereas the cell-permeable cGMP analog 8-pCPT-cGMP or the …

Anticomplementary Activity of Guinea Pig Serum Euglobulin: Its Relation to C 1 and to TAMe Esterase

1969

The interaction of complement with a suitable antigen-antibody aggregate triggers a chain of chemical reactions involving consecutively the nine factors of complement (C1 to C9). The triggering reaction is identical with the material fixation of Cl to the immune complex ; this leads to the formation of Ag-Ab-C1. By its fixation Cl is converted from its chemically inert form to a highly reactive state (“fixed” or “activated” C1). The reactivity of fixed Cl is directed first against C4. Consequently C4 rapidly disappears from the fluid phase in the presence of fixed Cl. A strikingly similar process occurs spontaneously in a fraction of guinea pig serum [5, 6].

Untersuchungen zum hereditären Angioödem im deutschsprachigen Raum

1998

In 6 Zentren der BRD, der Schweiz und Osterreichs wurden 242 Personen erfast, bei denen ein quantitativer und funktioneller Defekt des C1-Esterase-Inhibitors (C1-INH) biochemisch nachgewiesen und uber 2–6 Generationen verfolgt werden konnte. Bezogen auf die Gesamteinwohnerzahl der 3 Lander betragt die Frequenz des HAE auf der Basis der von uns erfasten Falle 0,02×10−4. Da unsere epidemiologischen Untersuchungen nicht flachendeckend erfolgten, ist mit einer um mindestens 1–2 Zehnerpotenzen hoheren Dunkelziffer zu rechnen. Innerhalb eines Kollektivs von 110 Personen mit klinischen Manifestationen eines hereditaren Angioodems (HAE) wurden retrospektiv anamnestische, klinische, Labor- und Thera…

Reduced inotropic support after aprotinin therapy during pediatric cardiac operations

1999

Several reports indicate that aprotinin treatment before and during cardiopulmonary bypass (CPB) might have a protective effect on the myocardium. We evaluated the hemodynamic effects of perioperative aprotinin treatment.We conducted a randomized, double-blind, placebo-controlled trial in 34 infants (mean age, 2.5 years) who had cardiac operations. Half of the patients received high-dose aprotinin therapy. There were no significant differences between the aprotinin and placebo groups with respect to age, weight, sex, aortic cross-clamp time, and CPB time. The following data were recorded at arrival in the intensive care unit 6, 12, 24, and 48 hours after termination of CPB: heart rate, bloo…

Functional C1-inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations

2008

Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The most widespread underlying genetic deficiency is a heterozygous deficiency of the serine protease inhibitor Cl esterase inhibitor (C1-Inh). In addition to low C4 levels, the most important laboratory parameter for correct diagnosis of HAE or angioedema due to acquired C1-Inh deficiency is reduced C1-Inh function (fC1-Inh). No direct recommendations about the assays for fC1-Inh or sample handling conditions are available, although this would prove especially useful when a laboratory first starts to offer assays on fC1-Inh for HAE diagnosis. In the p…