Search results for "terce"
showing 10 items of 394 documents
Comparative Studies on Vascular Endothelium in vitro
1995
Endothelial cells (EC) are very responsive to proinflammatory cytokines, e.g. interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha), as well as to bacterial lipopolysaccharide. EC are stimulated by these substances to secrete chemotactic factors and to increase expression of cell adhesion molecules (CAM), leading to dramatically altered interactions with leukocytes, e.g. granulocytes and monocytes. In these interactions E-selectin, ICAM-1 and VCAM-1 are known to play an important role, as they are presented by the EC and interact with corresponding ligands on the white blood cell membranes. These adhesion molecules have been studied worldwide in a variety of in vitro experiments …
Soluble E-Selectin Enhances Intercellular Adhesion Molecule-1 (ICAM-1) Expression in Human Tumor Cell Lines
1998
E-selectin mediates neovascularization via its soluble form, while its membrane-bound form initiates binding of tumor cells to vascular endothelium. Therefore, it was studied whether soluble E-selectin regulates further adhesion molecules on tumor cells. In tumor cells but not in related nonmalignant cells, intercellular adhesion molecule (ICAM)-1 expression was strikingly increased from 5 to 68% positive cells by in vitro inoculation of a recombinant E-selectin-IgG1 within 24 h, as analyzed by flow cytometry. The absence of changes in the expression of vascular cell adhesion molecule, integrin ligands (CD11a, CD18, integrin alpha 4), and sialyl-Lewis X indicates a specific effect of solubl…
Expression of cell adhesion molecules in inflammatory myopathies.
1995
We examined the expression of cell adhesion molecules in 25 cases of inflammatory myopathies. Inflammatory myopathies showed upregulation of adhesion molecules. ICAM-1 was strongly expressed on endothelial cells as well as on fibroblasts and infiltrating leukocytes while the expression of VCAM-1, similar in its distribution, was much weaker. A few muscle fibers in polymyositis revealed sarcolemmal labeling for ICAM-1. ELAM-1 showed only weak expression on vessels. The inflammatory cellular infiltrates contained varying amounts of cells bearing the VCAM-1 ligand VLA-4 and the ELAM-1 ligand SLeX as well as large amounts of cells expressing LFA-1 alpha and beta, ligands of ICAM-1.
Soluciones de las comunidades autónomas de régimen general a algunas deficiencias de la Ley 49/2002 de Régimen fiscal de las entidades no lucrativas …
2021
The current Law 49/2002 on the tax regime of non-profit entities and tax incentives for patronage was born out of the declared will to establish a set of incentives applicable to patronage activity in general and, in particular, to cultural patronage. However, the practical application to date of this commendable principle has been shown to be a mere normative proposition. The Autonomous Communities of the Balearic Islands, the Valencian Community and Castilla-La Mancha have enacted laws on tax incentives for cultural patronage that could resolve, within the scope of their competences, some difficulties encountered with state regulations. With this scenario in mind we analyze the effective …
Aplicación de la metodología ApS en alumnos del Grado de Logopedia: intervención con personas de la tercera edad.
2018
[EN] Service-learning (SL) is a methodology that contributes to the formation of values and the citizenship of university students, who can acquire a relevant role in the construction of a more dignified, inclusive, cohesive and equitable citizenship. The objective of the project is to relate and integrate the curricular objectives of the subject “Clinical Neurology applied to Speech Therapy” and the objectives of the community’s service. The proposed activity consisted of Speech Therapy second year students implementing the basic clinical propaedeutic (anamnesis, neurological and cognitive exploration) in elderly people, all framed in a service-learning activity. Some Speech therapy studen…
La utilización de la metodología ApS refuerza la adquisición de competencias a largo plazo
2019
[EN] Service-learning (SL) is a methodology that contributes to the formation of values and the citizenship of university students, who can acquire a relevant role in the construction of a more dignified, inclusive, cohesive and equitable citizenship. The objective of the work is to quantify how the SL methodology implemented in a subject improves the competences of the students in the same course of implementation and after one year of implementation. Four experimental groups were formed: a) group LS-course 2017-2018; b) group NO-LS-course 2017-2018; c) group LS-course 2018-2019; d) group NO-LScourse 2018-2019. Each one of the groups was evaluated during the academic year 2018-2019 in the …
La universidad española como plataforma de emprendimiento: hacia la universidad emprendedora del futuro
2017
[ES] Ha existido una evolución desde la tercera misión de la universidad preconizada por la Triple Hélice (ver trabajos de (Henry Etzkowitz & Leydesdorff, 2000), como elemento de transferencia de tecnología a la sociedad, en forma de convenios y contratos (ejemplo, Shane, 2002), licencias de patentes (ejemplo, Agrawal & Henderson, 2002) o incluso relaciones informales
The importance of tight junctions in the blood-brain barrier
2021
There are two barriers in the central nervous system (CNS) responsible for maintaining the homeostatic balance of the human body’s internal environment in relation to external conditions: the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). The blood-brain barrier is a physical barrier with a fixed location between the blood and the nervous tissue. Its basic structural elements include endothelial cells of the brain capillaries, astrocytes and pericytes. The blood-brain barrier is the barrier between the blood and neurons which isolates the central nervous system from the rest of the body in a unique manner. The blood-brain barrier is formed by astrocytes and per…
Intercettazioni no limits: il captatore informatico “per istradamento”
2021
L’utilizzo del captatore informatico a mezzo della tecnica dell’istradamento si presta a distorsioni e abusi. Ci si trova di fronte a uno strumento itinerante del quale è impossibile prevedere gli spostamenti, sommato a una tecnica captativa elusiva dei confini giurisdizionali. Dopo una breve ricostruzione degli interventi giurisprudenziali e legislativi che hanno consentito di disciplinare processualmente l’utilizzo del “virus-spia”, vengono messe in evidenza le aporie attualmente esistenti e si individuano i pretesti usati dalla prassi per una sempre più ampia fruibilità dei risultati delle intercettazioni con captatore. Con particolare riguardo alle primissime applicazioni giurisprudenzi…
Cross-talk between minimally primed HL-60 cells and resting HUVEC reveals a crucial role for adhesion over extracellularly released oxidants
2011
This study demonstrates that a long-lasting co-culture of neutrophil surrogates (HL-60 cells), minimally primed by platelet activating factor (PAF), and resting endothelial cells (EC) results in the elaboration of an hyper-adhesive endothelial surface, as measured by the increase in the expression of endothelial adhesion molecules E-Selectin, VCAM-1, and ICAM-1. This endothelial dysfunction is mediated by the activation of the redox-sensitive transcription factor NF-κB through an exclusive adhesion-driven mechanism active in the endothelial cell: reactive oxygen and nitrogen species, extracellularly released by minimally primed HL-60 cells, are not involved in the induction of the endotheli…