Search results for "topos"
showing 10 items of 153 documents
Clinical aspects and prognosis of ependymoma in infants and children
2001
Thirty-two patients (22 boys and 10 girls) with a histologically confirmed diagnosis of ependymoma were treated between 1972 and 1999. A total macroscopic resection was achieved in 16 of these patients, whereas 15 resections were classified by the surgeon as subtotal. In 1 patient a ventriculostomy was created as part of a palliative strategy. All children over 3 years old were treated with postoperative radiotherapy. Chemotherapy consisted of procarbazine, ifosfamide, etoposide, methotrexate, cisplatin and cytosine arabinoside. There was 1 perioperative death. Twenty children developed a relapse of disease within 2 months to 13 years and 1 month after the initial therapy. A maximal number …
Raw material procurement and selection in Southeast Iberia’s early metallurgy
2020
The role of metallurgy in the Copper Age communities of the Iberian Southeast is a recurrent question of archaeological research in western Europe. Based on lead isotope and trace element analyses of archaeometallurgical remains, this paper addresses the territorial organisation of metallurgical production during the Copper Age (3100-2200 cal BC) in the Vera Basin (Almería, Spain), the region with the earliest metallurgical evidence in western Europe. This paper comprises the study of materials from the three main settlements with metallurgical activity in the area (Las Pilas, Santa Bárbara and Almizaraque), as well as some metal objects from these and other sites (La Encantada I, Loma…
Histological characteristics of the vertebral intercentra of Metoposaurus diagnosticus (Temnospondyli) from the Upper Triassic of Krasiejów (Upper Si…
2012
ABSTRACTOsteohistological characteristics of the large temnospondyl amphibian Metoposaurus diagnosticus from the Upper Triassic of Poland (Krasiejów locality) were determined using vertebral intercentra thin-sections from different regions and growth stages. The intercentra showed a trabecular structure in both the endochondral and periosteal domains. Endochondral ossification developed first, and the primary bone occurs near the periphery with a higher degree of remodelling in the centre. Periosteal bone deposition begins later; first on the ventral side, continuing laterally and finally onto the dorsal side. Periosteal growth rate was initially very rapid, and then subsequently decreased …
Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells
2019
Recently approved cancer drugs remain out-of-reach to most patients due to prohibitive costs and only few produce clinically meaningful benefits. An untapped alternative is to enhance the efficacy and safety of existing cancer drugs. We hypothesized that the response to topoisomerase II poisons, a very successful group of cancer drugs, can be improved by considering treatment-associated transcript levels. To this end, we analyzed transcriptomes from Acute Myeloid Leukemia (AML) cell lines treated with the topoisomerase II poison etoposide. Using complementary criteria of co-regulation within networks and of essentiality for cell survival, we identified and functionally confirmed 11 druggabl…
Long bone histology of Metoposaurus diagnosticus (Temnospondyli) from the Late Triassic of Krasiejów (Poland) and its paleobiological implications
2013
ABSTRACT Long bones of the temnospondyl Metoposaurus diagnosticus krasiejowensis from the Late Triassic of Krasiejow, Poland, were studied using histological analysis. Six femora, three humeri, a radius, and an ulna were prepared for thin-sectioning. In all bones, the dominant type of primary bone matrix is parallel-fibered bone with secondary, or rarely primary, deposition of lamellar bone inside vascular canals. Two small humeri and the smallest femur showed incipient fibrolamellar bone, which may be a character typical for juvenile individuals. The medullary region is filled with well-developed trabecular bone. The growth marks in all bones are organized as thick layers of highly vascula…
Unique growth pattern of Metoposaurus diagnosticus krasiejowensis (Amphibia, Temnospondyli) from the Upper Triassic of Krasiejów, Poland
2013
Morphology and bone histology of femora, tibiae, and fibulae of the temnospondyl Metoposaurus diagnosticus krasiejowensis from the Upper Triassic locality of Krasiejow (Poland) are studied for the first time. The growth pattern of Metoposaurus as preserved in a small growth series of femora, shows a regular alternating sequence of fast and slow growth phases, which are interpreted as representing zones and annuli. The slow growth phases (annuli) of the inner and outer cortex as well as those of different specimens are of a regular broad thickness. Such broad annuli are so far unknown for any vertebrate and make the growth pattern for Metoposaurus unique. These slow growth phases always cont…
Unraveling the origin of the Late Triassic multitaxic bone accumulation at Krasiejów (S Poland) by diagenetic analysis
2012
Abstract A study of aquatic and terrestrial vertebrate remains from a bonebed in the Late Triassic continental succession near Krasiejow (S Poland) shows it was deposited by a single catastrophic event, perhaps a flood. Hardparts of Metoposaurus, Paleorhinus, and Stagonolepis show sedimentary infill and geochemical evidence for early diagenesis at different times and in different microenvironments. The infills in the aquatic animal bones (sediment, pyrite and calcite) show deposition in a freshwater environment, while those in the terrestrial Stagonolepis remains (mainly barite) point to an arid terrestial environment. The trace element content of the remains, together with the absence of a…
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation
2008
The Werner syndrome helicase/3′-exonuclease (WRN) is a major component of the DNA repair and replication machinery. To analyze whether WRN is involved in the repair of topoisomerase-induced DNA damage we utilized U2-OS cells, in which WRN is stably down-regulated (wrn-kd), and the corresponding wild-type cells (wrn-wt). We show that cells not expressing WRN are hypersensitive to the toxic effect of the topoisomerase I inhibitor topotecan, but not to the topoisomerase II inhibitor etoposide. This was shown by mass survival assays, colony formation and induction of apoptosis. Upon topotecan treatment WRN deficient cells showed enhanced DNA replication inhibition and S-phase arrest, whereas af…
Characterization of sea turtles aggregations in Uruguay (Southwestern Atlantic Ocean): the ecology of the green turtle in temperate waters
2017
Introducción Actualmente existen siete especies de tortugas marinas. Estas son la tortuga laúd o siete quillas (Dermochelys coriacea) como única especie representante de la familia Dermochelyidae, y las seis especies vivientes de la familia Cheloniidae: la tortuga carey (Eretmochelys imbricata), la tortuga lora (Lepidochelys kempii), la tortuga olivácea (Lepidochelys olivacea), la tortuga boba o cabezona (Caretta caretta), la tortuga verde (Chelonia mydas) y la tortuga aplanada (Natator depressus) (Meylan & Meylan 1999). Las tortugas marinas tienen una distribución circunglobal, encontrándose en todos los océanos del mundo excepto en las regiones polares, ocupando nicho ecológicos únicos y …
Ética del discurso: ¿un marco filosófico para la neuroética?
2013
Neuroethics requires a framework of philosophical ethics from which to interprete, integrate and criticiseneuroscientific progress in moral field. This article sets out to: 1) Show to what extent this framework is necessary; 2) Tackle the question of the method for constructing this framework; 3) Compile the main tópoi of the neurosciences that the framework has to interpret and integrate; 4) Propose the ethics of discourse as a philosophical framework for neuroethics; 5) Display certain shortcomings of this framework and put forward the dialogical ethics of cordial reason as being more appropriate.La Neuroética necesita un marco de ética filosófica desde el que interpretar, integrar y crit…