Search results for "valuation"
showing 10 items of 2494 documents
Archaeological tourism: looking for visitor loyalty drivers
2019
Revisit intention has become a focus of attention for archaeological sites management. Identifying visitors’ loyalty drivers to any tourism attraction is crucial but it is even more necessary for t...
Apoptosis and cell growth arrest in A375 human melanoma cells by diorganotin(IV) and triorganotin(IV) complexes of [meso-Tetra(4-sulfonatophenyl)porp…
2011
In previous studies we have demonstrated that two derivatives of meso-Tetra(4-sulfonatophenyl)porphine (TPPS), (Bu2Sn)2TPPS and (Bu3Sn)4TPPS, cause apoptotic death of A375 melanoma cells and, at lower concentrations, arrest of cell proliferation. In the present study, we examined if the manganese metal inside the porphyrin cavity could improve the efficacy of this class of compounds. Thus, [meso- Tetra(4-sulfonatophenyl)porphine]Mn(III)Cl (=MnTPPS) derivatives, namely (Me2Sn)2MnTPPS, (Bu2Sn)2MnTPPS, (Me3Sn)4MnTPPS and (Bu3Sn)4MnTPPS, were tested on the A375 human melanoma cell line. A cytotoxicity assay showed that (Bu2Sn)2MnTPPS and (Bu3Sn)4MnTPPS were highly cytotoxic by inducing apoptosi…
INDICATORI PER LA VALUTAZIONE DELL'APPROPRIATEZZA DEL PERCORSO NASCITA
2015
Introduzione:La gravidanza, il parto ed il puerperio sono eventi fisiologici che possono talvolta complicarsi in modo non prevedibile e con conseguenze gravi per la donna, per il nascituro e per il neonato. Gli standard nazionali prevedono la razionalizzazione/riduzione progressiva dei punti nascita con numero di parti inferiore a 1000/anno, e l'abbinamento per pari complessità di attività delle UU.OO. ostetrico-ginecologiche con quelle neonatologiche/pediatriche, riconducendo a due i precedenti tre livelli assistenziali. I punti nascita privi di una copertura di guardia medico-ostetrica, anestesiologica e medico pediatrica attiva h 24, o di risorse umane e di attrezzature adeguate non dovr…
A Multistep Methodology for the Evaluation of Human Resources Using the Evidence Theory
2013
Synthesis and Antileukemic Activity of New 3-(5-Methylisoxazol-3-yl) and 3-(Pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones.
2003
3-(3-Methylisoxazol-5-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones 8a–l and 9a,c–e,h–l were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 6 and 8 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 8a–l and 9a,c–e,h–l were tested in vitro for their antileukemic activity against L-1210 (murine leukemia), K-562 (human chronic myelogenous leukemia) and HL-60 (human leukemia) cell lines showing in some cases good activity.
New Cathepsin Inhibitors to Explore the Fluorophilic Properties of the S 2 Pocket of Cathepsin B: Design, Synthesis, and Biological Evaluation
2011
5 páginas, 1 figura, 2 tablas -- PAGS nros. 5256-5260
Screening Investments to Reduce the Risk of Hydrologic Failures in the Headwork System Supplying Apulia (Italy) – Role of Economic Evaluation and Ope…
2014
The paper introduces and applies a methodology to screen investments aimed at reducing water supply risks due to hydrologic failures in headwork systems for municipal use, based on the principles of cost-benefit analysis. As risk includes both the probability of a failure and its effect, the methodology combines a simulation module of the system, fed by a stochastic hydrologic input to reproduce the probability distribution of the failures, with a metric for supply failure damage provided by the price – demand relationship for municipal water. Benefits are assessed as the averted damage compared to a base case without investments. This approach is then combined with the classic discounted c…
Sampling of Residential Water Use for Leak Control via Water Budgets
2009
Uncertainty assessment of an integrated urban drainage model
2009
Over the last few years, the use of mathematical models has gained importance in urban drainage system management; indeed, such models enable the combined analysis of different components that constitute a drainage system; the sewer system, wastewater treatment plant and the receiving water body. The effectiveness of an integrated approach has been widely demonstrated in the past and is presented in the EU Water Framework Directive, which also introduces a new point of view regarding the water quality management of the whole system, requiring a global analysis at the river basin scale for pollutant sources. However, integrated urban drainage models introduce several uncertain factors that a…
Evaluation of enantioselective binding of basic drugs to plasma by ACE.
2007
The present paper deals with the evaluation of the stereoselective binding of antihistamines (brompheniramine, chlorpheniramine, hydroxyzine, orphenadrine and phenindamine), phenothiazines (promethazine and trimeprazine) and a local anesthetic (bupivacaine) to human plasma proteins. Since all of them are drugs highly bound to proteins, a methodology to determine the bound fraction of each drug enantiomer was proposed. This methodology includes the incubation of samples containing plasma and racemic drug, ultrafiltration of the mixture and the chiral separation of enantiomers in the bound drug fraction using affinity EKC (AEKC)-partial filling technique and HSA as chiral selector. The result…