Search results for "very"

Views of Schizophrenia Among Future Healthcare Professionals: Differences in Relation to Diagnostic Labelling, Causal Explanations, and Type of Acade…

2021

Objective: Stereotyped beliefs about schizophrenia are well-established in the society and relatively common among healthcare professionals and students. The aim of this study was to investigate the opinions about the causes, treatment, and outcome of schizophrenia among healthcare students. Method: Undergraduate nursing and psychology students completed selected items of the Opinion on Mental Illness Questionnaire after reading a clinical vignette of undiagnosed schizophrenia. Results: Students who labelled the description as schizophrenia were more pessimistic regarding full recovery from the disorder. Those who acknowledged greater relevance to biogenetic risk factors were more convinced…

Design and Characterization of Effective Ag, Pt and AgPt Nanoparticles to H₂O₂ Electrosensing from Scrapped Printed Electrodes.

2019

The use of disposable screen-printed electrodes (SPEs) has extraordinarily grown in the last years. In this paper, conductive inks from scrapped SPEs were removed by acid leaching, providing high value feedstocks suitable for the electrochemical deposition of Ag, Pt and Ag core-Pt shell-like bimetallic (AgPt) nanoparticles, onto screen-printed carbon electrodes (ML@SPCEs, M = Ag, Pt or AgPt, L = metal nanoparticles from leaching solutions). ML@SPCEs were characterized by scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy. The results were compared to those obtained when metal nanoparticles were synthesised using standard solutions of metal salts (MS@…

Viatge i descoberta: Superant límits

2013

Tot viatge, fins el més banal, té una dimensió de descoberta, tant del món exterior com del mateix viatger. Alguns viatgers, però, han fet i fan de la recerca mateixa l’objecte del viatge. Els objectius, els mitjans i els comportaments d’aquests viatgers han variat al llarg de la història.

Testing the Modified Sediment Delivery Model (MOSEDD) at SPA2 Experimental Basin, Sicily (Italy)

2017

A new version of a spatially distributed sediment delivery model taking into account the hillslope sediment transport efficiency, named MOSEDD, is presented. This model gives estimates of basin sediment yield at event scale, which are more reliable than those obtained by the original SEDD. For SPA2 basin discretized into morphological units, four different calculation schemes of MOSEDD, including the original SEDD version, were applied. All parameterization schemes of the model were calibrated using 15 events measured at the outlet of the experimental basin in the period February 2005–February 2010. The model calibration was used to determine a relationship between the coefficient βe of the…

Who Can See My Stuff? : Online Self-Disclosure and Gender Differences on Facebook

2018

This study investigates the gendered privacy practices and concerns on Facebook, by leaning on the idea of privacy management as a form of digital labour. We analyse if young Facebook users are more concerned about the privacy against other users than against Facebook as a company or against third-party partners. We also analyse if privacy concerns and visibility rules are differentiated by gender. Using a structured online survey, we collected responses from a sample of 813 Italian university students (aged 18-34). Our results show that the respondents have just slightly more privacy concerns against other users than against Facebook, and much less against third-party partners. Unlike a ma…

Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum

2012

WOS: 000306752700042

Delivery of shNupr1 plasmid by solid lipid nanoparticles reduces the expression of Nupr1 gene in hepatocellular carcinoma cells

2015

Polymeric nanoparticles for siRNA delivery: Production and applications

2017

Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…

Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.

2021

Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…

Development of different nanosystems for drugs and siRNA delivery

Cancer is one of the leading causes of death in the world. Over the past several decades, the development of engineered nanosystems for targeted drug delivery have received great attention thanks to their possibility to overcome the limitations of classical cancer chemotherapy including poor solubility, targeting incapability, nonspecific action and, consequently, systemic toxicity. In this contest, four different models of nanocarriers have been analysed and compared for their capacity to target tumour tissue and to release the therapeutic agent in a controlled way: INU-EDA-P,C-DOXO; PHEA-EDA-P,C-DOXO; PVP-siRNA and RGO-siRNA. Inulin and PHEA were conjugated to the antineoplastic drug doxo…