Search results for "very"

The Nasal Epithelium as a Factory for Systemic Protein Delivery

2002

We have previously shown that recombinant Sendai virus (SeV) produces efficient in vivo airway epithelial gene transfer. The ability to produce therapeutic levels of circulating proteins following noninvasive gene transfer would have widespread clinical application. Here, we compared nose, lung, and skeletal muscle for the ability to produce circulating levels of the secreted mouse antiinflammatory cytokine interleukin-10 (IL10) following SeV-mediated gene transfer. High levels of serum IL10 were obtained from each site with a potency order of lung > nose > muscle for a given viral titer. Serum levels from each site were within the likely required range for anti-inflammatory effects. The co…

Tumor targeting of baculovirus displaying a lymphatic homing peptide.

2008

Background Tumor-associated cells and vasculature express attractive molecular markers for site-specific vector targeting. To attain tumor-selective tropism, we recently developed a baculovirus vector displaying the lymphatic homing peptide LyP-1, originally identified by ex vivo/in vivo screening of phage display libraries, on the viral envelope by fusion to the transmembrane anchor of vesicular stomatitis virus G-protein. Methods In the present study, we explored the specificity and kinetics of viral binding and internalization as well as in vivo tumor homing of the LyP-1 displaying virus to elucidate the applicability of baculovirus for targeted therapies. Results We demonstrated that th…

Incursioni dello straordinario nell’ordinario

2021

Si tratta di un commento al volume di Salvatore Settis, "Incursioni. Arte contemporanea e tradizione", Feltrinelli, 2020. La nota si inserisce in un dialogo a più voci a cura di Monica Centanni e Giuseppe Pucci dal titolo "Una lettura corale di: Salvatore Settis, Incursioni. Arte contemporanea e tradizione, Feltrinelli, 2020" La nota rilegge il volume di Settis mettendo a fuoco due autori: Bill Viola e Giuseppe Penone e collega questi artisti a una riflessione filosofica più ampia che mira a cogliere lo straordinario dell'arte e della natura nella vita di ogni giorno.

Dziesmas vārdu krājuma apguvei angļu valodas nodarbībās pirmsskolā

2017

Agrīna valodu mācīšanās kļūst arvien populārāka visā Eiropā pēdējo desmitgažu laikā, un šo tendenci var novērot arī Latvijā, angļu valodu apgūst pirmsskolas izglītības iestādēs un bērnudārzos visā valstī. Bērni nemācās svešvalodu tāpat kā pieaugušie, tāpēc ir nepieciešams, lai valodu mācītu pirmsskolas audzēkņiem atbilstoši viņu vecumam un briedumam, lai nodrošinātu to, ka mācības ir efektīvas un metodes, kas tiek izmantotas, ir piemērotas audzēkņiem. Galvenā mācību forma bērniem pirmskolā ir rotaļnodarbība, mācīšanās izmantojot rotaļas: dziedot dziesmas, mācoties skaitām pantus, dzejoļus, stāstus, kustību rotaļas, veicot uzdevumus, kas ietver zīmēšanu, krāsošanu, griešanu un līmēšanu, liek…

Recovery of mobility function and life-space mobility after ischemic stroke: the MOBITEC-Stroke study protocol

2020

Abstract Background Stroke is a major cause of disability and stroke incidence increases with age. Stroke frequently results in permanent limitations of mobility, and, consequently, the need for the help of others in activities of daily living. In order to optimize rehabilitative efforts and their functional outcomes, detailed knowledge of the functional recovery process, regarding mobility, is needed. Objectives of the MOBITEC-Stroke study are: 1.) To characterize mobility, including lower extremity physical function (LEPF) and life space (the geospatial extent of all of a person’s movements), and changes in mobility within the first year after stroke. 2.) To identify and characterize subg…

Waste heat recovery from a marine waste incinerator using a thermoelectric generator

2012

Published version of an article published in the journal: Journal of Electronic Materials. Also available from the publisher at: http://dx.doi.org/10.1007/s11664-012-2009-6 A marine waste incinerator has been evaluated for waste heat harvesting using thermoelectric generators (TEG). The application has been evaluated using mathematical modeling to optimize the heat exchanger and some vital design parameters of the TEG. The calculation shows that it is possible to extract 58 kW el at a price of 6.6 US$/W from an 850-kW th incinerator when optimizing for maximum power. However, minimizing the cost, it is possible to get 25 kW el at a price of 2.5 US$/W. A trade-off between the two targets lea…

The Effect of Emotional Dissonance and Mental Load on Need for Recovery and Work Engagement among Italian Fixed-Term Researchers

2020

Although many studies have been conducted to evaluate the risk and protective factors on psychological health among academic staff, little attention has been paid to fixed-term researchers, the weakest figures in the academic context. By using the Job Demands&ndash

Illegitimate tasks in health care: Illegitimate task types and associations with occupational well-being.

2021

Aims and objectives: The aims of the study were to identify content categories of unreasonable and unnecessary illegitimate tasks and to investigate how unreasonable and unnecessary tasks relate to occupational wellbeing. Background: Illegitimate tasks are a common stressor among healthcare professionals, and they have been shown to have negative associations with occupational well-being. Despite this evidence, research has not yet uncovered what kinds of tasks healthcare professionals consider illegitimate. Design and method: The data gathered by means of an online survey consisted of 1024 municipal healthcare organisation employees. A theory-driven qualitative content analysis was used to…

Temperature-responsive degalactosylated xyloglucans as nanocarriers for the sustained release of hydrophobic drugs

2013

Assessment of Knowledge, Attitudes, and Propensity towards HPV Vaccine of Young Adult Students in Italy

2020

Background: Human Papillomavirus (HPV) is a common sexually transmitted infection (STI), representing the main cause of genital warts and cervical cancer. This cross-sectional study evaluated knowledge and attitudes about HPV infection, related diseases, and prevention and propensity towards HPV vaccine among undergraduate students. Methods: An online and written survey about HPV and its prevention, targeted to young adults of both genders, was addressed to students attending health sciences and other schools at Universities of Genoa and Bari. Results: The overall median knowledge and attitude scores were 56.3% (25&ndash