0000000000155163
AUTHOR
Chen Y
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, …
The ARGO-YBJ Experiment Progresses and Future Extension
Gamma ray source detection above 30 TeV is an encouraging approach for finding galactic cosmic ray origins. All sky survey for gamma ray sources using wide field of view detector is essential for population accumulation for various types of sources above 100 GeV. To target the goals, the ARGO-YBJ experiment has been established. Significant progresses have been made in the experiment. A large air shower detector array in an area of 1 km2 is proposed to boost the sensitivity. Hybrid detections with multi-techniques will allow a good discrimination between different types of primary particles, including photons and protons, thus enable an energy spectrum measurement for individual species. F…
Background radioactivity in the scaler mode technique of the Argo-YBJ detector
""ARGO-YBJ is an extensive air shower detector located at the Yangbajing Cosmic Ray Laboratory (4300 ma.s.l., 606 g cm^−2 atmospheric depth, Tibet, China).. It is made by a single layer of Resistive Plate Chambers. (RPCs, total surface ~ 6700 m^2) grouped into 153 units. called “clusters”. The low energy threshold of the experiment is obtained using the ”scaler operation mode”, counting all the particles hitting the detector without reconstruction of the shower size and arrival direction. For each cluster the signals generated by these particles are put in coincidence in a narrow time window (150 ns) and read by four independent. scaler channels, giving the counting rates of channel. >= 1, …
Liraglutide and Renal Outcomes in Type 2 Diabetes.
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary end point (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes) and death. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are unknown. METHODS: We report the prespecified secondary renal outcomes of that randomized, controlled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a co…
Evidence for the direct two-photon transition from ψ(3686) to J/ψ.
The two-photon transition ψ(3686)→γγJ/ψ is studied in a sample of 1.06×10(8) ψ(3686) decays collected by the BESIII detector. The branching fraction is measured to be (3.1±0.6(stat)(-1.0)(+0.8)(syst))×10(-4) using J/ψ→e(+)e(-) and J/ψ→μ(+)μ(-) decays, and its upper limit is estimated to be 4.5×10(-4) at the 90% confidence level. This work represents the first measurement of a two-photon transition among charmonium states. The orientation of the ψ(3686) decay plane and the J/ψ polarization in this decay are also studied. In addition, the product branching fractions of sequential E1 transitions ψ(3686)→γχ(cJ) and χ(cJ)→γJ/ψ(J=0,1,2) are reported.
Gamma ray sources observation with the ARGO-YBJ detector
In this paper we report on the observations of TeV gamma ray sources performed by the air shower de- tector ARGO-YBJ. The objects studied in this work are the blazar Markarian 421 and the extended galactic source MGROJ1908+06, monitored during 2 years of operation. Mrk421 has been detected by ARGO-YBJ with a statisti- cal significance of 11 standard deviations. The observed TeV emission was highly variable, showing large enhance- ments of the flux during active periods. The study of the spectral behaviour during flares revealed a positive correla- tion of the hardness with the flux, as already reported in the past by the Whipple telescope, suggesting that this is a long term property of the…