Liraglutide and Renal Outcomes in Type 2 Diabetes.

6533b85ffe1ef96bd12c1be8

RESEARCH PRODUCT

Liraglutide and Renal Outcomes in Type 2 Diabetes.

Mann Jfe ØRsted Dd Brown-frandsen K Marso Sp Poulter Nr Rasmussen S Tornøe K Zinman B Buse Jb Leader Steering Committee And Investigators. Bergenstal R Daniels G Moses Ac Nauck M Nissen S Pocock S Steinberg W Stockner M Kristensen P Ravn Ls Zychma M Flyvbjerg A Ford I Kloos Rt Schactman Mj Sleight P Swedberg K Tenner Sm Akalın S Arechavaleta R Bain S Babkowski Mc Benroubi M Berard L Comlekci A Czupryniak L Eliasson B Eriksson M Fonseca V Franek E Gross J Hafidh K Haluzik M Hayes F Huang Yy Jacob S Kaddaha G Khalil A Kilhovd B Laakso M Leiter L Lalic N Ji L Luedemann J Mannucci E Marre M Masmiquel L Mota M Omar M O’shea D Pan C Petrie J Pieber T Pratley R Raz I Rea R Rutten G Satman I Shestakova M Simpson R Smith D Tack C Tarnow L Thomas N Van Gaal L Travert F Vidal J Warren M Yoon Kh Tuttle Rm Sheerman Si Hegedüs L Baerwald H Bergenstal M Celik S Dias C Eder M Fitzgibbons S Irvhage L Kloluckova J Kriulianski R Mcduffie R Moen S Paster A Saalfeld Rm Sankar K Shehaj E Swierzewska P Tiktin M Tovey S Gibson Cm Chakrabarti Ak Dashe Jf Hinchey J Leary Mc Pride Y Wiviott S Allen S Mehr Ap Mutter Wp Parikh S Ray S Cheifetz A Leffler D Sheth S Alexander E Gaglia Jl Goessling W Mitzner Ld Rosenberg C Snow Kj Wagner A Piazza G Abell S Davis T D'emden M Ding Sa Gilfillan C Greenaway T Gunawan F Ho J Jackson R Kalra B Lau Sl Lin J Macisaac R Makepeace A Malabu U Marjason J Mccallum R Mclean M Moin N Petersons C Price S Roberts A Roberts D Sangla K Stranks S Tan Y Thynne T Walters J Ward G Wen W Zhang J Brix J Feder A Höbaus C Höllerl F Höller V Kotter T Kratz E Krzizek Ec Leb-stoeger U Mader J Mras N Novak E Obendorf F Peric S Pesau G Prager R Ribitsch A Schnack C Schernthaner G Schernthaner G Wascher T Batens Ah Benhalima K De Block C Ernest P Fouckova A Jandrain B Lapauw B Letiexhe M Mathieu C Neven S Peiffer F Ruige J Scheen A Taes Y Van Boxelaer I Vandistel G Van Durme Y Verhaegen A Alencar E Alencar R Almeida Ac Alves B Alves E Alves G Alves J Araujo L Arruda V Augusto Ga Baggentoss R Balestrassi L Barbosa M Barcelos I Belem L De Bem A Betti Rt Bona R Bosco A Branda J Bronstein M Bueno T Bulcão T Caiado F Camazzola F Cambréa Mf Campos S Campos S Canani L Carra Mk Caruso S Carvalho N Casillo A Castro D Cavalcanti T Cavichioli V Cercato C Chacra A Challela W Charchar Hs Chaves C Chrisman C Chrisman C Correia-deur J Da Costa A Jr Costa M Costi B Coutinho P Coutinho W Cunha Mr Daher J Jr Davini E Democh D Jr Eliaschewitz F Esmanhoto Facin G Farias F Felício J Fernandes V Filho Cs Filho Ff Filho M Fontan D Fontenele Ap Forti A Franco D Freire K Fusaro A Genestreti P Gerchman F Godi A Gomes Kf Gonçalves P Gonçalves R Griz L Grossman M Gurgel Mh Vasconcellos Haddad Aw Halpern A Hissa M Inuy A Jaime J Jonasson T Jorge Jc Malucelli Fj Kohara S Kramer C Lacerda C Ladeira S Lana J Lastebasse F Leitão A Leite S Lerário Ac Lima D Lima M Lippi V Lunardi M Machado E Maia F Maia J Maia Kp Mañas N Marchisotti F Marinho C Martins C Figueiredo De Medeiros F Melo A Melo F Mendonca E Mendonça P Filho Rm Miguel M Miléo K Miyahara M Montenegro Ap Moraes A Moreira A ÍTalo Mota J Mothe Fs Murro A Nakatani V Napoli Tf Neto Bg Neto Oq Niclewicz E Ohe Ln Oliveira F Oliveira M Panarotto D Parente E Parolin S Pechmann L Costa Da Penha P Perlamagna L Perotta B Pimentel L Pinto M Poço C Ponte C Prazeres P Quintao E Raduan R Rassi Dt Rassi N Reck L Montenegro R Jr Ribeiro R Rodovalho S Silveira Rodrigues G Rollin G Rossi S Sabino C Sales Ap Salles J Sampaio Cr Santana L Sato V Da Silva Santos M Santos Nl Santos R Saraiva J Sartori C Sena R Sevilha M Sgarbi J Silva D Silva D D'albuquerque Silva L Silva Me Siqueira K Soares S Sobreira W Sousa B Souza Ac Souza B Tambascia M Tarantino R Tenor F Tomarchio M Triches C Tristão Lj Valenti A Vasques E Vencio S Vianna A Munhoz Vidotto T Vieira S Villar H Visconti G Volaco A Wajchenberg B Zanatta L Zimmerman L Abbott Ec Abu-bakare A Advani A Allison R Bishara P Bowering Ck Cheng A Chouinard S Clayton D Conway J D'amours M De Tugwell B Deyoung P D'ignazio G Dube F Ekoe Jm Fagan S Garceau C Gottesman I Hanna A Harris S Hramiak Im Hurd C Imran S Josse R Joyce C Kaiser S Khan F Kirouac I Kovacs C Labonte I Langlois Wj Levac Mf Liutkus J Mcdonald C Milosevic V Nyomba Bl Paul T Raby K Ransom T Reichert Sm Retnakaran R Rabasa-lhoret R Raff E Shaikholeslami R Sigalas J Yip Ce Weisnagel Sj Woo V Bao Y Cai X Chen J Chen K Chen M Chen X Chen Y Ji Y Lei J Li H Liu P Mu Y Ren M Ren Y Shi Y Wang D Wang F Wang J Wang Y Yan L Yang G Yang J Yu X Yuan G Xu M Zhao X Zheng J Zhou L Anderlová K Brožová J Haluzík M Hanušová V Kosák M Křížová J Mráz M Owen K Rušavý Z Tomešová J Trachta P ŽOurek M Andersen Ph Boesgaard T Christensen S Gram J Gregersen S Henriksen Je Hermansen K Jakobsen Pe Jensen J Krogsaa A Larsen M Lervang Hh Madsbad S Mortensen L Olesen T Pietraszek A Ridderstråle M Safai N Schioldan Ag Schmidt C Snorgaard O Stidsen J Cederberg H Haapamäki H Hukkanen J Jauhiainen R Kujari Ml Lahtela J Laine M Mäkelä J Miilunpohja M Savolainen M Taurio J Vänttinen M Creton C Cosma Nv Dillinger J Jacques Jl Guedj Am Moulla M Petit C Ratsianoharana V Richter D Rodier M Roussel R Hinz A Politz E Esser M Deuse U Mittag D Hagenow A Jacob F Jordan R Gantke D Venschott-jordan U Löhr C Klausmann G Eschenbrücher K Karakas M Jahrsdörfer B Kunze Mr Wöhrle J König W Spielhagen H Kilimnik A Lüdemann Hp Lüdemann J Mölle A Mölle M Müller J Appelt S Sauter A Sauter J Hartmann U Löw A Krötz F Sohn Hy Von Schacky C Klauss V Braun D Segner A Degtyareva E Kreutzmann K Paschmionka R Hauck N Sihal O Busch Ak Maus O Stübler P Füllgraf-horst S Vietzke A Müller C Tosch-sisting R Lengsfeld B Thaler J Schaum T Steindorf J Steindorf S König A Reitschuster S Schlott D Clever Hu Witzel P Kempe Hp Stemler L Benis A Diakoumopoulou E Kazakos K Kypraios N Liatis S Pagkalos E Siami E Tentolouris N Alur Vc Agrawal M Ali M Asirvatham A Asirvatham E Bandgar Tr Balaji M Bardoloi N Baruah M Bekur R Bhansali A Bhatia S Bhonsley S Bhuyan S Borah B Bright N Ambrish C Chaudhury T Choudhury S Chellan G Das M Dharmalingam M Dutta P Erugu A Vinutha Fp Gunasekaran P Das Gupta R Iqbal A Jagadish P Jain S Jain S Jebasingh H John A John M Kalra B Kalra S Kasaragod P Kesavadev J Kumar H Kumar P Lakshmanan V Lila Ar Mathew T Miyen H Mohan T Motha A Murthy C Shivashankara N Nanaiah A Ommen T Pani K Pandey K Paramesh S Paramesh V Pillai B Prabhu M Kalki Rc Ramachandran S Ramu M Rao Y Reddy S Saikia P Saravu K Selvam K Sethi B Shankar A Sharma A Shah N Shankar P Shetty R Shivane V Srivalli S Thaseen S Sarada S Shirisha A Subramani M Balaji V Mohan V Padmanaban V Verma M Vidyasagar S Walinjkar V Walia R Davenport C Forde H Gadintshware G Gan Kj Khattak A O'connell J O'shea D Beilin V Cahn A Cohen O Cukierman-yaffe T Daoud D Darawsha M Dicker D Gavish A Hochberg I Ilany J Inbal U Itzhak B Karasik A Karnieli E Khader N Khamaisi M Lender D Lieberman Gs Mahamid R Marcoviciu D Michael L Minuchin O Mosenzon O Narevichius F Percik R Potekhin M Sabbah M Sawaed S Schurr D Segal E Slezak L Vollach I Zaina A Zloczower M Zolotov S Antenore A Arnone M Arturi F Barbaro V Barone M Di Biagio R Buscemi C Buscemi S Buzzetti R Di Carlo A Carlone A Caruso V Casadidio I Cerrelli F Ciavarella A Cipolloni L Colella A Colotto M Consoli A Crippa Vg Cuccuru I Cufone S Desideri C Fallarino M Febo F Filetti S Foffi C Formoso G Frosio L Di Fulvio P Gambineri A Ginestra F Grimaldi Ms Lamanna C Leto G Lucotti P Lugarà M Lumera G Magistro A Maranghi M Martelli D Mattina A Monti Ld Parise M Pedace E Perticone F Piatti P Pompea Antonia Baldassarre M Ragghianti B Repaci A Ribichini D Da Ros S Rossi M Santilli M Sesti G Setola E Succurro E Sussolano E Tarquini G Verga S Vitale V Alanis Rr Del Rosario Arechavaleta-granell M De Jesús Beltran Jaramillo T De Jesús Rodríguez Berrones Da Rodríguez Briones I Rodríguez Briones R Acevedo Castañeda Es Chapa Grimaldo Jb Flores-moreno Ca Garza Felix S Nieto Flores J Morales Franco G Garza Morán Ra Hernández González So González-gálvez G González González Jg Hernández Salazar E García Hernández Pa Campos Hurtado S López-velázco Ml Cardona Muñóz Eg Nuñez Márquez R Campos Moreno Ov Cavazos Oliveros Fj Haro Ortiz Ja Pelayo-orozco Es Sida Perez P Vazquez Ramírez R Uribe Rios Ma López Rodríguez Jc Rodríguez Rosales M Robledo Durón I Alvarado Ruíz R González Saldivar G Reyes Sánchez R Sánchez-michel Bl Contreras Sandoval Ay Velasco Gutiérrez A Perez Verdín Ae Ramos Zavala Mg Abbink-zandbergen E Ahdi M Bugter A Van Dijk M Eisma G Erdtsieck R Gerards M Gerdes V Haak H Harbers V Hoogenberg K Huvers F Janssen W Kars M Kooy A Lafeber M Landewé-cleuren S Lieverse A Meesters E Moerman S Van Moorsel D Nijhuis J Smit Cj Tack C Thevissen K Timmerman Thijssen Dm Willemsen A Birkeland K Cooper J Gulseth H Hjelmesæth J Jørgensen P Kilhovd Bk Kulseng B Nicolaisen B Skadberg Ø Wium C Antkowiak-piatyszek K Arciszewska M Bajkowska-fiedziukiewicz A Bogdanski P Czubek U Cypryk K Dabrowski J Dabrowska M Dziedzic S Dziewit T Faligowska M Fedor-plenkowska G Gajos G Galicka-latala D Galuszka-bilinska A Gladysz I Grycewicz J Hachula G Janas I Jazwinska-tarnawska E Jedynasty K Jozefowska M Kaminska A Katra B Kitowska-koterla J Klupa T Koblik T Konduracka E Konieczny J Konieczny M Kosinski M Kulkowski G Kunecki M Kurmaniak M Lesniewski R Lominska T Losa B Majkowska D Malecki M Mirocka J Misztal M Mruk K Musialik K Olejniczak H Opadczuk P Peczynska J Plinta M Polaszewska-muszynska M Przech E Pupek-musialik D Ruzga Z Scibor Z Sidorowicz-bialynicka A Siegel A Stankiewicz A Strzelecka-sosik A Swierszcz T Szulinska M Szymkowiak K Trybul I Witek P Wozniak I Zambrzycki J Zarzycka-lindner G Zuradzka-wajda D Zurawska-klis M Ahn Hy Chin So Choi Sh Chon S Han Ka Jang Hc Jeong Kc Kang Sm Kim Jw Kim Hs Kim Sj Kim Sw Kim Ys Lee Ey Lim S Min Kw Nam Jy Oh Sj Park Sy Rhee Sy Shin Ja Son Ji Song Yd Woo Jt Yang Hk Yoo Js Yoon Jw Avram R Braicu Md Carlan L Catrinoiu D Ciomos D Ciorba A Ghise G Girgavu S Guja C Mihai D Nicodim S Nistor L Pintilei Dr Pintilei E Pletea N Pop A Rosu M Savu O Serban V Sima A Sitterli-natea C Suciu G Szabo M Szilagyi I Timar B Vlad A Vladu Im Alfaraj A Dubova V Dvoryashina I Gaysina L Gromova S Gudkova K Ivanova S Ivashkina I Kalashnikova M Kazankova T Khaykina E Khaykina O Kiseleva T Komissarova E Kononenko I Koreneva V Koshcheeva O Koshel L Kozachuk D Kufelkina T Kunitsyna M Likhodey N Lysenko T Makarova O Malceva A Mikhailova S Ogorodnikova E Pavlikova I Pekareva E Postoeva A Reshedko D Reshedko G Reshedko L Rogaleva A Rogova L Rozanov D Runov G Samylina I Semikina T Sergeeva-kondrachenko M Shatskaya O Shimokhina O Smetanina S Startseva M Strelkova A Suplotova L Suvorova L Sych Y Valeeva A Valeeva F Venjkova T Vinokurova V Voychik E Yanovskaya E Yanovskaya M Yarkova N Yarygina E Yuzhakova N Zakharova T Zanozina O Zenovko A Zhuk S Zhukova E Aleksic S Bulatovic A Buric B Cvijovic G Jelic Ma Jojic B Jotic A Kendereski A Lalic K Lukic L Macesic M Petkovic Mm Micic D Milicic T Popovic L Prostran M Rajkovic N Seferovic J Singh S Stojanovic R Stosic L Vuksanovic M Zamaklar M Zivkovic Tb Zoric S Aboo N Albertse Hw Badat A Basson M Bawa E Bester F Blignaut S Booysen S Bosch Fj Burgess L Cassimjee S Coetzee K Du Bois J Engelbrecht J Finegan K Gibson Gj Hansa S Hemus A Immink Ip Jacovides A Joshi P Joshi S Kapp C Khoelemachobane S Uys Knox Hj Kok J Komati S Lai E Lakha D Lehloenyane K Mahomed Ag Meeding R Moodley R Moosa N Nel J Nell H Van Niekerk Fj Omar M Pillay N Pretorius M Prozesky H Ramduth S Roos J Sarvan M Seeber M Siebert M Somasundram P Stavrides A Venter N Wadvalla S Alcolea Jo ÁLvarez De Arcaya Vicente A Pérez Arroyo Mb Romero Bobillo E Buño Mm Carreira Arias Jn Cepero García D Masmiquel Comas L Coves Figueras Mj De La Cuesta Mayor C Feria-carot Md Frade Fernández Am Ferreiro Gómez M García García C García Delgado E Durán García S Gómez Gómez La Soto González A Hernán García C ÁNgeles Tapia Herrero M Jodar Gimeno E Quevedo Juanals J López Jiménez M Masanes F Marco Mur ÁL Navarro López M Ramis Jn Palmer Ag Calle Pascual A Romero Pérez Lg Morales Portillo C Prieto González S Mezquita Raya P Reyes García R Vera Tr Rodríguez Castro C Rodríguez Rodríguez I Sacanella Meseguer E Serrano Olmedo I Lopez Soto A Toba Alonso F Aliaga Verdugo A Vidal Cortada J Vigil Medina L Ackefelt-frick E Alfredsson H Beling E Benedek P Crisby M Dorkhan M Drescik T Eeg-olofsson K Eliasson K Fardelin P Fredholm A Frid A Gerok-andersson K Hjelmaeus L Hufnagl A Jasinska E Kowalska E Lafolie P Lindquist O Lundvall M Melander E Nicander C Moris L Tengmark Bo Saphir U Skagerberg P Steczkó-nilsson C Strandell B Tomson Y Chen Jy Chen Yc Chiang Cy Chou Cw Ho Cw Hsiao Pj Hsieh Mc Hsu Rs Hsu Sr Huang Ch Hung Ww Lee My Lee Ym Lin Cw Lin Ch Lin Kd Lin Sd Lin Sf Liou Mj Lu Wt Shin Sj Sia Hk Su Mh Su Sl Sun Jh Tien Kj Tsai Dh Tsai Ss Tu St Wang Cc Wang Sy Yang Cy Yen Fc Acikgoz A Akalin S Akin S Akinci B Akkurt A Akturk M Alkis N Altun I Altunbas Ha Altuntas Y Araz M Aribas S Arslan E Arslan G Arslan M Ataoglu Eh Ayan F Aydin K Aydogan Bi Ayvaz G Bahadir Ma Balci Mk Basaran Mn Baskal N Bugra Mz Calan M Cavdar U Cetin F Cinar N Colbay M Dagdelen S Damci T Davutoglu V Demir M Demir T Deyneli O Dincer I Dogan B Kanipek Doker Ky Engin I Eraydin A Erbas T Erdogan Mf Ersoy C Gedik A Gokay F Gul Oo Guler S Gumus T Gunes E Gurler My Hatipoglu E Ilkova H Iyidir Ot Kabakci G Karadag B Karatemiz G Karci Ac Kartal E Kaya Eb Keskin C Keskin Ef Kocabas G Kocak F Kol Ak Korkmaz H Kucukler Fk Mesci Ba Oguz A Orbay E Oz H Ozcan Nd Ozdem S Ozisik S Ozkan C Ozsan M Ozyazar M Parlar H Sargin H Sargin M Saygili F Selek A Simsek Y Sisman P Solmaz K Soydas C Tatliagac S Tamer I Temizkan S Tulunay C Tuncel E Turker F Unluhizarci K Unluturk U Uygur Mm Vatansever B Yazici D Yavuz Dg Yener S Yenigun M Yilmaz M Abbas S Alawadi F Aziz Aa Bashier A Rashid F Abraham P Adamson K Atkin S Aye M Azam M Bain S Barnett Ah Bellary S Dhatariya K Eaton M English P Ewing J Furlong N Gibson M Green D Herring R Hordern V Jaap A Javed Z Johnson A Konya J Kumar S Lindsay R Mackie A Mcglynn S Mckenzie J Millward A Murthy N Paisey R Pearson E Piya M Ramell M Robertson D Russell-jones D Saravanan P Sathyapalan T Shakher J Shiels H Sivaraman S Smith J Srinivas-shankar U Stokes J Tracey I Vaidya B Yee M Yemparala P Walker J Wiggins P Williams J Wright J Mackinnon C Inkster J Zeeshan J Bejnariu C Malipatil N Giritharan S Lonnen K Kyrou I Aamir S Ababa M Abreu M Adams D Adams P Aden J Aguilar D Aguillon A Ahmed A Ahmed A Ahmed B Ahmed I Akhtar A Akright B Akright L Albarracin C Albert S Ali S Aliuddin B Almasmary A Al-maweri A Alzohaili O Amador W Amine M Amini S Anderson M Anderson L Anderson R Andrews M Angel J Anteer W Anthony V Antillon A Anzures P Arcon-rios S Arkin D Arodak B Aronne L Aronoff S Arreola G Arroyo S Asnani S Astudillo-tee G Ault S Austin B Avila V Avitabile N Awasty V Azar M Aziz A Bahrami P Baig M Bailey K Bailey T Baker M Bala Ns Balbes-reyes I Baldwin D Baldwin E Balentine T Ballard T Baloch K Banarer S Baney C Banka A Barber L Barber M Barker T Barnes K Barnum O Barra J Bartkowiak A Baula G Bautista A Bayliss R Beaman M Beatty K Becker J Bedolla L Begum G Belejchak P Bell A Beltran M Belucher C Bensfield E Benton J Bergamo K Bergman B Berry M Bettino K Beyea M Bhargava A Bhattacharya A Bilas A Bischoff L Bixler L Bizjack S Blank R Blankfield R Block L Bloodworth J Bloomberg K Bloomberg R Blustin J Boban I Bolden A Boncu O Bookless P Brassie C Brautigam D Bressler P Brewster R Brown C Brown C Brown D Brown F Bruskewitz M Bryant D Buchanan C Buchanan N Buck G Buckley S Bueno J Burke D Burton K Buske S Byars W Bye R Caldwell R Calvin K Camacho R Campbell E Cannon D Cantrell J Caplan J Cardenas C Carlton J Carpio G Carrol A Cartwright L Casanova G Castaneda L Castle M Castro L Catangay J Chaidarun S Chambers J Chambliss T Chandra L Chang A Chang S Chappel J Chappel C Chappell T Charles C Chavira A Chaykin L Check E Chee L Chen J Cherry A Chestnut A Chiarot J Chiniwala N Chionh K Choe J Christiansen M Chrzanowski S Chuang E Chuck L Clyatt J Cohan B Cohen R Comi R Comulada-rivera A Conner K Connor G Contreras R Cook K Cook R Cook R Corder C Cornejo B Sr Cornette L Cortes G Cortez L Cox C Cox G Craig W Cramer B Cromer C Cromer M Cuddihy R Culmer D Curran H Curran M Dadis C Dagogo-jack S Dairywala I D'alessio D Damberg G Dang A Daniel K Davidson M Davis T Dean J Debold R Deitz P Del M Delaney D Delgado E Demicco M Demuro Ma Desalle D Desouza C Devireddy K Devries B Dezube M Diab I Diesburg-stanwood A Dilliard J Dilling J Diner J Dishongh K Dodis R Doing C Doll W Donoho A Donovan D Doremus N Dorfman S Doshi P Dostou J Douglas D Douglass S Douglas D Dowell M Drazich E Driver E Du H Dubose R Iii Duclos M Dunn K Dunnam T Durham N Dye L Eagerton D Ebenibo S Edeoga C Edwards G Ekwensi J El Asmar I El Sayad N Eliopoulos C Elkosseifi M Elmer R Elmore M Elson D Elzein L Emmert L Erbe L Estes S Estrada L Estrada A Eveleigh T Everhart B Faas F Faircloth C Farmer M Fehr K Ferguson T Fernandes J Ferree K Ferrington B Fitzhugh M Fitzsimmons R Flanders D Flores M Flores E Flores J Florida C Flynn J Folmar P Forbes R Ford W Fowler M Fraker A Francis S Franco-cotto E Fratila C Fuentes M Galagan R Galloway A Garcia M Garcia R Garriott M Garza J Gass N Gates S Gates S Geary M Geiger K Geishauser J Giglio A Gilbert M Godwin S Goetter B Goley A Golici L Gomori E Gonzales J Gore A Gorman T Gosmanova A Goswami K Gotham A Govoni J Graddick S Grant T Greca A Green C Greenbaum K Greenwald J Grover D Grunberger G Guice M Guirao D Gunna V Guseva N Ha T Hagan A Hager S Haggag A Haggar M Hamilton M Hamilton M Hamlet P Hammond J Hansen A Harrell W Harris E Harris K Harris M Harrison L Hartman I Hatch A Hayes D Hayes M Heath J Heineman R Heinzman A Hendrick M Herbst R Hermayer K Hibbard J Hill Wd Hilliard B Hix M Hoch B Hollander P Holmes Z Horobetz C Horowitz R Hsieh P Hsieh S Htun W Huang J Huber C Hudson T Huizar S Hull B Hull J Hummer K Hundal R Hunt G Hunt V Hutchinson P Hwang J Iannamorelli A Iannuzzi L Ingram M Iram N Ismail-beigi F Jabbour S Jackson T Jaen L Jain V Jannesari R Januski V Japa U Jarvis K Jayson L Jensen R Jester D Jocko C Johnson C Johnson M Johnson M Johnston K Jones D Jones J Jordan T Juarez M Kaapuraala A Kain A Kaiser V Kamradt K Karatoprakli P Karegar M Karounos C Karounos D Karunaratne H Katalenich B Katic K Katz M Kaur G Kawa A Keib C Keider G Kem D Kennedy R Kenney B Kereiakes D Ketana M Kettinger L Khaira A Khan A Khan K Khan M Khan M Khoo T Khrlobyan N Kilgore J Kim G Kimble S Kinsley M Kitchen T Klick M Kniffen W Knight R Kodzwa D Koenig T Komarovskiy K Kong Y Koontz D Krishnasamy S Krueger E Kuechenmeister L Kuehl A Kuettel K Kugler D Kulow T Kupriyanchik I Kuruvanka T Kushner D Kwon E Kwon S Kyle M Labryer L Labuda J Lafave J Laguerre J Laliberte A Lane J Langel C Lann D Largay J Latif K Latus T Lawrence J Ledger G Lee Fg Lee E Leffert J Leinung M Lenhard Mj Lentino J Leon J Leonard M Letassy N Leuck K Levin P Levinson D Lewis M Light T Lim J Lindamood R Lingvay I Lipps J Lisa A Livingston Y Llamas L Loesch R Long T Looby R Lopez C Lorenz T Lovre D Lu P Lucas K Luevano G Luidens M Luna B Luttrell L Lyons T Macadams M Macadams M Mack D Mack M Madden M Madder R Madireddy S Mae L Mahakala A Maheshwari H Malbari H Maldonado N Mallitz M Mandviwala M Mann K Mardahay M Marino J Marney A Marshall L Martin A Martin E Martinez G Martinez G Martinez-miss S Marx P Massara L Mastoor M Matfin G Maturu A Maurides P May M Mayfield R Maynard B Mazza A Mccann K Mccoy J Mccoy T Mccullen Mk Mcdaniel C Mcdaniel Am Mcdermott M Mcdonald A Mcdonald C Mcmasters B Mcmurray C Medlin T Meinel M Mendez I Menefee J Meredith M Merriweather M Mersey J Messino C Meyer S Meyers L Michael D Midyett C Miklius A Milford E Miller B Miller H Milligan M Minor A Miranda-palma B Mirarchi N Mittadodla S Mittle J Moffat A Mohaupt S Mohiuddin K Mokshagundam S Monaco S Monsaert R Montano-pereira C Montgomery A Moody K Moon M Moore D Moore L Morawski E Moreau C Morin D Moscoa C Motzkin C Mueller R Munoz C Munoz M Myneni A Naderi B Nagireddy P Naidu J Naidu R Naik S Naimark R Nardicchi M Ndukwu I Neller C Netten-foster L Neumiller J New T Newman S Newton T Nguyen B Nicol B Nicol P Ninivaggi L Niswender K Norman L Noworatzky G Nyenwe E O'brien H O'connell T Oden W Odugbesan A Oliver M Oliver T Olmeda C O'neil C Oremus R Ortega T Ortiz-santos S Osborn T Padmanabhan S Papacostea O Park I Parker A Parker K Parker R Patel C Patel M Patel R Patel R Patino M Patterson S Paulson K Paz A Pemba R Pepe C Perez J Perez T Perry D Phillips B Phillips J Pickett A Pinson M Pitzer R Poduri M Poehls J Poteat T Powell L Prasad S Prevost J Price E Priest D Prieto L Purewal T Purighalla R Purighalla U Quadrel M Qureshi A Radhamma R Rafla E Rajab H Ramalingam R Ramirez A Ramirez J Ramirez K Ramirez M Randall M Rangaraj U Rao V Rasmussen P Rasouli N Ray A Ray S Reed J Rems L Renaud K Reno M Resnick M Reusch J Reynolds L Rhoton K Rhudy J Ricci C Rice L Richardson A Richardson L Rickard H Rickels M Riff D Rightenour N Risser J Rizvi A Rizvi A Robertson J Robinson A Robinson R Rockwell M Rodriguez Jp Rodriguez M Rojas M Rojas W Rooker-morris L Root C Rose M Rosenberg R Rosenstock J Roth M Ruby R Sachson R Sack P Sadler Rk Sahai S Salazar J Salgam M Samal A Samson A Sanagorski R Sanchez A Sandberg J Sanderson M Sandoval J Santiago E Sapp T Saunders J Schill J Schott C Schreiman R Schu D Schuh K Schutta M Schwartz J Schweppe L Scofield H Scribner A Seal J Sealock J Seaton B Sedlak-hanslik T Seekins K Segal M Seggelke S Semenza S Sentman P Serra M Seshadri P Sevilla E Shah S Shaheen K Shanik M Shaw J Sheets M Shellabarger C Sher J Shippey J Shivaswamy V Shomali M Shore D Shroff P Siddiqui T Siegwald A Silver R Simmons D Simons R Sinan A Singh M Sirinvaravong S Skero J Slover-zipf J Small S Smith B Smith K Smith M Sohl J Solarz Sh Soler D Sood A Sora N Souchet A Soule J Sparks J Spector L Speicher R Spillers L Spivey T Springer N Sprouse H St John J Stacey A Stacey H Stafford M Stagner E Staples K Steadman E Steed R Steeves G Steinberg H Stell C Stirman E Straub K Strock E Sue M Suris O Sutton T Tabbah I Talsania M Tang R Tapia J Taylor K Taylor-hancher R Teator R Tekateka M Temple B Temple K Teodori M Tharp P Thethi T Theuma P Thomas S Thottan A Thrasher J Thrasher L Tiemeyer M Tinney I Tobin T Toma S Tovar M Townsend J Trantow C Traylor H Trevino M Troy M Trumper D Tryggestad J Tucker C Turner J Turney R Tuten C Tyzack J Ullo L Underkofler C Unger J Urdanetta R Valdivia V Valenti S Vanderheiden A Vanderlinde-wood M Varma C Vasquez E Vazquez M Vickery D Villafuerte B Villegas C Vivar J Vivekananthan K Vo G Vukojicic K Wachter A Wahl D Waitmann J Walker D Walsh J Walsh K Walton A Wang A Wardell K Warren M Watkins S Watkinson J Watts M Watwe V Weaver N Weber R Wedick C Weeks D Weeks L Weindorff K Weinstein R Weiss S Wenger K Wentworth M Werner A West M Whelan S White B White J Whitmire M Whittington R Wical J Wigley C Wilkins F Will K Williams A Wilson Le Wince M Wine S Winkle P Winner C Wise J Witte M Wittenmyer J Wood C Wood R Woodruff C Worthington B Wynn D Wysham C Xavier P Yela S Yenoby L Young L Younus N Yourell V Zaid M Zubair I.

subject

Male Settore MED/09 - Medicina Interna Acute Kidney Injury; Aged; Albuminuria; Creatinine; Diabetes Mellitus Type 2; Diabetic Nephropathies; Double-Blind Method; Female; Follow-Up Studies; Glomerular Filtration Rate; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Intention to Treat Analysis; Kidney Failure Chronic; Liraglutide; Male; Middle Aged Type 2 diabetes 030204 cardiovascular system & hematology urologic and male genital diseases GLOMERULAR-FILTRATION-RATE KIDNEY-FUNCTION DISEASE law.invention Kidney Failure chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial Glucagon-Like Peptide 1 law Medicine Diabetic Nephropathies Hypoglycemic Agents.Settore MED/49 - Scienze Tecniche Dietetiche Applicate Chronic RISK Kidney Acute kidney injury 11 Medical And Health Sciences General Medicine Acute Kidney Injury Middle Aged Intention to Treat Analysis medicine.anatomical_structure Creatinine TRIAL Female liraglutide randomized controlled trial type 2 diabetes renal outcomes Life Sciences & Biomedicine Type 2 Glomerular Filtration Rate medicine.drug medicine.medical_specialty Renal function 030209 endocrinology & metabolism CARDIOVASCULAR OUTCOMES Follow-Up Studie 03 medical and health sciences Medicine General & Internal Double-Blind Method General & Internal Medicine Diabetes mellitus Internal medicine Diabetes Mellitus Albuminuria Humans Hypoglycemic Agents Intensive care medicine Aged Creatinine Science & Technology business.industry Liraglutide MORTALITY Liraglutide medicine.disease INTENSIVE GLUCOSE CONTROL INDIVIDUALS Diabetes Mellitus Type 2 chemistry Diabetic Nephropathie Kidney Failure Chronic LEADER Steering Committee and Investigators business Follow-Up Studies

description

BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary end point (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes) and death. However, the long-term effects of liraglutide on renal outcomes in patients with type 2 diabetes are unknown. METHODS: We report the prespecified secondary renal outcomes of that randomized, controlled trial in which patients were assigned to receive liraglutide or placebo. The secondary renal outcome was a composite of new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal disease, or death due to renal disease. The risk of renal outcomes was determined with the use of time-to-event analyses with an intention-to-treat approach. Changes in the estimated glomerular filtration rate and albuminuria were also analyzed. RESULTS: A total of 9340 patients underwent randomization, and the median follow-up of the patients was 3.84 years. The renal outcome occurred in fewer participants in the liraglutide group than in the placebo group (268 of 4668 patients vs. 337 of 4672; hazard ratio, 0.78; 95% confidence interval [CI], 0.67 to 0.92; P=0.003). This result was driven primarily by the new onset of persistent macroalbuminuria, which occurred in fewer participants in the liraglutide group than in the placebo group (161 vs. 215 patients; hazard ratio, 0.74; 95% CI, 0.60 to 0.91; P=0.004). The rates of renal adverse events were similar in the liraglutide group and the placebo group (15.1 events and 16.5 events per 1000 patient-years), including the rate of acute kidney injury (7.1 and 6.2 events per 1000 patient-years, respectively). CONCLUSIONS: This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo. (Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .).

year	journal	country	edition	language
2017-08-31

10.1056/nejmoa1616011 http://hdl.handle.net/11585/619768