0000000000236074
AUTHOR
Ina Bergheim
showing 8 related works from this author
Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD)
2020
(1) Background: The etiology of non-alcoholic fatty liver disease (NAFLD) is multifactorial. Dietary composition has been implicated as a factor modulating intestinal barrier and could affect disease severity. The aim of this study was to evaluate dietary intake and markers of intestinal permeability in patients with NAFLD. (2) Methods: We enrolled 63 patients with NAFLD and compared them to age-matched controls. (3) Results: body mass index (BMI) and leptin to adiponectin ratio&mdash
P-14ROLE OF TUMOR NECROSIS FACTOR ALPHA IN THE REGULATION OF ALCOHOL DEHYDROGENASE ACTIVITY IN THE LIVER: STUDIES IN OB/OB MICE
2015
Studies suggest that the activity of hepatic ADH is regulated at least in parts by gender, age and body weight. It further has been shown that hormones but also insulin signaling pathways may be involved in ADH activity. However, molecular mechanisms have not yet been fully understood. The aim …
Microbiome and Diseases: Hepatic Disorders
2018
Intensive research efforts aim to understand the multifaceted molecular mechanisms underlying disease onset and progression of nonalcoholic fatty liver disease (NAFLD) and alcohol-induced liver disease (ALD). Taken together, NAFLD and ALD are the most common liver diseases worldwide, and universally accepted therapies other than lifestyle interventions either focusing on weight reduction and physical exercise or alcohol abstinence are lacking. During the last decade, alterations of intestinal microbiota composition and intestinal barrier function leading to an increased translocation of bacterial endotoxin and of metabolites originating from an altered intestinal microbiome are emerging as …
Nutritional Intake and the Risk for Non-Alcoholic Fatty Liver Disease (NAFLD)
2019
The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising worldwide, and it is estimated that approximately one billion individuals may be afflicted with NAFLD globally [...]
Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors
2014
Apoptosis signaling is involved in both physiological tissue homeostasis and acute and chronic diseases. The role of regulatory apoptosis signaling molecules and their organ-specific functions are less defined. Therefore, we investigated the loss of the anti-apoptotic cellular FLICE-inhibitory protein (cFLIP) and the mechanisms of the resulting lethal organ failure in vivo using inducible knockout mice. These were generated by crossing floxed cFLIP mice to a tamoxifen inducible Rosa26-creERT2 mouse strain. Death following global loss of cFLIP resulted from liver failure, accumulation of M1-polarized macrophages and accompanying hepatic cell death and inflammation. Apoptosis was also promine…
Fruktose – Freund oder Feind?
2016
Die Aufnahme von Fruktose ist in vielen industrialisierten Landern weltweit in den letzten Jahrzehnten stark angestiegen. Dies resultiert u. a. aus einer zunehmenden Verwendung des reinen Monosaccharids oder des sog. „High Fructose Corn Syrup“ (HFCS, Maissirup oder auch Fruktose-Glukose-Sirup) als Susungsmittel. Neben Problemen fur Patienten mit einer angeborenen oder erworbenen Fruktosemalabsorption sowie der seltenen, genetisch bedingten hereditaren Fruktoseintoleranz, wird die vermehrte industrielle Verwendung und die damit einhergehende vermehrte Aufnahme von Fruktose uber die Nahrung als ein Risikofaktor in der Entstehung von Ubergewicht und damit assoziierten metabolischen Erkrankunge…
Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease
2015
Objective Increased fasting blood ethanol levels, suggested to stem from an increased endogenous ethanol synthesis in the GI tract, are discussed to be critical in the development of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to further delineate the mechanisms involved in the elevated blood ethanol levels found in patients with NAFLD. Design In 20 nutritionally and metabolically screened children displaying early signs of NAFLD and 29 controls (aged 5–8 years), ethanol plasma levels were assessed. Ethanol levels along the GI tract, in vena cava and portal vein, intestinal and faecal microbiota, and activity of alcohol dehydrogenase (ADH) and cytochrome P450…
Voluntary distance running prevents TNF-mediated liver injury in mice through alterations of the intrahepatic immune milieu
2017
AbstractPhysical activity confers a broad spectrum of health benefits. Beyond the obvious role in metabolically driven diseases, the role of physical activity in acute liver injury is poorly explored. To study the role of physical activity in acute liver injury, a novel model of voluntary distance running in mice was developed and mice were subjected to acute liver injury induced by N-galactosamine (GalN) and lipopolysaccharide (LPS). Analyses included histological stains, immunoblotting, qRT-PCR and FACS analysis. Voluntary distance running increased to an average of 10.3 km/day after a learning curve. Running lead to a decrease in the absolute numbers of intrahepatic CD4+ T and B lymphocy…