Antiviral treatment in patients with indolent B-cell lymphomas associated with HCV infection: a study of the Fondazione Italiana Linfomi

Tailoring Electrospinning Fabrication for Scaffolds for Heart Valve Tissue Engineering

Previous work in controlling mechanical properties of electrospun scaffolds has largely been limited to altering the orientation of the fibrous network by either large rotational velocity or by altering the electric field during fabrication. Our lab has previously developed a technique to analyze the complete microstructural topology of electrospun scaffolds and extract key descriptors. In this project, we translated the target mandrel at varying speeds along its rotational axis in order to modify the microarchitecture without altering the fiber orientation angle. Using the algorithm mentioned above, we determined that increasing the translation speed resulted in a decrease in fiber interse…

Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Abstract: Background Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods Th…

Population Properties of Compact Objects from the Second LIGO-Virgo Gravitational-Wave Transient Catalog

Abbott, R., et al. (LIGO and Virgo Collaboration)

A microstructure based mechanical model for planar fibrous scaffolds.

Cardiac valve and myocardium tissue regeneration has consistently raised interest for cell-seeded/microintegrated planar fibrous scaffolds. Electrospun constructs, decellularized tissues and collagen/fibrin gels often show a similar microstructure mainly characterized by the fibrous network topology. Microstructure based mechanical modeling enable fabrication parameters and scaffolds morphology to be related to mesomacro mechanical response. A novel approach to (1) characterize the material fibers network microarchitecture, (2) reproduce stochastically equivalent fiber network models, and (3) predict the mechanical response at meso-macro level is presented in this work. Electron micrographs…

High prevalence of BRCA1 deletions in BRCAPRO-positive patients with high carrier probability.

Mutation screening of the BRCA1 and BRCA2 genes in probands with familial breast/ovarian cancer has been greatly improved by the multiplex ligation-dependent probe amplification (MLPA) assay able to evidence gene rearrangements not detectable by standard screening methods. However, no criteria for selection of cases to be submitted to the MLPA test have been reported yet. We used the BRCAPro software for the selection of familial breast/ovarian cancer probands investigated with the MLPA approach after negative BRCA1/2 conventional mutation screening. One hundred and seventy-seven probands were investigated for germline BRCA1/2 mutations after assessment of genetic risk using BRCAPro. Proban…

Search for gamma ray bursts with the ARGO-YBJ detector in scaler mode

We report on the search for Gamma Ray Bursts (GRBs) in the energy range 1-100 GeV in coincidence with the prompt emission detected by satellites using the Astrophysical Radiation with Ground-based Observatory at YangBaJing (ARGO-YBJ) air shower detector. Thanks to its mountain location (Yangbajing, Tibet, P.R. China, 4300 m a.s.l.), active surface (about 6700 m**2 of Resistive Plate Chambers), and large field of view (about 2 sr, limited only by the atmospheric absorption), the ARGO-YBJ air shower detector is particularly suitable for the detection of unpredictable and short duration events such as GRBs. The search is carried out using the "single particle technique", i.e. counting all the …

The ARGO-YBJ experiment in Tibet

The setting up of the ARGO detector at the YangBaJing Cosmic Ray Laboratory (4300 m a.s.l., Tibet, P.R. China) has been completed during the last spring (2007). It consists of a central carpet made of 130 identical sub-units of 12 RPCs each (a "cluster"), covering a surface of about 5800 m2 with 93% active area, and a guard ring of 24 further clusters of the same type surrounding the central carpet with a lower sampling density. Signals are picked up by external electrodes of small size, thus allowing the sampling of EAS with high space-time granularity. Shower events are detected at a trigger rate of about 4 kHz. Events with a few particles detected by a single cluster are counted in scale…

Upper limits on the isotropic gravitational-wave background from Advanced LIGO and Advanced Virgo's third observing run

We report results of a search for an isotropic gravitational-wave background (GWB) using data from Advanced LIGO's and Advanced Virgo's third observing run (O3) combined with upper limits from the earlier O1 and O2 runs. Unlike in previous observing runs in the advanced detector era, we include Virgo in the search for the GWB. The results are consistent with uncorrelated noise, and therefore we place upper limits on the strength of the GWB. We find that the dimensionless energy density $\Omega_{\rm GW}\leq 5.8\times 10^{-9}$ at the 95% credible level for a flat (frequency-independent) GWB, using a prior which is uniform in the log of the strength of the GWB, with 99% of the sensitivity comi…

Constraints on Cosmic Strings Using Data from the Third Advanced LIGO–Virgo Observing Run

We search for gravitational-wave signals produced by cosmic strings in the Advanced LIGO and Virgo full O3 data set. Search results are presented for gravitational waves produced by cosmic string loop features such as cusps, kinks and, for the first time, kink-kink collisions.cA template-based search for short-duration transient signals does not yield a detection. We also use the stochastic gravitational-wave background energy density upper limits derived from the O3 data to constrain the cosmic string tension, $G\mu$, as a function of the number of kinks, or the number of cusps, for two cosmic string loop distribution models.cAdditionally, we develop and test a third model which interpolat…

Diving below the spin-down limit: Constraints on gravitational waves from the energetic young pulsar PSR J0537-6910

We present a search for continuous gravitational-wave signals from the young, energetic X-ray pulsar PSR J0537-6910 using data from the second and third observing runs of LIGO and Virgo. The search is enabled by a contemporaneous timing ephemeris obtained using NICER data. The NICER ephemeris has also been extended through 2020 October and includes three new glitches. PSR J0537-6910 has the largest spin-down luminosity of any pulsar and is highly active with regards to glitches. Analyses of its long-term and inter-glitch braking indices provided intriguing evidence that its spin-down energy budget may include gravitational-wave emission from a time-varying mass quadrupole moment. Its 62 Hz …

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