0000000001134988

AUTHOR

Castellino Pietro

showing 8 related works from this author

Impact of Diabetes Mellitus and Its Comorbidities on Elderly Patients Hospitalized in Internal Medicine Wards: Data from the RePoSi Registry

2022

Background: Currently, diabetes represents the seventh leading cause of death worldwide, with a significant economic burden. The number and severity of comorbidities increase with age, and are identified as important determinants that influence the prognosis. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients affected by diabetes. Methods: In this observational study, we retrospectively analyzed data collected from the REgistro dei pazienti per lo studio delle POlipatologie e politerapie in reparti della rete Simi (RePoSi) registry. Socio-demographic, clinical characteristics, and laboratory findings were considered. The association between varia…

Leadership and Management1-year mortality cancer comorbidities diabetes heart rate in-hospital mortality male sex.Heart rateSocio-culturaleHealth InformaticscomorbiditiesArticleComorbiditiesHealth Information Managementdiabetes; comorbidities; heart rate; cancer; male sex; in-hospital mortality; 1-year mortalityheart ratecancer1-year mortality; Cancer; Comorbidities; Diabetes; Heart rate; In-hospital mortality; Male sexLS4_4Cancerdiabetesmale sexHealth PolicyDiabetesRMale sexIn-hospital mortality1-year mortalityMedicine1-year mortality Cancer Comorbidities Diabetes Heart rate In-hospital mortality Malein-hospital mortality
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Hyperglycemia at admission, comorbidities, and in-hospital mortality in elderly patients hospitalized in internal medicine wards: data from the RePoS…

2021

Abstract Aims The association between hyperglycemia at hospital admission and relevant short- and long-term outcomes in elderly population is known. We assessed the effects on mortality of hyperglycemia, disability, and multimorbidity at admission in internal medicine ward in patients aged ≥ 65 years. Methods Data were collected from an active register of 102 internal medicine and geriatric wards in Italy (RePoSi project). Patients were recruited during four index weeks of a year. Socio-demographic data, reason for hospitalization, diagnoses, treatment, severity and comorbidity indexes (Cumulative Illness rating Scale CIRS-SI and CIRS-CI), renal function, functional (Barthel Index), and cog…

RegistrieMaleComorbidity; Diabetes; Disability; Elderly; Hyperglycemia; Mortality; Aged; Aged 80 and over; Comorbidity; Female; Hospital Mortality; Hospitals; Humans; Internal Medicine; Male; Registries; Hospitalization; Hyperglycemiamedicine.medical_specialtyEndocrinology Diabetes and MetabolismSocio-culturaleRenal functionComorbidity; Diabetes; Disability; Elderly; Hyperglycemia; MortalityComorbidity030204 cardiovascular system & hematologyDiabeteHospital03 medical and health sciences0302 clinical medicineEndocrinologyElderlyRating scaleInternal medicineDiabetes mellitus80 and overInternal MedicinemedicineHumansLS4_4Hospital MortalityRegistries030212 general & internal medicineMortalityAgedAged 80 and overDisabilityClass III obesitybusiness.industryMortality rateDiabetesComorbidity Diabetes Disability Elderly Hyperglycemia MortalityGeneral Medicinemedicine.diseaseComorbidityHospitalsHospitalizationMood disordersHyperglycemiaMortality.FemaleGeriatric Depression ScaleOriginal ArticlebusinessHumanActa Diabetologica
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Pain and Frailty in Hospitalized Older Adults

2020

Introduction Pain and frailty are prevalent conditions in the older population. Many chronic diseases are likely involved in their origin, and both have a negative impact on quality of life. However, few studies have analysed their association. Methods In light of this knowledge gap, 3577 acutely hospitalized patients 65 years or older enrolled in the REPOSI register, an Italian network of internal medicine and geriatric hospital wards, were assessed to calculate the frailty index (FI). The impact of pain and some of its characteristics on the degree of frailty was evaluated using an ordinal logistic regression model after adjusting for age and gender. Results The prevalence of pain was 24.…

medicine.medical_specialtyPain medicineSocio-culturaleChronic painOsteoarthritisAffect (psychology)Chronic pain; Internal medicine and geriatric wards; Musculoskeletal diseasesOlder populationChronic pain Internal medicine and geriatric wards Musculoskeletal diseasesQuality of lifeMusculoskeletal diseaseInternal medicine and geriatric wardsAnesthesiologyInternal medicinemedicineRD78.3-87.3LS4_4Original Researchbusiness.industryMusculoskeletal diseasesChronic painmedicine.diseaseInternal medicine and geriatric wardMusculoskeletal diseases.Anesthesiology and Pain MedicineRheumatoid arthritisNeurology (clinical)Ordered logitbusiness
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Frequency of Left Ventricular Hypertrophy in Non-Valvular Atrial Fibrillation

2015

Left ventricular hypertrophy (LVH) is significantly related to adverse clinical outcomes in patients at high risk of cardiovascular events. In patients with atrial fibrillation (AF), data on LVH, that is, prevalence and determinants, are inconsistent mainly because of different definitions and heterogeneity of study populations. We determined echocardiographic-based LVH prevalence and clinical factors independently associated with its development in a prospective cohort of patients with non-valvular (NV) AF. From the "Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study" (ARAPACIS) population, 1,184 patients with NVAF (mean age 72 ± 11 yea…

RegistrieMaleCross-sectional studyMyocardial InfarctionLongitudinal StudieLeft ventricular hypertrophyCohort Studiesnon-valvular atrial fibrillationAtrial Fibrillation80 and overPrevalenceechocardiographyMyocardial infarctionLongitudinal StudiesProspective StudiesRegistriesProspective cohort studyUltrasonographyAged 80 and overeducation.field_of_studyMedicine (all)Atrial fibrillationDiabetes MellituMiddle AgedLeft Ventricularleft ventricular hypertrophyItalyHypertensionCardiologyAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries; Cardiology and Cardiovascular Medicine; Medicine (all)Hypertrophy Left VentricularFemaleCardiology and Cardiovascular MedicineHumanmedicine.medical_specialtyLogistic ModelPopulationConcentric hypertrophySocio-culturalenon-valvular atrial fibrillation left ventricular hypertrophy echocardiography cardiovascular diseasesPeripheral Arterial DiseaseAge DistributionInternal medicinemedicineDiabetes MellitusHumansAnkle Brachial Indexcardiovascular diseaseseducationAgedCross-Sectional Studiebusiness.industryAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries; Cardiology and Cardiovascular MedicineOdds ratioHypertrophymedicine.diseasecardiovascular diseasesProspective StudieCross-Sectional StudiesLogistic ModelsCohort StudiebusinessAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries
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Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients

2023

Background: Hypertension management in older patients represents a challenge, particularly when hospitalized. Objective: The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients. Methods: A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian in-patients from internal medicine or geriatric wards) were considered; 4377 (77.2%) were hypertensive. Minimum treatment (MT) for hypertension was defined according to the 2018 ESC guidelines [an angiotensin-converting-enzyme-inhibitor (ACE-I) or an angiotensin-receptor-blocker (ARB) with a calciu…

cardiovascular eventsolder patienthypertensionantihypertensive drugs; cardiovascular events; hypertension; older patients; survivalantihypertensive drugsClinical Biochemistryantihypertensive drugGeneral Medicinesurvival.Biochemistrycardiovascular eventolder patientssurvival
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Pattern of in-hospital changes in drug use in the older people from 2010 to 2016

2017

Purpose: To assess the pattern of in-hospital changes in drug use in older patients from 2010 to 2016. Methods: People aged 65 years or more acutely hospitalized in those internal medicine and geriatric wards that did continuously participate to the REgistro POliterapie Società Italiana di Medicina Interna register from 2010 to 2016 were selected. Drugs use were categorized as 0 to 1 drug (very low drug use), 2 to 4 drugs (low drug use), 5 to 9 drugs (polypharmacy), and 10 or more drugs (excessive polypharmacy). To assess whether or not prevalence of patients in relation to drug use distribution changed overtime, adjusted prevalence ratios (PRs) was estimated with log-binomial regression mo…

RegistrieMalepharmacoepidemiologyEpidemiologyDischarged alive030204 cardiovascular system & hematologyinternal medicine and geriatric warddrug use; excessive polypharmacy; internal medicine and geriatric wards; older people; pharmacoepidemiology; polypharmacyexcessive polypharmacyolder people0302 clinical medicineDrug PrescriptionRisk Factors80 and overPharmacology (medical)030212 general & internal medicineRegistriesAt-Risk Populationmedia_commonAged 80 and overOvertimedrug use excessive polypharmacy internal medicine and geriatric wards older people pharmacoepidemiology polypharmacyinternal medicine and geriatric wardsPharmacoepidemiologyHospitalizationItalyFemaleMedical emergencyHumanDrugmedicine.medical_specialtymedia_common.quotation_subjectSocio-culturaleDrug Prescriptions03 medical and health sciencesHospital dischargemedicineInternal MedicineHumanspolypharmacyAgeddrug usePolypharmacyInpatientsbusiness.industryRisk Factormedicine.diseasedrug use; excessive polypharmacy; internal medicine and geriatric wards; older people; pharmacoepidemiology; polypharmacy; Aged; Aged 80 and over; Drug Prescriptions; Female; Hospitalization; Humans; Internal Medicine; Italy; Male; Polypharmacy; Registries; Risk Factors; InpatientsEmergency medicinePolypharmacyOlder peoplebusiness
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Kidney Disease Management in the Hospital Setting: A Focus on Inappropriate Drug Prescriptions in Older Patients

2021

Aging with multimorbidity and polytherapy are the most significant factors that could led to inappropriate prescribing of contraindicated medications in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the prescriptions of contraindicated drugs in older adults in CKD and to identify their associated factors in a hospital context. An observational retrospective study was carried out considering all patients ≥65 years with at least one serum creatinine value recorded into the REPOSI register into 2010–2016 period. The estimated glomerular filtration rate (eGFR) was applied to identify CKD. A descriptive analysis was performed to compare demographic and clinica…

medicine.medical_specialtyappropriateness of prescriptionprescribing patternsRenal functionContext (language use)RM1-950Logistic regressionNOchemistry.chemical_compoundolder patientInternal medicinehospital settingmedicinePharmacology (medical)LS4_4Medical prescriptionprescribing patternappropriateness of prescriptions chronic kidney disease hospital setting older patients prescribing patterns real-world data.Original ResearchPharmacologyCreatininereal-world databusiness.industryRetrospective cohort studymedicine.diseaseolder patientsreal-world data.appropriateness of prescriptions; chronic kidney disease; hospital setting; older patients; prescribing patterns; real-world dataappropriateness of prescriptionschemistryObservational studyTherapeutics. Pharmacologybusinesschronic kidney diseaseKidney diseaseFrontiers in Pharmacology
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Implementation of the Frailty Index in hospitalized older patients: Results from the REPOSI register

2018

Abstract Background Frailty is a state of increased vulnerability to stressors, associated to poor health outcomes. The aim of this study was to design and introduce a Frailty Index (FI; according to the age-related accumulation of deficit model) in a large cohort of hospitalized older persons, in order to benefit from its capacity to comprehensively weight the risk profile of the individual. Methods Patients aged 65 and older enrolled in the REPOSI register from 2010 to 2016 were considered in the present analyses. Variables recorded at the hospital admission (including socio-demographic, physical, cognitive, functional and clinical factors) were used to compute the FI. The prognostic impa…

GerontologyMaleMultivariate analysisFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Internal MedicinePhysical and cognitive impairmentPsychological interventionPredictive Value of TestSeverity of Illness Index0302 clinical medicineInternal medicine and geriatric wardsInterquartile rangeFrailty Internal medicine and geriatric wards Multimorbidity Physical and cognitive impairment80 and overMedicine030212 general & internal medicineProspective StudiesHospital MortalityProspective cohort studyMultivariate AnalysiAged 80 and overFrailtyPrognosisFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Aged; Aged 80 and over; Female; Frailty; Geriatric Assessment; Hospitalization; Humans; Italy; Male; Multimorbidity; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Regression Analysis; Survival Analysis; Frail Elderly; Hospital Mortality; Severity of Illness IndexHospitalizationItalyPredictive value of testsRegression AnalysisFemaleSurvival AnalysiCohort studyHumanPrognosiFrail ElderlyFrailty; Internal medicine and geriatric wards; Multimorbidity; Physical and cognitive impairment; Aged; Aged 80 and over; Female; Frailty; Geriatric Assessment; Hospitalization; Humans; Italy; Male; Multimorbidity; Multivariate Analysis; Predictive Value of Tests; Prognosis; Prospective Studies; Regression Analysis; Survival Analysis; Frail Elderly; Hospital Mortality; Severity of Illness Index; Internal MedicineSocio-culturaleRegression Analysi03 medical and health sciencesPredictive Value of TestsSeverity of illnessInternal MedicineHumansGeriatric AssessmentSurvival analysisAgedbusiness.industryMultimorbiditySurvival AnalysisInternal medicine and geriatric wardProspective StudieMultivariate Analysisbusiness030217 neurology & neurosurgery
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