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RESEARCH PRODUCT

Occupational UV-Exposure is a Major Risk Factor for Basal Cell Carcinoma

Thomas L. DiepgenWilliam GrobeStephan WesterhausenI. BruhnThoralf StangeJean Pierre AllamKlaus BachmannThomas BrüningFreya TrautmannAndreas SeidlerBerenice Mareen LangPeter KnuschkeWobbeke WeistenhöferMarc WittlichHans DrexlerJochen SchmittAndrea BauerSonja BonnessSusanne Dugas-breitE. HaufeHans-joachim SchulzeMichal GinaManigé FartaschStephan LetzelSwen Malte JohnPeter Elsner

subject

AdultMaleOncologymedicine.medical_specialtySkin NeoplasmsUltraviolet RaysPopulationPopulation basedRadiation Dosage030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineRisk FactorsOccupational ExposureInternal medicineOdds RatiomedicineCarcinomaHumansBasal cell carcinomaRisk factorPropensity Scoreskin and connective tissue diseaseseducationAgedAged 80 and overeducation.field_of_studyintegumentary systembusiness.industryfungiPublic Health Environmental and Occupational HealthCase-control studyDose-Response Relationship RadiationOdds ratioMiddle Agedmedicine.diseaseMulticenter studyCarcinoma Basal CellCase-Control Studies030220 oncology & carcinogenesisFemalebusiness

description

The aim of this study was to investigate the role of occupational and nonoccupational ultraviolet (UV)-exposure concerning the development of basal cell carcinoma (BCC).We undertook a population-based multicenter case-control study. Patients with first incident BCC (n = 836) were propensity score matched by age and sex to controls without skin cancer (n = 836). Sociodemographic characteristics, clinical characteristics, and lifetime UV-exposure were assessed by trained investigators. The differential estimation of occupational and nonoccupational UV-exposure dosages was based on validated instruments and established reference values. Associations were assessed using multivariable-adjusted conditional logistic regression models.Individuals with high levels of occupational UV-exposure were at significantly increased BCC-risk compared with individuals with low [odds ratio (OR) 1.84; 95% confidence interval (95% CI) 1.19 to 2.83 and moderate (OR 1.97; 95% CI 1.20 to 3.22) occupational UV-exposure. Nonoccupational UV-exposure was not independently associated with BCC.Skin cancer prevention strategies should be expanded to the occupational setting.

yearjournalcountryeditionlanguage
2017-11-08Journal of Occupational & Environmental Medicine
https://doi.org/10.1097/jom.0000000000001217