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RESEARCH PRODUCT

Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure

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AIM:Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and Gal-3; however, the biological and clinical relevance of this interaction is still uncertain. We sought to evaluate, in patients admitted for acute heart failure, the association between plasma Gal-3 with all-cause mortality and the risk for rehospitalizations among high and low levels of CA125. METHODS AND RESULTS: We included 264 consecutive patients admitted for acute heart failure to the Cardiology Department in a third-level center. Both biomarkers were measured on admission. Negative binomial and Cox regression models were used to evaluate the prognostic effect of the interaction between Gal-3 and CA125 (dichotomized by its median) with hospital readmission and all-cause mortality, respectively. During a median follow-up of 2 years (IQR = 1-2.8), 108 (40.9%) patients deaths and 365 rehospitalizations in 171 (69.5%) patients were registered. In a multivariable setting, the effect of Gal-3 on mortality and rehospitalization was differentially mediated by CA125 (p = 0.007 and p67 U/ml), values across the continuum of Gal-3 showed a positive and almost linear relationship with either the risk of death or rehospitalization. Conversely, when CA125 was below median (≤67 U/ml), Gal-3 lacked any prognostic effect on both endpoints. CONCLUSION: In patients with acute heart failure, Gal-3 was strongly associated with higher risk of long-term mortality and repeated rehospitalizations, but only in those patients exhibiting higher values of CA125. Fil: Nuñez, Julio. Universidad de Valencia; España Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires; ; Argentina Fil: Sandino, Justo. Universidad de Valencia; España Fil: Mainar, Luis. Universidad de Valencia; España Fil: Palau, Patricia. Hospital de La Plana; España Fil: Santas, Enrique. Universidad de Valencia; España Fil: Villanueva, María Pilar. Fil: Nuñez, Eduardo. Universidad de Valencia; España Fil: Bodi, Vicent. Universidad de Valencia; España Fil: Chorro, Francisco. Universidad de Valencia; España Fil: Miñana, Gema. Hospital de Manises; España Fil: Sanchis, Juan. Universidad de Valencia; España