6533b7d6fe1ef96bd126716e
RESEARCH PRODUCT
Antioxidant potential of Himanthalia elongata for protection against ischemia-reperfusion injury in the small bowel
Jose Miguel Lloris-cejalvoDolores Cejalvo-lapeñaMariola Belda-antolíJosé Miguel Lloris-carsíCarolina Padrón-sanzBeatriz Prieto-mouresubject
MaleAntioxidantmedicine.medical_treatmentPharmacologymedicine.disease_causeSensitivity and SpecificityAntioxidantsLipid peroxidationSuperoxide dismutaseRandom Allocation03 medical and health scienceschemistry.chemical_compound0302 clinical medicineIntestine SmallHimanthalia elongatamedicineAnimalsIntestinal MucosaRats Wistarchemistry.chemical_classificationbiologyPlant ExtractsGlutathione peroxidaseBiopsy NeedleSeaweedmedicine.diseasebiology.organism_classificationImmunohistochemistryRatsDisease Models AnimalTreatment OutcomechemistryBiochemistryCatalaseReperfusion Injury030220 oncology & carcinogenesisbiology.protein030211 gastroenterology & hepatologySurgeryLipid PeroxidationReperfusion injuryOxidative stressPhytotherapydescription
Seaweed has been associated with the prevention and/or treatment of various diseases related to oxidative stress because of its antioxidant activity. We investigated the protective potential of extract of Himanthalia elongata against ischemia-reperfusion (I/R) injury in the intestine of rats.Seventy-two (72) male Wistar albino rats were randomly assigned into 12 groups as follows: sham, I/R only, I/R plus vehicle at 3 time points, and I/R plus extract at 3 time points. The degree of intestinal injury was determined by oxidative stress using lipid peroxidation, superoxide dismutase, catalase, and glutathione peroxidase after mesenteric ischemia-reperfusion. A histological study was also performed.The algae extract helps to maintain normal enzymatic levels because, for all the studied parameters, groups treated with the extract showed significant differences (P .05) compared with the I/R groups, and there were no differences compared with the sham group. The histological study showed that damage to the intestinal mucosa was less severe in animals treated with extract of H elongata after up to 24 hours of reperfusion compared with the I/R group.These results suggest that the extract of H elongata can protect intestinal tissue against ischemia-reperfusion injury.
year | journal | country | edition | language |
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2016-11-16 | Surgery |