6533b7d7fe1ef96bd1267a19

RESEARCH PRODUCT

A finite element-based machine learning approach for modeling the mechanical behavior of the breast tissues under compression in real-time

S. Martínez-sanchisMarcelino Martínez-soberJ. A. Solves-llorensAntonio J. Serrano-lópezJosé D. Martín-guerreroF. Martínez-martínezCarlos MonserratD. LorenteMaria J. Ruperez-moreno

subject

AdultFinite element methodsMean squared errorComputer scienceQuantitative Biology::Tissues and OrgansINGENIERIA MECANICAFinite Element AnalysisPhysics::Medical PhysicsDecision treeBreast compressionHealth Informatics02 engineering and technologyMachine learningcomputer.software_genreModels Biological030218 nuclear medicine & medical imagingSet (abstract data type)03 medical and health sciencesImaging Three-Dimensional0302 clinical medicineMachine learning0202 electrical engineering electronic engineering information engineeringHumansBreastbusiness.industryModelingEnsemble learningFinite element methodComputer Science ApplicationsRandom forestEuclidean distanceTree (data structure)Female020201 artificial intelligence & image processingArtificial intelligenceBreast biomechanicsbusinesscomputerLENGUAJES Y SISTEMAS INFORMATICOS

description

[EN] This work presents a data-driven method to simulate, in real-time, the biomechanical behavior of the breast tissues in some image-guided interventions such as biopsies or radiotherapy dose delivery as well as to speed up multimodal registration algorithms. Ten real breasts were used for this work. Their deformation due to the displacement of two compression plates was simulated off-line using the finite element (FE) method. Three machine learning models were trained with the data from those simulations. Then, they were used to predict in real-time the deformation of the breast tissues during the compression. The models were a decision tree and two tree-based ensemble methods (extremely randomized trees and random forest). Two different experimental setups were designed to validate and study the performance of these models under different conditions. The mean 3D Euclidean distance between nodes predicted by the models and those extracted from the FE simulations was calculated to assess the performance of the models in the validation set. The experiments proved that extremely randomized trees performed better than the other two models. The mean error committed by the three models in the prediction of the nodal displacements was under 2 man, a threshold usually set for clinical applications. The time needed for breast compression prediction is sufficiently short to allow its use in real-time (< 0.2 s).

10.1016/j.compbiomed.2017.09.019https://doi.org/10.1016/j.compbiomed.2017.09.019