Intrauterine growth restriction and congenital malformations: a retrospective epidemiological study

6533b7dbfe1ef96bd1270265

RESEARCH PRODUCT

Intrauterine growth restriction and congenital malformations: a retrospective epidemiological study

Giuseppe Puccio Ettore Piro Mario Giuffrè Giovanni Corsello Grazia Rinaudo Maria Piccione

subject

Male Pediatrics medicine.medical_specialty Birth weight Population Intrauterine growth restriction Gestational Age Sensitivity and Specificity Body Mass Index Congenital Abnormalities Settore MED/38 - Pediatria Generale E Specialistica Weight percentile Neonatal Screening Predictive Value of Tests Pregnancy Risk Factors Prevalence Medicine Birth Weight Humans education Sicily reproductive and urinary physiology Retrospective Studies Congenital malformations SGA Pregnancy education.field_of_study Fetal Growth Retardation business.industry Obstetrics Research Infant Newborn Gestational age medicine.disease Body Height female genital diseases and pregnancy complications Ponderal index Predictive value of tests Infant Small for Gestational Age Small for gestational age Congenital malformation Female business Body mass index

description

Background: Intrauterine growth restriction (IUGR) and small for gestational age (SGA) birth have been considered possible indicators of the presence of malformations. The aim of this study is to evaluate such relationships in a population of newborns, along with other epidemiological and auxological parameters, in particular the ponderal index (PI). Methods: We analyzed the birth data of 1093 infants, classified according to weight for gestational age as SGA, appropriate for gestational age (AGA) or large for gestational age (LGA). The prevalence of malformations was analyzed in relation to weight percentile at birth and SGA birth, maternal smoking, pregnancy diseases and PI. Results: Our analysis showed no significant relationship between the prevalence of malformations and SGA birth. Maternal smoking and pregnancy diseases were strongly related to SGA birth, but not to a higher prevalence of malformations. PI, however, had a significant relationship with a higher prevalence of malformations, if analyzed as either a continuous variable or a categorical variable (cutoff: < 2.4). Conclusions: The association between congenital malformations and birth weight for gestational age seems to be weak. As part of diagnostic screening for malformations in the neonatal period, PI could be considered a better predictor of risk than weight percentile.

year	journal	country	edition	language
2013-04-01	Italian Journal of Pediatrics

10.1186/1824-7288-39-23 http://dx.doi.org/10.1186/1824-7288-39-23