6533b7dcfe1ef96bd1272053

RESEARCH PRODUCT

ANTIPROLIFERATIVE ACTIVITY OF CITRUS JUICES AND HPLC EVALUATION OF THEIR FLAVONOID COMPOSITION

Vita Di StefanoSergio Fatta Del BoscoDomenico SchillaciLorenzo Camarda

subject

CitrusFlavonoidHL-60 CellsAntiproliferative activityPharmacognosylaw.inventionchemistry.chemical_compoundlawCell Line TumorDrug DiscoveryHumansPhenolsFood scienceChromatography High Pressure LiquidCell ProliferationPharmacologychemistry.chemical_classificationbiologyGeneral MedicineCitrus speciebiology.organism_classificationAntineoplastic Agents PhytogenicRutaceaechemistryBiochemistryPolyphenolFruitFlavanonesPhytotherapyK562 CellsFlavanoneCitrus × sinensisPhytotherapy

description

The antiproliferative activity of fresh fruit juices extracted from Citrus sinensis (cv. Washington Navel and cv. Sanguinello), C. deliciosa cv. Avana, C. clementina cv. Nules, C. aurantium subsp. myrtifolia , was evaluated against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. All the juices tested showed antiproliferative activity. Moreover, the pattern of the main flavanone compounds in the juices has been determined by HPLC analysis.

yearjournalcountryeditionlanguage
2007-01-01
10.1016/j.fitote.2007.02.020http://hdl.handle.net/10447/10805