Air pollution and childhood leukaemia: a nationwide case-control study in Italy

6533b7defe1ef96bd12766c7

RESEARCH PRODUCT

Air pollution and childhood leukaemia: a nationwide case-control study in Italy

C. Badaloni A. Ranucci G. Cesaroni G. Zanini D. Vienneau F. Al Aidrous K. De Hoogh C. Magnani F. Forastiere C. Magnani Stefano Mattioli L. Miligi A. Ranucci R. Rondelli A. Salvan G. Masera C. Rizzari L. Bisanti P. Zambon A. Greco S. Cannizzaro L. Gafa L. L. Luzzatto A. Benvenuti P. Michelozzi U. Kirchmayer P. Cocco C. Galassi E. Celentano E. Guarino G. Assennato G. De Nichilo D. F. Merlo V. Bocchini P. Mosciatti L. Minelli M. Chiavarini M. Cuttini V. Casotto M. V. Torregrossa R. M. Valenti F. Forastiere R. Haupt S. Lagorio S. Risica A. Polichetti F. Bochicchio C. Nuccetelli P. Biddau M. Arico G. L. De Salvo F. Locatelli Andrea Pession S. Varotto V. Poggi P. Massaglia D. Monetti R. Targhetta G. Bernini F. Pannelli G. Sampietro G. Schiliro A. Pulsoni

subject

Male Pediatrics Air pollution NO2 Land use Regression Model Logistic regression medicine.disease_cause Economica Residence Characteristics USE REGRESSION-MODELS Medicine Child Children Vehicle Emissions General Environmental Science USE REGRESSION-MODELS RESIDENTIAL TRAFFIC DENSITY MAGNETIC-FIELDS POOLED ANALYSIS RISK-FACTOR CANCER EXPOSURE CHILDREN NO2 ASSOCIATION Leukemia Incidence Incidence (epidemiology)ASSOCIATION CANCER Childhood leukaemia Italy Child Preschool Female Case-Control Studie Human medicine.medical_specialty Socio-culturale MAGNETIC-FIELDS POOLED ANALYSIS RISK-FACTOR Air Pollution Occupational Exposure Environmental health Traffic Indicator Humans EXPOSURE RESIDENTIAL TRAFFIC DENSITY Exposure assessment Vehicle Emission business.industry Public Health Environmental and Occupational Health Case-control study Ambientale Infant Carcinogens Environmental Automobile Case-Control Studies Residence Characteristic Dispersion Model Etiology General Earth and Planetary Sciences Particulate Matter Residence business Automobiles

description

Objectives Leukaemia is the most common cancer in children, but its aetiology is still poorly understood. We tested the hypothesis that traffic-related air pollution is associated with paediatric leukaemia because of chronic exposure to several potential carcinogens. Methods The Italian SETIL study (Study on the aetiology of lymphohematopoietic malignancies in children) was conducted in 14 Italian regions. All incident cases of leukaemia in children aged ≤10 years from these regions (period 1998–2001) were eligible for enrolment. Two controls per case, matched on birth date, gender and region of residence were randomly selected from the local population registries. Exposure assessment at birth residence included traffic indicators (distance to main roads and length of main roads within 100 m) and estimates of pollutants concentrations (particulate matter -PM 2.5 and PM 10 - and gases -NO 2 and O 3 -) from national dispersion model and land use regression models. The association between the exposure variables and leukaemia was assessed by logistic regression analyses. Results Participation rates were 91.4% among cases and 69.2% in controls; 620 cases (544 acute lymphocytic and 76 acute non-lymphocytic leukaemia) and 957 controls were included. Overall, when considering the residence at birth, 35.6% of cases and 42.4% of controls lived along busy roads, and the mean annual PM 10 levels were 33.3 (SD=6.3) and 33.4 µg/m 3 (SD=6.5), respectively. No association was found, and all ORs, independent of the method of assessment and the exposure windows, were close to the null value. Conclusions Using various exposure assessment strategies, air pollution appears not to affect the incidence of childhood leukaemia.

year	journal	country	edition	language
2013-01-01	Occupational and Environmental Medicine

https://doi.org/10.1136/oemed-2013-101604