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RESEARCH PRODUCT

CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma

Luiz Paulo KowalskiOslei Paes De AlmeidaPablo Agustin VargasFelipe Paiva FonsecaRaghu RadhakrishnanBruno Augusto Linhares Almeida MarizMárcio Ajudarte LopesMohit SharmaLuan César Da Silva

subject

medicine.medical_specialtyOral Submucous FibrosisGastroenterologyMalignant transformation03 medical and health sciences0302 clinical medicineImmune systemAntigenAntigens CDInternal medicinemedicineCarcinomaHumansLectins C-TypeGeneral DentistryLeukoplakiaRetrospective StudiesMouth neoplasmOral Medicine and Pathologybusiness.industryResearch030206 dentistry:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseEpitheliumstomatognathic diseasesmedicine.anatomical_structureMannose-Binding LectinsOtorhinolaryngologyOral submucous fibrosisUNESCO::CIENCIAS MÉDICASCarcinoma Squamous CellSurgeryMouth NeoplasmsLeukoplakia Oralbusiness

description

Background The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Material and Methods Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. Results A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. Conclusions The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation. Key words:Premalignant lesions, oral submucous fibrosis, oral squamous cell carcinoma, immune response.

yearjournalcountryeditionlanguage
2019-12-01Medicina Oral, Patología Oral y Cirugía Bucal
10.4317/medoral.23177http://europepmc.org/articles/PMC6982989