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RESEARCH PRODUCT
Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans
Alexandra SebastianPascal FriesKlaus LiebOliver TüscherPatrick JungArian MobascherMichael SchaumEdoardo PinzutiMichael Wibralsubject
0301 basic medicineAdultMaleRight inferior frontal gyrusComputer scienceQH301-705.5ScienceBiophysicsPrefrontal Cortexstop signal taskGeneral Biochemistry Genetics and Molecular Biologypre-supplementary motor areastopping03 medical and health sciencesBeta band0302 clinical medicineCognitionInhibitory controlReaction TimeHumansresponse inhibitionBiology (General)Response inhibitionMotor areaGeneral Immunology and MicrobiologyOscillationGeneral NeuroscienceQMotor CortexRMagnetoencephalographyCognitionGeneral MedicineMagnetic Resonance ImagingattentionInhibition Psychological030104 developmental biologyMedicineFemaleBeta RhythmNeuroscience030217 neurology & neurosurgeryPsychomotor PerformanceResearch ArticleNeuroscienceHumandescription
Motor inhibitory control implemented as response inhibition is an essential cognitive function required to dynamically adapt to rapidly changing environments. Despite over a decade of research on the neural mechanisms of response inhibition, it remains unclear, how exactly response inhibition is initiated and implemented. Using a multimodal MEG/fMRI approach in 59 subjects, our results reliably reveal that response inhibition is initiated by the right inferior frontal gyrus (rIFG) as a form of attention-independent top-down control that involves the modulation of beta-band activity. Furthermore, stopping performance was predicted by beta-band power, and beta-band connectivity was directed from rIFG to pre-supplementary motor area (pre-SMA), indicating rIFG’s dominance over pre-SMA. Thus, these results strongly support the hypothesis that rIFG initiates stopping, implemented by beta-band oscillations with potential to open up new ways of spatially localized oscillation-based interventions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-03-23 | eLife |