A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice

6533b821fe1ef96bd127b985

RESEARCH PRODUCT

A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice

Domenico Nuzzo Flavia Mulè Marta Di Carlo Simona Terzo Antonella Amato Francesco Bonina Pasquale Picone Giacoma Galizzi

subject

Male 0301 basic medicine obesity Antioxidant medicine.medical_treatment Anti-Inflammatory Agents Apoptosis medicine.disease_cause Settore BIO/09 - Fisiologia Antioxidants Lipid peroxidation chemistry.chemical_compound 0302 clinical medicine insulin resistance Insulin natural antioxidants Nutrition and Dietetics biology Chemistry neurodegeneration obesity; HFD mice; natural antioxidants; insulin resistance; neurodegeneration Brain food and beverages Neurodegenerative Diseases lipids (amino acids peptides and proteins)Inflammation Mediators medicine.symptom lcsh:Nutrition. Foods and food supply Signal Transduction medicine.medical_specialty lcsh:TX341-641 endocrinology_metabolomics Inflammation Diet High-Fat Neuroprotection Article 03 medical and health sciences Insulin resistance Internal medicine medicine Animals HFD mice Cholesterol Insulin Lipid Metabolism medicine.disease Mice Inbred C57BL Disease Models Animal Oxidative Stress Insulin receptor 030104 developmental biology Endocrinology Dietary Supplements Nerve Degeneration biology.protein Lipid Peroxidation natural antioxidant 030217 neurology & neurosurgery Oxidative stress Food Science

description

Obesity and metabolic disorders can be risk factors for the onset and development of neurodegenerative diseases. The aim of the present study was to investigate the protective effects of a natural dietary supplement (NDS), containing Curcuma longa, silymarin, guggul, chlorogenic acid and inulin, on dysmetabolism and neurodegeneration in the brains of high fat diet (HFD)-fed mice. Decrease in the expression of FACL-4, CerS-1, CerS-4, cholesterol concentration and increase in the insulin receptor expression and insulin signaling activation, were found in brains of NDS-treated HFD brains in comparison with HFD untreated-mice, suggesting that NDS is able to prevent brain lipid accumulation and central insulin resistance. In the brains of NDS-treated HFD mice, the levels of RNS, ROS and lipid peroxidation, the expression of p-ERK, H-Oxy, i-NOS, HSP60, NF-kB, GFAP, IL-1&beta

year	journal	country	edition	language
2018-08-21	Nutrients

https://doi.org/10.3390/nu10091130