6533b822fe1ef96bd127d69b

RESEARCH PRODUCT

Nanostructured medical sutures with antibacterial properties

Eduard ArztJuan P. Fernández-blázquezShahram GhanaatiMike BarbeckJames KirkpatrickLuis García-fernándezLutz FunkR.e. UngerPau TuronAránzazu Del CampoCristina Serrano

subject

NanostructureMaterials scienceBiocompatibilityPolymersSurface PropertiesCost-Benefit AnalysisBiophysicsBiocompatible MaterialsBioengineeringPlasma treatmentNanotechnologyBacterial AdhesionBiomaterialsBiofoulingMiceDrug Delivery SystemsEscherichia coliAnimalsSuturesAnti-Bacterial AgentsNanostructuresOxygenMechanics of MaterialsBiofilmsMicroscopy Electron ScanningCeramics and CompositesFemaleStress MechanicalChickensBiomedical engineering

description

Bacterial repellence in suture materials is a desirable property that can potentially improve the healing process by preventing infection. We describe a method for generating nanostructures at the surface of commercial sutures of different composition, and their potential for preventing biofilm formation. We show how bacteria attachment is altered in the presence of nanosized topographies and identify optimum designs for preventing it without compromising biocompatibility and applicability in terms of nanostructure robustness or tissue friction. These studies open new possibilities for flexible and cost-effective realization of topography-based antibacterial coatings for absorbable biomedical textiles.

yearjournalcountryeditionlanguage
2014-09-19Biomaterials
https://doi.org/10.1016/j.biomaterials.2015.02.039