6533b822fe1ef96bd127d88c
RESEARCH PRODUCT
Mechanisms of nanotoxicity – biomolecule coronas protect pathological fungi against nanoparticle-based eradication
Sven BeckerEckhard ThinesMadita WandreyDana WestmeierShirley K. KnauerRoland H. StauberDominic DocterSvenja SiemerGuo-bin Dingsubject
Antifungal AgentsSurface PropertiesBiomedical EngineeringMedizinNanoparticleNanotechnology02 engineering and technology010501 environmental sciencesToxicologyModels Biological01 natural sciencesDrug Resistance FungalAnimalsHumansEcosystem0105 earth and related environmental scienceschemistry.chemical_classificationMicrobial ViabilityBiomoleculeSpores FungalSilicon Dioxide021001 nanoscience & nanotechnologychemistryNanotoxicologyNanoparticlesNanomedicineAdsorptionBotrytis0210 nano-technologyBiologiedescription
Whereas nanotoxicity is intensely studied in mammalian systems, our knowledge of desired or unwanted nano-based effects for microbes is still limited. Fungal infections are global socio-economic health and agricultural problems, and current chemical antifungals may induce adverse side-effects in humans and ecosystems. Thus, nanoparticles are discussed as potential novel and sustainable antifungals via the desired nanotoxicity but often fail in practical applications. In our study, we found that nanoparticles' toxicity strongly depends on their binding to fungal spores, including the clinically relevant pathogen
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-08-25 |