6533b823fe1ef96bd127f5c1
RESEARCH PRODUCT
Detection and quantification of lung cancer biomarkers by a micro-analytical device using a single metal oxide-based gas sensor
Igor BezverkhyyWeber GuyJean-baptiste SanchezAlain CelzardVanessa FierroGeoffrey GregisJean-pierre BellatFranck Bergersubject
Materials scienceSiliconOxidechemistry.chemical_element02 engineering and technology01 natural sciences[SPI.MAT]Engineering Sciences [physics]/MaterialsMetalchemistry.chemical_compoundMaterials ChemistrymedicineGas detectorElectrical and Electronic Engineering[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/MicroelectronicsLung cancerInstrumentationVolume concentration[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph]Chromatography010401 analytical chemistrytechnology industry and agricultureMetals and Alloys021001 nanoscience & nanotechnologyCondensed Matter Physicsmedicine.disease0104 chemical sciences3. Good healthSurfaces Coatings and FilmsElectronic Optical and Magnetic Materialschemistryvisual_artCarbon dioxidevisual_art.visual_art_medium0210 nano-technologyWater vapordescription
International audience; The analysis of exhaled volatile organic compounds (VOCs) related to lung cancer is a very promising wayin medical diagnosis because it is non-invasive and much less expensive than traditional medical analysisused so far. In that sense, a silicon micro-analytical platform consisting of a micro-preconcentrator cou-pled to a silicon spiral gas chromatographic micro-column was built, and a metal oxide-based gas sensorwas used as a miniaturized gas detector. This micro-fabricated device was successfully tested to selec-tively detect low concentrations of VOCs considered as lung cancer biomarkers, within a few minuteseven in presence of high concentrations of water vapor and carbon dioxide.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-02-01 |