6533b825fe1ef96bd1281c28
RESEARCH PRODUCT
Zur Wirkung von Butazolidin auf Glutamins�ure-dehydrogenase und ?-Ketoglutarat-oxydase
Konrad LangK. H. Bässlersubject
Pharmacologychemistry.chemical_classificationRat liver mitochondriaMetabolitePharmacology toxicologyGeneral MedicineMitochondrionchemistry.chemical_compoundEnzymeBiochemistrychemistryPhenylbutazonemedicineGlutamic dehydrogenaseIncubationmedicine.drugdescription
Glutamic dehydrogenase of rat liver mitochondria is inhibited by phenylbutazone at a final concentration of 2,5 mg-% (0,81 · 10−4 M). However, glutamic dehydrogenase in heart muscle homogenate and the cristalline enzyme from liver are not inhibited by phenylbutazone up to 10 mg-% (3,24 · 10−4 M), but they are inhibited by a metabolite arising during incubation of liver mitochondria with phenylbutazone.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1957-01-01 | Naunyn-Schmiedebergs Archiv f�r Experimentelle Pathologie und Pharmakologie |