Imaging photoplethysmography for clinical assessment of cutaneous microcirculation at two different depths

6533b825fe1ef96bd1281f46

RESEARCH PRODUCT

Imaging photoplethysmography for clinical assessment of cutaneous microcirculation at two different depths

Evelina Urtane Aleksejs Miščuks Liga Ozolina-moll Uldis Rubins Zbignevs Marcinkevics Janis Zaharans

subject

Adult Pathology medicine.medical_specialty Adolescent Biomedical Engineering Liniment Hyperemia Cutaneous microcirculation 02 engineering and technology Administration Cutaneous 01 natural sciences Microcirculation 010309 optics Biomaterials Young Adult Photoplethysmogram 0103 physical sciences Image Processing Computer-Assisted Humans Medicine Photoplethysmography Skin business.industry Microcirculation Equipment Design Laser Doppler velocimetry Hand 021001 nanoscience & nanotechnology Arterial occlusion Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials 0210 nano-technology business Perfusion Preclinical imaging Anesthesia Local Biomedical engineering

description

The feasibility of bispectral imaging photoplethysmography (iPPG) system for clinical assessment of cutaneous microcirculation at two different depths is proposed. The iPPG system has been developed and evaluated for in vivo conditions during various tests: (1) topical application of vasodilatory liniment on the skin, (2) skin local heating, (3) arterial occlusion, and (4) regional anesthesia. The device has been validated by the measurements of a laser Doppler imager (LDI) as a reference. The hardware comprises four bispectral light sources (530 and 810 nm) for uniform illumination of skin, video camera, and the control unit for triggering of the system. The PPG signals were calculated and the changes of perfusion index (PI) were obtained during the tests. The results showed convincing correlations for PI obtained by iPPG530 nm and LDI at (1) topical liniment (r = 0.98) and (2) heating (r = 0.98) tests. The topical liniment and local heating tests revealed good selectivity of the system for superficial microcirculation monitoring. It is confirmed that the iPPG system could be used for assessment of cutaneous perfusion at two different depths, morphologically and functionally different vascular networks, and thus utilized in clinics as a cost-effective alternative to the LDI.

year	journal	country	edition	language
2016-03-30	Journal of Biomedical Optics

https://doi.org/10.1117/1.jbo.21.3.035005