6533b826fe1ef96bd12848bd
RESEARCH PRODUCT
Road Traffic Pollution and Childhood Leukemia: A Nationwide Case-control Study in Italy
Corrado MagnaniAlessandra RanucciChiara BadaloniGiulia CesaroniDaniela FerranteLucia MiligiStefano MattioliRoberto RondelliLuigi BisantiPaola ZambonSantina CannizzaroPaola MichelozziPierluigi CoccoEgidio CelentanoGiorgio AssennatoDomenico Franco MerloPaola MosciattiLiliana MinelliMarina CuttiniMaria Valeria TorregrossaSusanna LagorioRiccardo HauptForastiere FrancescoCorrado MagnaniStefano MattioliAndrea FarioliLucia MiligiAlessandra RanucciDaniela FerranteRoberto RondelliAlberto SalvanGiuseppe MaseraCarmelo RizzariLuigi BisantiPaola ZambonAlessandra Greco VenetoSantina CannizzaroLorenzo GafàLia Lidia LuzzattoAlessandra BenvenutiPaola MichelozziUrsula KirchmayerPierluigi CoccoGalassi ClaudiaEgidio CelentanoErni GuarinoGiorgio AssennatoGigliola De NichiloDomenico Franco MerloVittorio BocchiniPaola MosciattiLiliana MinelliManuela ChiavariniMarina CuttiniVeronica CasottoMaria Valeria TorregrossaRosaria Maria ValentiFrancesco ForastiereRiccardo HauptSusanna LagorioSerena RisicaAlessandro PolichettiFrancesco BochicchioCristina NuccetelliPierfranco BiddauMaurizio AricòGian Luca DesalvoFranco LocatelliAndrea PessionStefania VarottoVincenzo PoggiPia MassagliaDaniele MonettiRoberto TarghettaGabriella BerniniFranco PannelliGiuseppe SampietroGino SchiliròAlessandro PulsoniStefano Parodisubject
MyeloidMaleFuture studies010501 environmental sciencesSettore MED/42 - Igiene Generale E Applicata01 natural sciences0302 clinical medicineEconomicahemic and lymphatic diseasesMedicine030212 general & internal medicineChildRoad trafficacute non lymphoblastic leukemia; childhood; environment; leukemia; road traffic; air pollution; case-control studies; child; child preschool; female; humans; infant; Italy; leukemia myeloid acute; male; precursor cell lymphoblastic leukemia-lymphoma; risk; motor vehicles; medicine (all)LeukemiaTraffic pollutionMedicine (all)General MedicinePrecursor Cell Lymphoblastic Leukemia-LymphomaLeukemiaMotor VehiclesLeukemia Myeloid AcuteItalyAcute non Lymphoblastic LeukemiaSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICARoad TrafficChild PreschoolFemaleMedical emergencyCase-Control StudieHumanRiskChildhood leukemiaSocio-culturaleAcuteEnvironmentPrecursor Cell Lymphoblastic Leukemia Lymphoma03 medical and health sciencesEnvironmental healthAir PollutionHumansPreschool0105 earth and related environmental sciencesbusiness.industryCase-control studyType specificAmbientaleInfantmedicine.diseaseChildhoodCase-Control StudiesMotor Vehiclebusinessdescription
Background The association of childhood leukemia with traffic pollution was considered in a number of studies from 1989 onwards, with results not entirely consistent and little information regarding subtypes. Aim of the study We used the data of the Italian SETIL case-control on childhood leukemia to explore the risk by leukemia subtypes associated to exposure to vehicular traffic. Methods We included in the analyses 648 cases of childhood leukemia (565 Acute lymphoblastic–ALL and 80 Acute non lymphoblastic-AnLL) and 980 controls. Information on traffic exposure was collected from questionnaire interviews and from the geocoding of house addresses, for all periods of life of the children. Results We observed an increase in risk for AnLL, and at a lower extent for ALL, with indicators of exposure to traffic pollutants. In particular, the risk was associated to the report of closeness of the house to traffic lights and to the passage of trucks (OR: 1.76; 95% CI 1.03–3.01 for ALL and 6.35; 95% CI 2.59–15.6 for AnLL). The association was shown also in the analyses limited to AML and in the stratified analyses and in respect to the house in different period of life. Conclusions Results from the SETIL study provide some support to the association of traffic related exposure and risk for AnLL, but at a lesser extent for ALL. Our conclusion highlights the need for leukemia type specific analyses in future studies. Results support the need of controlling exposure from traffic pollution, even if knowledge is not complete.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |