International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein

6533b829fe1ef96bd1289857

RESEARCH PRODUCT

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors

Thue W. Schwartz Uwe Wolfrum Xianhua Piao Robert Fredriksson Yuri A. Ushkaryov Jörg Hamann Simone Prömel Hsi-hsien Lin Torsten Schöneberg Helgi B. Schiöth Ines Liebscher Felix B. Engel Gabriela Aust Kathleen Singer Tobias Langenhan Miriam C. Peeters Barbara Knapp Arunkumar Krishnan Martin Stacey Caroline J. Formstone David C. Martinelli Mario Vallon Breanne L. Harty Kelly Monk Randy A. Hall Demet Araç Mathew W. Wright Christiane Kirchhoff Lei Xu

subject

Models Molecular Societies Scientific Subfamily Computational biology Biology GPR110 Pharmacology Ligands GPR113 Second Messenger Systems Receptors G-Protein-Coupled Cell Movement Terminology as Topic Cell Adhesion Cyclic AMP Animals Humans Protein Isoforms Receptor Nomenclature G protein-coupled receptor Pharmacology Cell Membrane International Agencies Adhesion QP GPR56 Pharmacology Clinical IUPHAR Nomenclature Reports Molecular Medicine QP517 Cell Adhesion Molecules Signal Transduction

description

The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

year	journal	country	edition	language
2015-01-01	Pharmacological Reviews

https://doi.org/10.1124/pr.114.009647