6533b82efe1ef96bd1293247
RESEARCH PRODUCT
Double stimuli-responsive polysaccharide block copolymers as green macrosurfactants for near-infrared photodynamic therapy
Peter WichPeter WichMatthias KonhäuserSapun H. ParekhSapun H. ParekhBenjamin B. BreitenbachYujen WangLea-marie VogtElena Steiertsubject
Indolesmedicine.medical_treatmentBiological Availabilitychemistry.chemical_elementNanoparticlePhotodynamic therapy02 engineering and technologyZincIsoindoles010402 general chemistryPhotochemistry01 natural sciencesMicelleSurface-Active Agentschemistry.chemical_compoundPolysaccharidesAmphiphileOrganometallic CompoundsmedicineCopolymerHumansPhotosensitizerMicellesPhotosensitizing AgentsChemistryDextransGeneral Chemistry021001 nanoscience & nanotechnologyCondensed Matter Physics0104 chemical sciencesPhotochemotherapyZinc CompoundsPhthalocyanineNanoparticles0210 nano-technologyHeLa Cellsdescription
The NIR absorbing photosensitizer phthalocyanine zinc (PC(Zn)) was stabilized in aqueous media as water-dispersible nanoparticles with a reduction- and pH-responsive full polysaccharide block copolymer. A cellular uptake and also photo switchable intracellular activity of the cargo upon irradiation at wavelengths in the near infrared region were shown. The block copolymer was synthesized by applying a copper-free click strategy based on a thiol exchange reaction, creating an amphiphilic double-stimuli-responsive mixed disulfide. The dual-sensitive polysaccharide micelles represent a non-toxic and biodegradable green macrosurfactant for the delivery of phthalocyanine zinc. By encapsulation into micellar nanoparticles, the bioavailability of PC(Zn) increased significantly, enabling smart photodynamic therapy for future applications in cancer-related diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-22 | Soft Matter |