6533b82ffe1ef96bd12948e6

RESEARCH PRODUCT

Measurements of alveolar pO2 using 19F-MRI in partial liquid ventilation.

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Rationale and Objectives: Partial liquid ventilation using Perfluorcarbon (PFC) is an innovative treatment of acute respiratory distress syndrome. However, the underlying mechanisms are not totally clear. The aim was to investigate the distribution of oxygen partial pressure within the PFC-filled lung (ppO 2 ). Methods: Nine pigs underwent partial liquid ventilation, receiving 20 mL PFC/kg bodyweight (bw). Measurements were obtained by a chemical shift selective TurboFLASH sequence at different axial lung levels. ppO 2 was calculated from 1 9 F-MRI by nonlinear curve T 1 -fitting technique after noise correction. Results: Quantification and distribution of ppO 2 was performed successfully. A narrow relationship of the inspiratory O 2 fraction and ppO 2 , as well as a significant ventral-to-dorsal gradient of ppO 2 (ventral:dependent lung = 1.9:1) were detected in all subjects and slice positions. Conclusions: In vivo measurement of local ppO 2 gains new and clinical important insights into the physiology of PLV. The previously unknown ppO 2 gradient within PFC fits to distribution of perfusion. Dependent lung regions appear to have limited access to O 2 from central airways.