Successful treatment of a patient with ARDS after pneumonectomy using high-frequency oscillatory ventilation.

1999

High frequency oscillatory ventilation (HFOV) was used in a patient who developed the acute respiratory distress syndrome 5 days following a right pneumonectomy for bronchogenic carcinoma. When conventional pressure-controlled ventilation failed to maintain adequate oxygenation, HFOV dramatically improved oxygenation within the first few hours of therapy. Pulmonary function and gas exchange recovered during a 10-day period of HFOV. No negative side effects were observed. Early use of HFOV may be a beneficial ventilation strategy for adults with acute pulmonary failure, even in the postoperative period after lung resection.

Bilobectomy for massive hemoptysis after bilateral lung transplantation

2001

AbstractJ Thorac Cardiovasc Surg 2001;121:1194-5

Quantification of Regional Intrapulmonary Oxygen Partial Pressure Evolution during Apnea by 3He MRI

1999

We present a new method to determine in vivo the temporal evolution of intrapulmonary oxygen concentrations by functional lung imaging with hyperpolarized (3)Helium ((3)He-->). Single-breath, single-bolus visualization of (3)He--> administered to the airspaces is used to analyze nuclear spin relaxation caused by the local oxygen partial pressure p(O(2))(t). We model the dynamics of hyperpolarization in the lung by rate equations. Based hereupon, a double acquisition technique is presented to separate depolarization by RF pulses and oxygen induced relaxation. It permits the determination of p(O(2)) with a high accuracy of up to 3% with simultaneous flip angle calibration using no additional …

19F-MRT der Lungenventilation in Atemanhaltetechnik mittels SF6-Gas

2000

Breathhold 19 F-Magnetic Resonance Imaging of Lung Ventilation using SF 6 Gas. Objective: Development of a method to analyze lung ventilation by 19 F-magnetic resonance imaging (MRI) of inspired SF 6 gas during breathhold. Material and Methods: Measurements were performed with a Siemens Magnetom Vision 1.5T scanner using the conventional gradient overdrive. Coronal images of the lung were acquired using ultrafast gradient-echo pulse sequences with TR/TE/α = 1.4 ms/ 0.48 ms/40° without slice selection. With NEX = 200 averages and MA = 32 × 64 raw data matrix, the acquisition time was 9s/image. Higher spatial resolution of 4.7 × 6.3 × 15 mm 3 was obtained with a three-dimensional pulse sequen…

Ein Auswerteprogramm zur quantitativen Untersuchung der Lungenventilation mittels dynamischer MRT von hochpolarisiertem 3He

2004

Purpose: 3 He-MRI is able to visualize the regional distribution of lung ventilation with a temporal and spatial resolution so far unmatched by any other technique. The aim of the study was the development of a new software tool for quantification of dynamic ventilation parameters in absolute physical units. Materials and Methods: During continuous breathing, a bolus of hyperpolarized 3 He (300 ml) was applied at inspiration and a series of 168 coronal projection images simultaneously acquired using a 2D FLASH-sequence. Postprocessing software was developed to analyze the 3 He distribution in the lung. After correction for lung motion, several ventilation parameters (rise time, delay time, …

Lung density distribution in dynamic CT correlates with oxygenation during pressure-controlled ventilation of pigs with lavage-ARDS

2000

The Laryngeal Mask Airway: routine, risk, or rescue?

1999

Software zur automatischen Quantifizierung von Belüftungszuständen bei akutem Lungenversagen in dynamischen CT-Aufnahmen der Lunge1

2001

Purpose: Density measurements in dynamic CT image series of the lungs allow one to quantify ventilated, hyperinflated, and atelectatic pulmonary compartments with high temporal resolution. Fast automatic segmentation of lung parenchyma and a subsequent evaluation of it's respective density values are a prerequisite for any clinical application of this technique. Material and Methods: For automatic lung segmentation in thoracic CT scans, an algorithm was developed which uses (a) different density masks, and (b) anatomic knowledge to differentiate heart, diaphragm and chest wall from ventilated and atelectatic lung parenchyma. With Animal Care Committee approval, the automated technique was t…

3He-MRI-based measurements of intrapulmonarypO2 and its time course during apnea in healthy volunteers: first results, reproducibility, and technical…

2000

We applied a recently developed method of following the time course of the intrapulmonary oxygen partial pressure p(O2)(t) during apnea by (3)He MRI to healthy volunteers. Using two imaging series with different interscan times during two breathholds (double acquisition technique), relaxation of (3)He due to paramagnetic oxygen and depolarization by RF pulses were discriminated. In all four subjects, the temporal evolution of p(O2) was found to be linear, and was described by an initial partial pressure p(0) and a decrease rate R. Also, regional differences of both p(0) and R were observed. A correlation between p(0) and R was apparent. Finally, we discuss limitations of the double acquisit…

3 He-MRI-based vs. conventional determination of lung volumes in patients after unilateral lung transplantation: a new approach to regional spirometry

2002

Background: To use 3Helium (3He)-MRI in patients with unilateral lung grafts to assess the contributions of graft and native lung to total ventilated lung volume, and second to compare conventional measurements of intrapulmonary gas volume (spirometry, body plethysmography) with image-based volumetry of ventilated lung parenchyma visualized by hyperpolarized 3He-MRI. Methods: With Ethics Committee approval, five patients with single lung transplantation (SLTX) for idiopathic pulmonary fibrosis (IPF) underwent both conventional pulmonary function testing (PFT) and 3He-MRI of the lung. Intrapulmonary gas volume (GV) during the inspiratory breathhold for 3He-MRI was calculated from measured fu…

Ventilation Distribution In Two Different Models Of Acute Lung Injury - Electrical Impedance Tomography Validation By Dynamic Xenon-Multidetector-Row…

2011

An�sthesie zur endovaskul�ren Therapie aortaler Aneurysmen Verfahren und perioperative Risiken

1996

Die transvaskulare Plazierung endoluminaler Gefasprothesen mittels interventionell-radiologischer Methoden ist ein neues, minimal invasives Verfahren zur Therapie von Aortenaneurysmen. Wir analysierten retrospektiv die Praktikabilitat verschiedener Anasthesieverfahren, die pathophysiologischen Auswirkungen des Eingriffs und typische Risiken. Bei 19 Patienten mit Aneurysmen der infrarenalen (n=18) oder der thorakalen Aorta (n=1) wurden in 23 Eingriffen aortale Stentprothesen implantiert. Die Eingriffe erfolgten in Allgemeinanasthesie (AA: n=9), in Periduralanasthesie (PDA: n=8) oder Lokalanasthesie (LA: n=6) mit Analgosedierung. Trotz erhohten Uberwachungsaufwands in der Gruppe AA ergaben si…

SPLIT-LUNG VOLUMETRY IN PATIENTS AFTER SINGLE-LUNG TRANSPLANTATION USING 3HELIUM-MRI 

2000

Beeinflussung der Pharmakodynamik von Rocuronium durch Cimetidin

1996

Nach Gabe von Cimetidin kann die Wirkungszeit nichtdepolarisierender Muskelrelaxanzien verlangert sein. Wir untersuchten diesen Zusammenhang fur Rocuronium nach einer Einzeldosis von 400 mg Cimetidin intravenos im Vergleich mit einer Kontrollgruppe. Die Antwort des M. adductor pollicis nach Stimulation des N. ulnaris wurde elektromyographisch registriert. Die Anschlags- und Erholungszeiten sind in beiden Gruppen vergleichbar. Der fehlende Einflus von Cimetidin auf die neuromuskulare Blockade von Rocuronium konnte darauf hindeuten, das die Elimination von Rocuronium nicht nur in der Leber stattfindet. Eine mogliche direkte Beeinflussung der neuromuskularen Endplatte durch Cimetidin, wie sie …

Analysis of discrete and continuous distributions of ventilatory time constants from dynamic computed tomography.

2005

In this study, an algorithm was developed to measure the distribution of pulmonary time constants (TCs) from dynamic computed tomography (CT) data sets during a sudden airway pressure step up. Simulations with synthetic data were performed to test the methodology as well as the influence of experimental noise. Furthermore the algorithm was applied to in vivo data. In five pigs sudden changes in airway pressure were imposed during dynamic CT acquisition in healthy lungs and in a saline lavage ARDS model. The fractional gas content in the imaged slice (FGC) was calculated by density measurements for each CT image. Temporal variations of the FGC were analysed assuming a model with a continuous…

Flip angle considerations in (3)helium-MRI.

2000

3Helium-MRI ((3)He-MRI) can be used for analysis of lung function, e. g. dynamic imaging of ventilation and gas diffusion within the lung, assessment of intrapulmonary oxygen concentrations and their time course. During imaging, the irreversible signal loss due to depolarizing radio frequency excitations can be described using the flip angle (FA) alpha. This parameter has to be quantified in order to account for it during quantitative assessment of the (3)helium signal intensity and its temporal development. This technical report reviews two different methods to determine alpha. Limitations and possible error sources of each method are discussed.

Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS

2021

Background Sigh is a cyclic brief recruitment maneuver: previous physiologic studies showed that its use could be an interesting addition to pressure support ventilation to improve lung elastance, decrease regional heterogeneity, and increase release of surfactant. Research Question Is the clinical application of sigh during pressure support ventilation (PSV) feasible? Study Design and Methods We conducted a multicenter noninferiority randomized clinical trial on adult intubated patients with acute hypoxemic respiratory failure or ARDS undergoing PSV. Patients were randomized to the no-sigh group and treated by PSV alone, or to the sigh group, treated by PSV plus sigh (increase in airway pr…

Heterogeneity Of Lung Ventilation In COPD Patients And Healthy Adults Determined By Electrical Impedance Tomography

2011

Respiratory mechanics measured by forced oscillations during mechanical ventilation through a tracheal tube

2011

The forced oscillation technique (FOT) allows the measurement of respiratory mechanics in the intensive care setting. The aim of this study was to compare the FOT with a reference method during mechanical ventilation through a tracheal tube. The respiratory impedance spectra were measured by FOT in nine anaesthetized pigs, and resistance and compliance were estimated on the basis of a linear resistance-compliance inertance model. In comparison, resistance and compliance were quantified by the multiple linear regression analysis (LSF) of conventional ventilator waveforms to the equation of motion. The resistance of the sample was found to range from 6 to 21 cmH(2)O s l(-1) and the compliance…

Combined Epidural and General Anesthesia Prevents Excessive Oxygen Consumption Postoperatively

1994

In the postoperative period patients are at risk of excessive oxygen consumption (VO2). However, patients suffering from cardiovascular disease may be unable to increase their oxygen transport capacity sufficiently and may be especially vulnerable to tissue hypoxia as part of the reaction to intraoperative stress. During the last 10 years contradictory results concerning the benefits of a combined epidural and light general anesthesia have been published. Some of the results indicate that postoperative catabolism maybe depressed and that the neuroendocrine response to stress may be inhibited by such a combined technique1,2. We studied the effect of a combined epidural and light general anes…

Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Ge…

2021

Summary Background Previous studies indicate that isoflurane could be useful for the sedation of patients in the intensive care unit (ICU), but prospective studies evaluating isoflurane's efficacy have been small. The aim of this study was to test whether the sedation with isoflurane was non-inferior to sedation with propofol. Methods This phase 3, randomised, controlled, open-label non-inferiority trial evaluated the efficacy and safety of up to 54 h of isoflurane compared with propofol in adults (aged ≥18 years) who were invasively ventilated in ICUs in Germany (21 sites) and Slovenia (three sites). Patients were randomly assigned (1:1) to isoflurane inhalation via the Sedaconda anaesthet…

Measurements of alveolar pO2 using 19F-MRI in partial liquid ventilation.

2003

Rationale and Objectives: Partial liquid ventilation using Perfluorcarbon (PFC) is an innovative treatment of acute respiratory distress syndrome. However, the underlying mechanisms are not totally clear. The aim was to investigate the distribution of oxygen partial pressure within the PFC-filled lung (ppO 2 ). Methods: Nine pigs underwent partial liquid ventilation, receiving 20 mL PFC/kg bodyweight (bw). Measurements were obtained by a chemical shift selective TurboFLASH sequence at different axial lung levels. ppO 2 was calculated from 1 9 F-MRI by nonlinear curve T 1 -fitting technique after noise correction. Results: Quantification and distribution of ppO 2 was performed successfully. …

Comparison of magnetic resonance imaging of inhaled SF6 with respiratory gas analysis

2008

Magnetic resonance imaging of inhaled fluorinated inert gases ((19)F-MRI) such as sulfur hexafluoride (SF(6)) allows for analysis of ventilated air spaces. In this study, the possibility of using this technique to image lung function was assessed. For this, (19)F-MRI of inhaled SF(6) was compared with respiratory gas analysis, which is a global but reliable measure of alveolar gas fraction. Five anesthetized pigs underwent multiple-breath wash-in procedures with a gas mixture of 70% SF(6) and 30% oxygen. Two-dimensional (19)F-MRI and end-expiratory gas fraction analysis were performed after 4 to 24 inhaled breaths. Signal intensity of (19)F-MRI and end-expiratory SF(6) fraction were evaluat…

Temporal dynamics of lung aeration determined by dynamic CT in a porcine model of ARDS

2001

We used dynamic CT to identify two different time constants of lung aeration and their individual contribution to the total increase in cross-sectional lung area in healthy and experimentally damaged lungs. In five healthy pigs, inflation and deflation between 0 and 50 cm H2O was imposed during dynamic (250 ms/image) CT acquisition, and repeated after experimental lung injury by saline lavage. The fractional areas of density ranges, which represent aerated lung parenchyma, were determined planimetrically, and their time for expansion during the manoeuvre was fitted using a bi-exponential model. Thus, two compartments, their sizes, i.e. their relative contributions to lung area aerated by th…

Ultraschnelle MRT der Lungenventilation mittels hochpolarisiertem Helium-3*

2000

Objective Assessment of the temporal and spatial dynamics of hyperpolarized Helium-3 (3He) distribution in the lung with ultrafast gradient-echo magnetic-resonance imaging. Material and methods Coronal images of the lung were acquired using ultrafast gradient-echo pulse sequences with TR/TE = 3.3 ms/1.3 ms (slice thickness, 40 mm) and TR/TE = 2.0 ms/0.7 ms (without slice selection). A series of 80 or 160 projection images was obtained with 210 ms or 130 ms temporal resolution, respectively. Imaging was performed during several respiratory cycles after application of a single bolus of 300 mL hyperpolarized 3He. Measurements were performed in six healthy volunteers (spontaneous breathing). Re…

Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the translati…

2017

Electrical impedance tomography (EIT) has undergone 30 years of development. Functional chest examinations with this technology are considered clinically relevant, especially for monitoring regional lung ventilation in mechanically ventilated patients and for regional pulmonary function testing in patients with chronic lung diseases. As EIT becomes an established medical technology, it requires consensus examination, nomenclature, data analysis and interpretation schemes. Such consensus is needed to compare, understand and reproduce study findings from and among different research groups, to enable large clinical trials and, ultimately, routine clinical use. Recommendations of how EIT findi…

Spiral-CT und 3 D-Rekonstruktion des Tracheobronchialbaumes zur Auswahl geeigneter Doppellumentuben vor Einzellungenbeatmung

1997

Purpose To assess the potential of 3-D spiral CT in the selection of adequate double-lumen tubes (DLT) for one-lung-ventilation. Materials and methods 3-D spiral CT of eight different DLTs was performed with standardized acquisition parameters: section thickness 4 mm, table speed 6 mm/s, increment 3 mm and standardised thresholds, window settings and magnification zoom. The accuracy was confirmed by measuring 3-D objects on screen and original DLTs by vernier caliper. 3-D spiral CT was performed in 20 patients preoperatively with slice thickness 4-8 mm, pitch 1-1.5, increment 4-8 mm. To select the adequate DLT size the 3-D reconstructions of the patient's tracheobronchial tree and of the DL…

The AVL-mode: a safe closed loop algorithm for ventilation during total intravenous anesthesia.

1994

The Adaptive Lung Ventilation Controller (ALV-Controller) represents a new approach to closed loop control of ventilation. It is based on a pressure controlled ventilation mode. Adaptive lung ventilation signifies automatic breath by breath adaptation of breathing patterns to the lung mechanics of an individual patient. The specific goals are to minimize work of breathing, to maintain a preset alveolar ventilation and to prevent the occurrence of intrinsic PEEP. We ventilated 5 patients undergoing major abdominal procedures using ALV. ALV was tolerated well in all patients. Alveolar ventilation was preset between 5500 and 6500 ml/min. Serial dead space (Vds) and respiratory time constant (r…

Dynamic computed tomography: a novel technique to study lung aeration and atelectasis formation during experimental CPR

2002

Objective: To develop an image based technique to study the effect of different ventilatory strategies on lung ventilation and alveolar recruitment during cardiopulmonary resuscitation (CPR). Design: (1) Technical development of the following components: (a) construction of an external chest compression device, which does not interfere with CT imaging, and (b) development of a software tool to detect lung parenchyma automatically and to calculate radiological density parameters. (2) Feasibility studies: three strategies of CPR ventilation were performed and imaged in one animal each (pigs, 25 kg): volume-constant ventilation (VCV), no ventilation, or continuous airway pressure (CPAP). One m…

Laryngeal Mask Airway Position and the Risk of Gastric Insufflation

1998

A potential risk of the laryngeal mask airway (LMA) is an incomplete mask seal causing gastric insufflation or oropharyngeal air leakage.The objective of the present study was to assess the incidence of LMA malpositions by fiberoptic laryngoscopy, and to determine their influence on gastric insufflation and oropharyngeal air leakage. One hundred eight patients were studied after the induction of anesthesia, before any surgical manipulations. After clinically satisfactory LMA placement, tidal volumes were increased stepwise until air entered the stomach, airway pressure exceeded 40 cm H2 O, or air leakage from the mask seal prevented further increases in tidal volume. LMA position in relatio…

The Effect Of Automatic Weaning Using Smartcare/ps On Health-Related Quality Of Life

2011

Analysis of the intrapulmonary distribution of ventilation and PO2 in patients after single-lung transplantation: a 3Helium MRI study

2000

Adaptive Lung Ventilation (ALV) Evaluierung eines neuen closed loop-gesteuerten Beatmungsalgorithmus bei Eingriffen in �berstreckter Seitenlage

1996

The lateral decubitus position is the standard position for nephrectomies. There is a lack of data about the effects of this extreme position upon respiratory mechanics and gas exchange. In 20 patients undergoing surgery in the nephrectomy position, we compared a new closed-loop-controlled ventilation algorithm, adaptive lung ventilation (ALV), which adapts the breathing pattern automatically, to the respiratory mechanics with conventionally controlled mandatory ventilation (CMV). The aims of our study were (1) to describe positioning effects on respiratory mechanics and gas exchange, (2) to compare ventilatory parameters selected by the ALV controller with traditional settings of CMV, and …

High-frequency oscillatory ventilation in adults with traumatic brain injury and acute respiratory distress syndrome

2005

This study observed adverse events of rescue treatment with high-frequency oscillatory ventilation (HFOV) in head-injured patients with acute respiratory distress syndrome (ARDS).Data of five male patients with ARDS and traumatic brain injury, median age 28 years, who failed to respond to conventional pressure-controlled ventilation (PCV) were analyzed retrospectively during HFOV. Adjusted mean airway pressure at initiation of HFOV was set to 5 cm H2O above the last measured mean airway pressure during PCV. Frequency of pulmonary air leak, mucus obstruction, tracheal injury, and need of HFOV termination due to increased intracranial pressure, decreased cerebral perfusion pressure, or deteri…

3He MRI in healthy volunteers: preliminary correlation with smoking history and lung volumes

2000

MRI with hyperpolarized helium-3 (3He) provides high-resolution imaging of ventilated airspaces. The first aim of this 3He-study was to compare observations of localized signal defects in healthy smokers and non-smokers. A second aim was to describe relationships between parameters of lung function, volume of inspired 3He and signal-to-noise ratio. With Ethics Committee approval and informed consent, 12 healthy volunteers (seven smokers and five non-smokers) were studied. Imaging was performed in a 1.5 T scanner using a two-dimensional FLASH sequence at 30V transmitter amplitude (TR/TE/α = 11 ms/4.2 ms/<10°). Known amounts of 3He were inhaled from a microprocessor-controlled delivery device…

Multirotations-CT während kontinuierlicher Beatmung: Vergleich unterschiedlicher Dichtebereiche bei gesunden Lungen und im Lavage-ARDS Modell

1999

PURPOSE In this animal study, density ranges for CT-based quantification of ventilated lung area were determined. Healthy lungs and ARDS lungs were compared during artificial respiration. MATERIAL AND METHODS CT-scans were performed in 5 anesthetized pigs using a dynamic multiscan CT option on a predefined transverse slice (slice thickness 1 mm; effective temporal resolution, 250 ms). During continuous CT acquisition, airway pressure was increased or decreased in a stepwise manner. In all images, areas of defined HU ranges were determined planimetrically. The lower threshold was set to -910 HE in all images. The upper threshold was varied from -800 HE to -200 HE in steps of 100 HE. RESULTS …

Analysis of intrapulmonary O2concentration by MR imaging of inhaled hyperpolarized helium-3

1999

Inhalation of hyperpolarized 3He allows magnetic resonance imaging (MRI) of ventilated airspaces.3He hyperpolarization decays more rapidly when interacting with paramagnetic O2. We describe a method for in vivo determination of intrapulmonary O2 concentrations ([O2]) based on MRI analysis of the fate of measured amounts of inhaled hyperpolarized3He in imaged regions of the lung. Anesthetized pigs underwent controlled normoventilation in a 1.5-T MRI unit. The inspired O2 fraction was varied to achieve different end-tidal [O2] fractions ([Formula: see text]). With the use of a specifically designed applicator,3He (100 ml, 35–45% polarized) was administered at a predefined time within single …

Computed tomography-based tracheobronchial image reconstruction allows selection of the individually appropriate double-lumen tube size

1999

Objectives: To determine whether individualized selection of double-lumen tubes or alternatives based on three-dimensional reconstruction of the tracheobronchial image from routine preoperative computed tomography (CT) scans leads to clinically appropriate choices. Design: Prospective observational study; comparison to historic controls. Setting: Anesthesia and radiology facilities of a university medical center. Participants: Forty-nine patients undergoing thoracic surgery requiring one-lung ventilation. Interventions: Three-dimensional image reconstruction of individual tracheobronchial anatomy was performed from routine preoperative spiral CT scans as well as from scans of five left-side…

High-Frequency Oscillatory Ventilation In Patients With Chronic Obstructive Pulmonary Disease

2011

Dynamic19F-MRI of pulmonary ventilation using sulfur hexafluoride (SF6) gas

2001

A new method for dynamic imaging of pulmonary wash-in and wash-out kinetics of inhaled sulfur hexafluoride (SF6) gas was developed. Measurements at the fluorine-19 Larmor frequency were performed in pigs using a gradient echo pulse sequence with 0.5 ms echo time and a measurement time of 9.1 s per image. Dynamic MRI was performed during wash-in and wash-out of SF6 gas in mechanically ventilated porcine lungs. A postprocessing strategy was developed for quantitative determination of wash-out time constants in the presence of noise. Mean wash-out constants were 4.78 ± 0.48 breaths vs. 4.33 ± 0.76 breaths for left and right lung when ventilation was performed with low tidal volume, and 1.73 ± …

Assessment of Pulmonary Mechanics and Gastric Inflation Pressure During Mask Ventilation

1995

AbstractIntroduction:Mask ventilation is a procedure routinely used in emergency medicine. Potential hazards are inadequate alveolar ventilation and inflation of the stomach with air, leading to subsequent regurgitation and aspiration. The aim of this study was to measure lung function and gastric inflation pressures during mask ventilation.Methods:For this purpose, 31 patients scheduled for routine urological procedures were studied during induction of anesthesia. Lung function was assessed by recording respiratory flow and pressure directly at the face mask. Gastric inflation was observed with a microphone taped to the epigastric area.Results:Gastric inflation occurred in 22 of the 31 pat…

Respiratory Mechanics, Gastric Insufflation Pressure, and Air Leakage of the Laryngeal Mask Airway

1997

A potential risk of the laryngeal mask airway (LMA) is incomplete mask seal, which causes air leakage or insufflation of air into the stomach. The objective of the present study was to assess respiratory mechanics, quantify air leakage, and measure gastric air insufflation in patients ventilated via the LMA. Thirty patients were studied after induction of anesthesia but prior to any surgical manipulations. After the insertion of the LMA, patients were ventilated with increasing tidal volumes until one of the three following end points were reached: 1) gastric air insufflation, 2) airway pressure > 40 cm H2O, or 3) limitation of further increase in tidal volume by air leakage. The following …

19F-MRI of perflubron for measurement of oxygen partial pressure in porcine lungs during partial liquid ventilation

2001

A method for in vivo measurement of oxygen partial pressure (pO2) in porcine lungs during partial liquid ventilation (PLV) with perflubron (PFOB) was developed. A pulse sequence for high-resolution MRI of the distribution of PFOB in the lung after intratracheal administration was developed as well. Moreover, quantitative measurements of longitudinal relaxation time T(1) of (19)F resonances for assessment of regional pO2 are described. Due to the need to acquire data during a single expiratory breathhold, only low SNRs were achieved in vivo. Therefore, simulations were performed to investigate the influence of background noise on T(1) values calculated from data with low SNR. Based on these …

Ventilation-Perfusion Ratio in Perflubron During Partial Liquid Ventilation

2010

BACKGROUND: Functional magnetic resonance imaging (fMRI) of fluorine-19 allows for the mapping of oxygen partial pressure within perfluorocarbons in the alveolar space (Pao(2)). Theoretically, fMRI-detected Pao(2) can be combined with the Fick principle approach, i.e., a mass balance of oxygen uptake by ventilation and delivery by perfusion, to quantify the ventilation-perfusion ratio (Va/Q) of a lung region: The mixed venous blood and the inspiratory oxygen fraction, which are equal for all lung regions, are measured. In addition, the local expiratory oxygen fraction and the end capillary oxygen content, both of which may differ between the lung regions, are calculated using the fMRI-detec…

Lung density distribution in dynamic CT correlates with oxygenation in ventilated pigs with lavage ARDS † †This study contains parts of the doctoral …

2003

Background Fast dynamic computed tomography (dCT) has been used to assess regional dynamics of lung inflation and deflation processes. The aim of this study was to relate ventilation-induced changes in lung density distribution, as measured over several respiratory cycles by dCT, to oxygenation and shunt fraction in a lavage acute respiratory distress syndrome model. Methods Six anaesthetized pigs underwent pressure-constant ventilation (F I O2=1.0, inspiratory:expiratory ratio=1:1) before and after induction of lung damage by saline lavage. Mean airway pressure ( P a μ w μ ) was varied (8, 13, 18, 23, 28, 33, and 38 cm H2O) in random order. At each P a μ w μ level, dCT acquisitions were pe…

Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: Study protocol for a pilot randomized controlled trial, the PROT…

2018

Background Adding cyclic short sustained inflations (sigh) to assisted ventilation yields optimizes lung recruitment, decreases heterogeneity and reduces inspiratory effort in patients with acute hypoxemic respiratory failure (AHRF). These findings suggest that adding sigh to pressure support ventilation (PSV) might decrease the risk of lung injury, shorten weaning and improve clinical outcomes. Thus, we conceived a pilot trial to test the feasibility of adding sigh to PSV (the PROTECTION study). Methods PROTECTION is an international randomized controlled trial that will be conducted in 23 intensive care units (ICUs). Patients with AHRF who have been intubated from 24 h to 7 days and under…